Nimisha Gawde, MBBS
Postdoctoral FellowAbout
Research
Publications
2026
Redefining the contribution of retrograde menstruation to endometriosis: single-cell analysis of endometriotic lesions suggests a process more complex than simple autografting
Mamillapalli R, Pyneni K, Watson K, Habata S, Gawde N, Taylor H. Redefining the contribution of retrograde menstruation to endometriosis: single-cell analysis of endometriotic lesions suggests a process more complex than simple autografting. Molecular Medicine 2026, 32: 41. PMID: 41714950, PMCID: PMC13020223, DOI: 10.1186/s10020-026-01442-3.Peer-Reviewed Original ResearchEndometriotic lesionsPeritoneal implantsPeritoneal cavityNatural killer (NK) cellsGreen fluorescent proteinDevelopment of endometriotic lesionsImplantation of endometriumWild type miceDevelopment of endometriosisSingle cell suspensionsInfiltration of circulating cellsSingle-cell sequencing analysisTransplanted endometriumUterine allograftPelvic painDonor miceRetrograde menstruationT cellsUterine tissueImmune cellsType miceB cellsGynecological disordersEndometriosis cellsSingle-cell analysisSex-specific differences in liver DNA methylation patterns and epigenetic aging in mice
Apelian S, Mamillapalli R, Ucar A, Gawde N, Taylor H. Sex-specific differences in liver DNA methylation patterns and epigenetic aging in mice. AJP Gastrointestinal And Liver Physiology 2026, 330: g361-g367. PMID: 41697067, DOI: 10.1152/ajpgi.00322.2025.Peer-Reviewed Original ResearchConceptsDNA methylation patternsMethylation patternsCpG sitesMethylation ratioCpG lociMethylation differencesSex-specific differencesGenomic DNADNA methylation-based predictorsEpigenetic ageEpigenetic changesDisease susceptibilityDNASexual dimorphismGenesBisulfite-convertedEpigenetic clocksCpGFemale miceBiological ageMethylationYoung miceAged C57BL/6 miceMiceSex differences
2025
MICRORNA TREATMENTS ALLEVIATE ENDOMETRIOSIS INDUCED DEPRESSION
Gawde N, Mamillapalli R, Zhou Y, Gao X, Taylor H. MICRORNA TREATMENTS ALLEVIATE ENDOMETRIOSIS INDUCED DEPRESSION. Fertility And Sterility 2025, 124: e41. DOI: 10.1016/j.fertnstert.2025.07.170.Peer-Reviewed Original ResearchIL-6 Inhibits Invasion in a Murine Model of Endometriosis
Han E, Mamillapalli R, Cevik E, Gawde N, Thomas K, Taylor H. IL-6 Inhibits Invasion in a Murine Model of Endometriosis. Reproductive Sciences 2025, 32: 3557-3566. PMID: 41120690, DOI: 10.1007/s43032-025-01984-7.Peer-Reviewed Original ResearchConceptsSignaling pathwayIL-6 signaling pathwayAnti-IL-6RJAK/STAT signalingMolecular mechanismsIL-6N-cadherinP38 MAPKMurine modelAnti-IL-6 receptor monoclonal antibodyMolecular targetsPathwayAnti-IL-6R antibodyMurine model of endometriosisPresence of endometrial tissueModel of endometriosisPathophysiology of endometriosisC57BL/6 female miceInvasionIsotype control groupReproductive age womenMonoclonal antibodiesNon-invasive therapyMediated pathwayParadoxical roleThe role of long non-coding ribonucleic acid HOXA11-AS in endometriosis therapy
Mamillapalli R, Gawde N, Fay M, Atwani R, Moridi I, Taylor H. The role of long non-coding ribonucleic acid HOXA11-AS in endometriosis therapy. Reproductive Biology And Endocrinology 2025, 23: 83. PMID: 40457415, PMCID: PMC12128536, DOI: 10.1186/s12958-025-01420-0.Peer-Reviewed Original ResearchConceptsHOXA11-ASHOXA11-AS expressionEutopic endometriumLong non-coding RNAsEctopic endometriotic lesionsEndometriotic cell linesInvasion of endometriosisEndometrial stromal cellsReal-time polymerase chain reactionNon-coding RNAsEndometriotic lesionsEndometriosis therapyEndometriosis patientsNormal endometriumProgestin responsivenessEndometrial developmentTreatment responsePolymerase chain reactionQuantitative real-time polymerase chain reactionEndometriosisEndometriosis treatmentMethodsTissue samplesStromal cellsPotential target genesEndometriumImpact of peritoneal macrophage depletion on endometriotic lesion development in a mouse model.
