Mark Day, PhD
Senior Director, Corporate Development. Alexion PharmaceuticalsAbout
Titles
Senior Director, Corporate Development. Alexion Pharmaceuticals
Biography
I am also a Senior Director in Corporate Development at Alexion Pharmaceuticals focused on ultra rare diseases. Prior to this, I led CNS Business Development at BMS and I was the responsible for the identification & evaluation of the iPierian opportunity (extracellular Tau for PSP). The acquisition was announced on April 31st 2014. I was also responsible for identifying and working with OliPass (a private Korean Biotech focused on PNA-based therapeutics), leading to the announcement of a Worldwide Discovery Alliance with Bristol-Myers Squibb (Oct 2014). My previous appointments included the Head of Translational Imaging and Biochemical Biomarkers (Abbott Labs), Snr Director and Head of Cognitive Neurosciences (Psychogenics), Translational Neuroscience (Wyeth Labs), Principal Investigator (GSK) and I was a Senior Research Fellow (University of Edinburgh) with Richard Morris. I have published over 50 peer-reviewed articles.
Education & Training
- PhD
- Cardiff University (2000)
- BS
- Cardiff University (1997)
Research
Publications
2012
Pharmacological modulation of brain activity in a preclinical model of osteoarthritis
Upadhyay J, Baker SJ, Rajagovindan R, Hart M, Chandran P, Hooker BA, Cassar S, Mikusa JP, Tovcimak A, Wald MJ, Joshi SK, Bannon A, Medema JK, Beaver J, Honore P, Kamath RV, Fox GB, Day M. Pharmacological modulation of brain activity in a preclinical model of osteoarthritis. NeuroImage 2012, 64: 341-355. PMID: 22982372, DOI: 10.1016/j.neuroimage.2012.08.084.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsCentral pharmacological actionsJoint traumaMatrix metalloproteinase inhibitorsMMT animalsFunctional connectivityOsteoarthritis patientsPharmacodynamic effectsPharmacological actionsRecent clinical imaging studiesPharmacological magnetic resonance imagingBrain functionAcute pharmacodynamic effectsBehavioral pain measuresChronic pain patientsFunctional connectivity increasesBroad-spectrum matrix metalloproteinase inhibitorMagnetic resonance imagingClinical imaging studiesFunctional connectivity analysisPain circuitryPain statesPeripheral pathologyFunctional neuroplasticityPain patientsPharmacological therapyXanomeline Modulation of the Blood Oxygenation Level-Dependent Signal in Awake Rats: Development of Pharmacological Magnetic Resonance Imaging as a Translatable Pharmacodynamic Biomarker for Central Activity and Dose Selection
Baker S, Chin CL, Basso AM, Fox GB, Marek GJ, Day M. Xanomeline Modulation of the Blood Oxygenation Level-Dependent Signal in Awake Rats: Development of Pharmacological Magnetic Resonance Imaging as a Translatable Pharmacodynamic Biomarker for Central Activity and Dose Selection. Journal Of Pharmacology And Experimental Therapeutics 2012, 341: 263-273. PMID: 22267203, DOI: 10.1124/jpet.111.188797.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPharmacological magnetic resonance imagingLevel-dependent signalMagnetic resonance imagingDose selectionResonance imagingSingle-photon emission-computed tomographyEffects of xanomelineKetamine-induced activationBlood oxygenation level-dependent (BOLD) signalEarly clinical trialsBlood oxygen level-dependent (BOLD) signalPrimary sensory cortexSensory cortical regionsNovel antipsychotic drugsPositron emission tomographyEmission-computed tomographyBrain activation patternsPhMRI studiesMotor cortexPharmacodynamic biomarkersAntipsychotic drugsClinical trialsAwake ratsSensory cortexAssociation cortex
2010
