Neill Epperson, MD
About
Research
Publications
2024
Traumatic experiences and place of occurrence: An analysis of sex differences among a sample of recently arrived immigrant adults from Latin America
Vargas L, Sammel M, Richmond T, Ulrich C, Giano Z, Berkowitz L, Epperson C. Traumatic experiences and place of occurrence: An analysis of sex differences among a sample of recently arrived immigrant adults from Latin America. PLOS ONE 2024, 19: e0302363. PMID: 38875238, PMCID: PMC11178180, DOI: 10.1371/journal.pone.0302363.Peer-Reviewed Original ResearchConceptsHome countryLatin AmericaU.S. southern borderLatin American migrantsU.S.-Mexico borderCountry of originAmerican migrantsIncreased violenceMigration journeySexual assaultImmigrant adultsEconomic instabilitySexual traumaMigrantsGender differencesExposed to traumatic eventsSouthern borderCountriesAnalysis of sex differencesTraumatic experiencesTrauma exposureLatinTraumatic exposureCombat exposureHomeBeyond the serotonin deficit hypothesis: communicating a neuroplasticity framework of major depressive disorder
Page C, Epperson C, Novick A, Duffy K, Thompson S. Beyond the serotonin deficit hypothesis: communicating a neuroplasticity framework of major depressive disorder. Molecular Psychiatry 2024, 1-12. PMID: 38816586, DOI: 10.1038/s41380-024-02625-2.Peer-Reviewed Original ResearchDepressive disorderTreatment of MDDEmotional brain circuitsMental health crisisMonoaminergic antidepressantsSerotonergic antidepressantsEmotional processingDeficit hypothesisBrain circuitsMDDBehavioral functionsHypothesis explanationAntidepressantsInsufficient supportive evidenceSerotoninNeuromodulation techniquesPreclinical researchNegative biasDisordersPersistent negative biasSupportive evidenceCliniciansPsychotherapyEffective treatmentPsychedelicsSex differences in stress-induced cortisol response among infants of mothers exposed to childhood adversity
Duffy K, Sammel M, Johnson R, Morrison K, Bale T, Epperson C. Sex differences in stress-induced cortisol response among infants of mothers exposed to childhood adversity. Biological Psychiatry 2024 PMID: 38821195, DOI: 10.1016/j.biopsych.2024.05.015.Peer-Reviewed Original ResearchAdverse childhood experiencesMother-infant dyadsCortisol responseSex differencesAssociated with lower cortisol responsesHypothalamic-pituitary-adrenal (HPA) axisStress-induced cortisol responseExposure to childhood abuseSix-month-old infantsAdverse Childhood Experiences QuestionnaireInfants of mothersLow cortisol responseMeasured salivary cortisolSignificant sex differencesImpact of adverse childhood experiencesInfant cortisolChildhood abuseLaboratory stressorHPA axisChildhood adversityMental illnessChildhood experiencesSalivary cortisolAbuseStressorsHarnessing technology to improve sleep in frontline healthcare workers: A pilot study of electronic noise-masking earbuds on subjective and objective sleep measures
Haller H, Moore S, Green K, Johnson R, Sammel M, Epperson C, Novick A. Harnessing technology to improve sleep in frontline healthcare workers: A pilot study of electronic noise-masking earbuds on subjective and objective sleep measures. Science Progress 2024, 107: 00368504241242276. PMID: 38614463, PMCID: PMC11016237, DOI: 10.1177/00368504241242276.Peer-Reviewed Original ResearchConceptsInsomnia Severity IndexHealthcare workersIntervention periodObjective sleep measuresSleep onset latencyBaseline assessmentCompared to baseline assessmentsSleep qualitySleep measuresReported sleep difficultiesPre-post designFrontline healthcare workersPilot studyInsomnia Severity Index scoreSelf-report assessmentsBaseline to interventionNonpharmacological interventionsLinear mixed modelsObjective sleep parametersImprove sleepObjective sleep onset latencySleep difficultiesInterventionSubjective sleep perceptionCompared to baselineApplication of glutamate weighted CEST in brain imaging of nicotine dependent participants in vivo at 7T
