Mingming Chen, PhD
Associate Research ScientistAbout
Research
Publications
2025
mGluR4–NPDC1 complex mediates α-synuclein fibril-induced neurodegeneration
Perez-Canamas A, Chen M, Almandoz-Gil L, Khan N, Tang S, Ho A, Gunther E, Strittmatter S. mGluR4–NPDC1 complex mediates α-synuclein fibril-induced neurodegeneration. Nature Communications 2025, 17: 994. PMID: 41444258, PMCID: PMC12848103, DOI: 10.1038/s41467-025-67731-3.Peer-Reviewed Original ResearchThis study investigates how the mGluR4–NPDC1 protein complex mediates neurodegeneration in Parkinson's disease by facilitating α-synuclein fibril uptake, highlighting a potential therapeutic target.
2022
Oridonin ameliorates acetaminophen‐induced acute liver injury through ATF4/PGC‐1α pathway
Yu D, Li J, Wang Y, Guo D, Zhang X, Chen M, Zhou Z. Oridonin ameliorates acetaminophen‐induced acute liver injury through ATF4/PGC‐1α pathway. Drug Development Research 2022, 84: 211-225. PMID: 36567664, DOI: 10.1002/ddr.22024.Peer-Reviewed Original ResearchAstrocyte reactivation in medial prefrontal cortex contributes to obesity-promoted depressive-like behaviors
Yu G, Cao F, Hou T, Cheng Y, Jia B, Yu L, Chen W, Xu Y, Chen M, Wang Y. Astrocyte reactivation in medial prefrontal cortex contributes to obesity-promoted depressive-like behaviors. Journal Of Neuroinflammation 2022, 19: 166. PMID: 35761401, PMCID: PMC9235218, DOI: 10.1186/s12974-022-02529-4.Peer-Reviewed Original Research
2021
Melatonin attenuates repeated mild traumatic brain injury-induced cognitive deficits by inhibiting astrocyte reactivation
Cao R, Li L, Zhang W, Lu J, Wang Y, Chen Q, Zhang W, Chen M, Sheng L, Cai K, Xu G. Melatonin attenuates repeated mild traumatic brain injury-induced cognitive deficits by inhibiting astrocyte reactivation. Biochemical And Biophysical Research Communications 2021, 580: 20-27. PMID: 34607259, DOI: 10.1016/j.bbrc.2021.09.025.Peer-Reviewed Original ResearchBrain circuit dysfunction in specific symptoms of depression
Lv Q, Chen M, Li Y, Yu Y, Liao H. Brain circuit dysfunction in specific symptoms of depression. European Journal Of Neuroscience 2021, 55: 2393-2403. PMID: 33818849, DOI: 10.1111/ejn.15221.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2020
p75NTR Promotes Astrocyte Proliferation in Response to Cortical Stab Wound
Chen M, Guo L, Hao J, Ni J, Lv Q, Xin X, Liao H. p75NTR Promotes Astrocyte Proliferation in Response to Cortical Stab Wound. Cellular And Molecular Neurobiology 2020, 42: 1153-1166. PMID: 33201418, PMCID: PMC11441203, DOI: 10.1007/s10571-020-01006-x.Peer-Reviewed Original ResearchThe CD200/CD200R signaling pathway contributes to spontaneous functional recovery by enhancing synaptic plasticity after stroke
Sun H, He X, Tao X, Hou T, Chen M, He M, Liao H. The CD200/CD200R signaling pathway contributes to spontaneous functional recovery by enhancing synaptic plasticity after stroke. Journal Of Neuroinflammation 2020, 17: 171. PMID: 32473633, PMCID: PMC7260848, DOI: 10.1186/s12974-020-01845-x.Peer-Reviewed Original ResearchHippocampal microglial activation triggers a neurotoxic-specific astrocyte response and mediates etomidate-induced long-term synaptic inhibition
Li D, Chen M, Meng T, Fei J. Hippocampal microglial activation triggers a neurotoxic-specific astrocyte response and mediates etomidate-induced long-term synaptic inhibition. Journal Of Neuroinflammation 2020, 17: 109. PMID: 32264970, PMCID: PMC7140340, DOI: 10.1186/s12974-020-01799-0.Peer-Reviewed Original ResearchNIK links inflammation to hepatic steatosis by suppressing PPARα in alcoholic liver disease
Li Y, Chen M, Zhou Y, Tang C, Zhang W, Zhong Y, Chen Y, Zhou H, Sheng L. NIK links inflammation to hepatic steatosis by suppressing PPARα in alcoholic liver disease. Theranostics 2020, 10: 3579-3593. PMID: 32206109, PMCID: PMC7069072, DOI: 10.7150/thno.40149.Peer-Reviewed Original ResearchAnimalsEthanolFatty AcidsFatty LiverHepatocytesInflammationLiver Diseases, AlcoholicMaleMAP Kinase Kinase 1MAP Kinase Kinase 2MiceMice, Inbred C57BLMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Oxidation-ReductionPhosphorylationPPAR alphaProtein Serine-Threonine KinasesSignal Transduction
2019
Neurogenesis promoted by the CD200/CD200R signaling pathway following treadmill exercise enhances post-stroke functional recovery in rats
Sun H, Li A, Hou T, Tao X, Chen M, Wu C, Chen S, Zhu L, Liao H. Neurogenesis promoted by the CD200/CD200R signaling pathway following treadmill exercise enhances post-stroke functional recovery in rats. Brain Behavior And Immunity 2019, 82: 354-371. PMID: 31513876, DOI: 10.1016/j.bbi.2019.09.005.Peer-Reviewed Original ResearchAnimalsAntigens, CDCell DifferentiationCell ProliferationExercise TestHippocampusInfarction, Middle Cerebral ArteryMaleNeural Stem CellsNeurogenesisNeuronsPhysical Conditioning, AnimalPhysical ExertionRatsRats, Sprague-DawleyReceptors, ImmunologicRecovery of FunctionSignal TransductionStrokeStroke Rehabilitation