Awake Rat Pharmacological Magnetic Resonance Imaging as a Translational Pharmacodynamic Biomarker: Metabotropic Glutamate 2/3 Agonist Modulation of Ketamine-Induced Blood Oxygenation Level Dependence Signals
Chin CL, Upadhyay J, Marek GJ, Baker SJ, Zhang M, Mezler M, Fox GB, Day M. Awake Rat Pharmacological Magnetic Resonance Imaging as a Translational Pharmacodynamic Biomarker: Metabotropic Glutamate 2/3 Agonist Modulation of Ketamine-Induced Blood Oxygenation Level Dependence Signals. Journal Of Pharmacology And Experimental Therapeutics 2010, 336: 709-715. PMID: 21172908, DOI: 10.1124/jpet.110.173880.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPharmacological magnetic resonance imagingMagnetic resonance imagingBrain activationPeriaqueductal grayMetabotropic Glutamate 2/3 Receptor AgonistN-methyl-D-aspartate receptor antagonistResonance imagingBOLD signalEarly clinical trialsNegative BOLD signalsNovel experimental therapeuticsPositive BOLD signalRegion-specific mannerPhMRI studiesReceptor antagonistPharmacodynamic biomarkersReceptor agonistSubanesthetic doseAgonist modulationClinical trialsAwake ratsHippocampal regionBasic research findingsDose selectionAnesthetized animalsMidbrain Activation During Pavlovian Conditioning and Delusional Symptoms in Schizophrenia
Romaniuk L, Honey GD, King JR, Whalley HC, McIntosh AM, Levita L, Hughes M, Johnstone EC, Day M, Lawrie SM, Hall J. Midbrain Activation During Pavlovian Conditioning and Delusional Symptoms in Schizophrenia. JAMA Psychiatry 2010, 67: 1246-1254. PMID: 21135324, DOI: 10.1001/archgenpsychiatry.2010.169.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAdultAmygdalaBasal GangliaCase-Control StudiesConditioning, ClassicalCross-Sectional StudiesCuesDelusionsDiagnostic and Statistical Manual of Mental DisordersFemaleHumansMagnetic Resonance ImagingMaleMesencephalonMiddle AgedNeuropsychological TestsPsychotic DisordersSchizophreniaSchizophrenic PsychologySeverity of Illness IndexConceptsHealthy control participantsDelusional symptomsVentral striatumDSM-IV-diagnosed schizophreniaInappropriate activationControl participantsBlood oxygen level-dependent (BOLD) responseAcademic medical centerNegative Syndrome ScaleFunctional magnetic resonance imagingMagnetic resonance imagingRegional brain activationLevel-dependent responsesFunctional magnetic resonanceFunctional neuroimaging studiesPatient groupMedical CenterPavlovian conditioning taskSchizoaffective disorderAbnormal activationSyndrome ScalePatientsResonance imagingMidbrain activationSymptom severityD3 receptor target engagement in humans with ABT-925 using [11C](+)-PHNO PET - a response
Day M, Bain E, Marek G, Saltarelli M, Fox GB. D3 receptor target engagement in humans with ABT-925 using [11C](+)-PHNO PET - a response. The International Journal Of Neuropsychopharmacology 2010, 13: 291-292. PMID: 20196920, DOI: 10.1017/s1461145710000180.Peer-Reviewed Original ResearchCitations
2003
Glutamate-receptor-mediated encoding and retrieval of paired-associate learning
Day M, Langston R, Morris RG. Glutamate-receptor-mediated encoding and retrieval of paired-associate learning. Nature 2003, 424: 205-209. PMID: 12853960, DOI: 10.1038/nature01769.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPaired-associate learningHippocampal neural activityEpisodic memoryHippocampal AMPA receptorsMemory encodingMemory tracesActivity-dependent synapticHippocampal memorySample trialsNeural activityRecallSecond studyMemoryEncodingN-methyl-D-aspartate receptorsIsoxazole propionic acid (AMPA) receptorsLearningPropionic acid receptorsNew pairRetrievalFirst studyAMPA receptorsAnimal modelsAcid receptorsCertain forms