Jacobs P, Jee J, Fang L, Devlin E, Iannelli C, Thakuri D, Loughead J, Epperson C, Wilson N, Roalf D, Reddy R, Nanga R. Application of glutamate weighted CEST in brain imaging of nicotine dependent participants in vivo at 7T. PLOS ONE 2024, 19: e0297310. PMID: 38363747, PMCID: PMC10871471, DOI: 10.1371/journal.pone.0297310.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexNon-smokersCingulate gyrusAnterior cingulate cortexContext of addictionTreating nicotine addictionApplication of glutamatePopulation of smokersWilcoxon rank sum testGluCEST imagingTraumatic brain injuryT1-weighted imagesInvestigated glutamateSignificant healthcare issueCingulate cortexGray matter regionsRank sum testNicotine useNicotine addictionNicotine dependenceBrain regionsChemical exchange saturation transferNegative age dependenceHealthy participantsUltra-high field MRIHormones as Psychotropic Interventions in Females
Epperson C. Hormones as Psychotropic Interventions in Females. FOCUS The Journal Of Lifelong Learning In Psychiatry 2024, 22: 63-66. PMID: 38694158, PMCID: PMC11058925, DOI: 10.1176/appi.focus.20230031.Peer-Reviewed Original ResearchReproductive Psychiatry: Postpartum Depression is Only the Tip of the Iceberg
Epperson C, Nagle-Yang S, Novick A. Reproductive Psychiatry: Postpartum Depression is Only the Tip of the Iceberg. FOCUS The Journal Of Lifelong Learning In Psychiatry 2024, 22: 1-2. PMID: 38694150, PMCID: PMC11058918, DOI: 10.1176/appi.focus.20230029.Peer-Reviewed Original ResearchNatural vs. Surgical Postmenopause and Psychological Symptoms Confound the Effect of Menopause on Executive Functioning Domains of Cognitive Experience
Page C, Soreth B, Metcalf C, Johnson R, Duffy K, Sammel M, Loughead J, Epperson C. Natural vs. Surgical Postmenopause and Psychological Symptoms Confound the Effect of Menopause on Executive Functioning Domains of Cognitive Experience. FOCUS The Journal Of Lifelong Learning In Psychiatry 2024, 22: 97-108. PMID: 38694151, PMCID: PMC11058919, DOI: 10.1176/appi.focus.23021034.Peer-Reviewed Original ResearchBrown Attention Deficit Disorder ScaleAttention deficit hyperactivity disorderExecutive dysfunctionSymptom severitySurgical postmenopausePsychological symptomsSelf-reported attention deficit hyperactivity disorderAnxiety symptom severityGeneralized Anxiety Disorder QuestionnaireDepressive symptom severityExecutive function domainsCenter for Epidemiologic Studies Depression ScaleDeficit hyperactivity disorderEpidemiologic Studies Depression ScaleDifficulty sleepingAssociated with difficultiesExecutive functionDisorder ScaleHyperactivity disorderMenopausal transitionGAD-7Sample of womenCES-DCross-sectional sampleAnxiety
2023
GABAergic neuroactive steroid response to sertraline in premenstrual dysphoric disorder
Miller K, Standeven L, Morrow A, Payne J, Epperson C, Hantsoo L. GABAergic neuroactive steroid response to sertraline in premenstrual dysphoric disorder. Psychoneuroendocrinology 2023, 160: 106684. PMID: 38091917, PMCID: PMC10846389, DOI: 10.1016/j.psyneuen.2023.106684.Peer-Reviewed Original ResearchConceptsPremenstrual dysphoric disorderSelective serotonin reuptake inhibitorsGABAergic neuroactive steroidsNeuroactive steroid levelsNeuroactive steroidsSertraline treatmentGABA-A receptorsLuteal phasePregnanolone levelsPMDD groupSerum levelsProgesterone ratioDysphoric disorderSteroid levelsSerotonin reuptake inhibitorsPlacebo-controlled designSubsequent luteal phaseEffect of GABAMenstrual cycle phaseNegative mood symptomsGamma-aminobutyric acidPMDD treatmentSSRI treatmentSSRI sertralineReuptake inhibitors
2002
Psychopharmacology during pregnancy: infant considerations
Walter E, Epperson C. Psychopharmacology during pregnancy: infant considerations. 2002, 642-653. DOI: 10.1093/oso/9780195141733.003.0048.Peer-Reviewed Original ResearchMajor birth defectsHealth care providersNeonatal toxicityDrug exposureMedical recordsBehavioral teratogenicityMental illnessWomen's health care providersBirth defectsPatients' medical recordsNeurobehavioral disturbancesPregnant womenFetal teratogenicityBaseline riskPsychoactive medicationsCare providersGeneral populationMedicationsPregnancyAdverse effectsTeratogenicityFetusesIllnessIncidenceRisk
Links & Media
News
- May 18, 2018
Epperson named Chair of Psychiatry at CU School of Medicine
- October 01, 2006
Grants and contracts awarded to Yale School of Medicine
- June 01, 2006
Grants and contracts awarded to Yale School of Medicine, November/December 2005
- July 01, 2005
Grants and contracts awarded to Yale School of Medicine