Stratopoulou C, Cacciottola L, Gawde N, Ngombo A, Brusa D, Donnez J, Taylor H, Dolmans M. Impact of peritoneal macrophage depletion on endometriotic lesion development in a mouse model. Journal Of Endometriosis And Uterine Disorders 2025, 10: 100113. DOI: 10.1016/j.jeud.2025.100113.Peer-Reviewed Original ResearchEffect of endometriosis-linked microRNAs on hepatic gene expression
Mamillapalli R, Slutzky R, Mangla A, Gawde N, Taylor H. Effect of endometriosis-linked microRNAs on hepatic gene expression. F&S Science 2025, 6: 221-231. PMID: 39971156, DOI: 10.1016/j.xfss.2025.02.001.Peer-Reviewed Original ResearchMiR-3613-5pMiR-let-7bMiR-125b-5pMiR-150MiR-150-5pCirculating microRNAsMicroRNAsReactionExpression of IGFBP1Quantitative polymerase chain reactionSuppress target genesExpression of MRC1Polymerase chain reactionBinding sitesReal-time quantitative polymerase chain reactionHepatic gene expressionExpression of CYP2R1Bioinformatics analysisEffect of endometriosisSerum of womenCirculation of womenGene expressionChain reactionMiRsHepatic cells
2024
THERAPEUTIC EFFECT OF ENDOMETRIOSIS ASSOCIATED MICRO-RNAS ON HUMAN ENDOMETRIOSIS XENOTRANSPLANTS
Gawde N.R., Mamillapalli R, Taylor H. THERAPEUTIC EFFECT OF ENDOMETRIOSIS ASSOCIATED MICRO-RNAS ON HUMAN ENDOMETRIOSIS XENOTRANSPLANTS. Fertility And Sterility 2024, 122: e156-e157. DOI: 10.1016/j.fertnstert.2024.07.556.Peer-Reviewed Original ResearchIL-6 PREVENTS EXCESSIVE INVASION IN ENDOMETRIOSIS
Mamillapalli R, Han E, Cevik E, Gawde N.R., Thomas K, Taylor H. IL-6 PREVENTS EXCESSIVE INVASION IN ENDOMETRIOSIS. Fertility And Sterility 2024, 122: e157-e158. DOI: 10.1016/j.fertnstert.2024.07.558Peer-Reviewed Original ResearchBone marrow mesenchymal stem cell-derived exosomes shuttle microRNAs to endometrial stromal fibroblasts that promote tissue proliferation /regeneration/ and inhibit differentiation
Bonavina G, Mamillapalli R, Krikun G, Zhou Y, Gawde N, Taylor H. Bone marrow mesenchymal stem cell-derived exosomes shuttle microRNAs to endometrial stromal fibroblasts that promote tissue proliferation /regeneration/ and inhibit differentiation. Stem Cell Research & Therapy 2024, 15: 129. PMID: 38693588, PMCID: PMC11064399, DOI: 10.1186/s13287-024-03716-1.Peer-Reviewed Original ResearchConceptsMiR-100-5pMiR-100MiR-21Transmission electron microscopyMiR-143MiR-143-3pMiR-21-5pEndometrial stromal fibroblastsStromal fibroblastsMicroRNAsExtracellular vesiclesElectron microscopyCell-free regenerative therapyNanoparticle tracking analysisMiRNAsBone marrow mesenchymal stem cell-derived exosomesBone marrow-derived stem cellsMesenchymal stem cell-derived exosomesStem cell-derived exosomesDelivery of microRNAsMarrow-derived stem cellsAssociated with several signaling pathwaysMediators of tissue repairMethodsExtracellular vesiclesUnpaired t-test