Mario Skarica, MD
Associate Research ScientistCards
About
Research
Publications
2026
Central amygdala single-nucleus atlas reveals chromatin and gene transcription dynamics in human alcohol use disorder
Lee C, Hwang A, McRiley D, Lee J, Thibodeau G, Duman C, Zhang X, Skarica M, Coudriet J, Xu S, Terwilliger R, Sliby A, Wang J, Nguyen T, Liu Y, Li H, Dai Y, Duan Z, Lei Y, Lin Y, Glausier J, Lewis D, Gelernter J, Holtzheimer P, Xu K, Zhou H, Zhao H, Thompson S, Krystal J, Che A, Taylor J, Zhang J, Girgenti M. Central amygdala single-nucleus atlas reveals chromatin and gene transcription dynamics in human alcohol use disorder. Nature Communications 2026, 17: 1634. PMID: 41554730, PMCID: PMC12905162, DOI: 10.1038/s41467-026-68351-1.Peer-Reviewed Original Research
2025
Single-cell transcriptomic and chromatin dynamics of the human brain in PTSD
Hwang A, Skarica M, Xu S, Coudriet J, Lee C, Lin L, Terwilliger R, Sliby A, Wang J, Nguyen T, Li H, Wu M, Dai Y, Duan Z, Srinivasan S, Zhang X, Lin Y, Cruz D, Deans P, Huber B, Levey D, Glausier J, Lewis D, Gelernter J, Holtzheimer P, Friedman M, Gerstein M, Sestan N, Brennand K, Xu K, Zhao H, Krystal J, Young K, Williamson D, Che A, Zhang J, Girgenti M. Single-cell transcriptomic and chromatin dynamics of the human brain in PTSD. Nature 2025, 643: 744-754. PMID: 40533550, PMCID: PMC12267058, DOI: 10.1038/s41586-025-09083-y.Peer-Reviewed Original Research
2024
VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model
Boisserand L, Geraldo L, Bouchart J, Kamouh M, Lee S, Sanganahalli B, Spajer M, Zhang S, Lee S, Parent M, Xue Y, Skarica M, Yin X, Guegan J, Boyé K, Leser F, Jacob L, Poulet M, Li M, Liu X, Velazquez S, Singhabahu R, Robinson M, Askenase M, Osherov A, Sestan N, Zhou J, Alitalo K, Song E, Eichmann A, Sansing L, Benveniste H, Hyder F, Thomas J. VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model. Journal Of Experimental Medicine 2024, 221: e20221983. PMID: 38442272, PMCID: PMC10913814, DOI: 10.1084/jem.20221983.Peer-Reviewed Original Research
2022
AgRP neurons control structure and function of the medial prefrontal cortex
Stutz B, Waterson MJ, Šestan-Peša M, Dietrich MO, Škarica M, Sestan N, Racz B, Magyar A, Sotonyi P, Liu ZW, Gao XB, Matyas F, Stoiljkovic M, Horvath TL. AgRP neurons control structure and function of the medial prefrontal cortex. Molecular Psychiatry 2022, 27: 3951-3960. PMID: 35906488, PMCID: PMC9891653, DOI: 10.1038/s41380-022-01691-8.Peer-Reviewed Original Research
2017
Expression and immunolocalization of metallothioneins MT1, MT2 and MT3 in rat nephron
Sabolić I, Škarica M, Ljubojević M, Breljak D, Herak-Kramberger C, Crljen V, Ljubešić N. Expression and immunolocalization of metallothioneins MT1, MT2 and MT3 in rat nephron. Journal Of Trace Elements In Medicine And Biology 2017, 46: 62-75. PMID: 29413112, DOI: 10.1016/j.jtemb.2017.11.011.Peer-Reviewed Original Research
2013
Immunoregulatory Neuropeptides
Ganea D, Skarica M. Immunoregulatory Neuropeptides. 2013, 144-160. DOI: 10.1002/9781118314814.ch7.Books
2011
Modulation of Inflammatory Responses by a Cannabinoid-2–Selective Agonist after Spinal Cord Injury
Adhikary S, Li H, Heller J, Skarica M, Zhang M, Ganea D, Tuma R. Modulation of Inflammatory Responses by a Cannabinoid-2–Selective Agonist after Spinal Cord Injury. Journal Of Neurotrauma 2011, 28: 2417-2427. PMID: 21970496, PMCID: PMC3235339, DOI: 10.1089/neu.2011.1853.Peer-Reviewed Original ResearchNovel mechanisms of immune modulation of natalizumab in multiple sclerosis patients
Skarica M, Eckstein C, Whartenby K, Calabresi P. Novel mechanisms of immune modulation of natalizumab in multiple sclerosis patients. Journal Of Neuroimmunology 2011, 235: 70-76. PMID: 21550672, DOI: 10.1016/j.jneuroim.2011.02.010.Peer-Reviewed Original Research
2010
Role of metallothionein in cadmium traffic and toxicity in kidneys and other mammalian organs
Sabolić I, Breljak D, Škarica M, Herak-Kramberger C. Role of metallothionein in cadmium traffic and toxicity in kidneys and other mammalian organs. BioMetals 2010, 23: 897-926. PMID: 20549307, DOI: 10.1007/s10534-010-9351-z.Peer-Reviewed Original ResearchDendritic Cells Transduced With Lentiviral Vectors Expressing VIP Differentiate Into VIP-secreting Tolerogenic-like DCs
Toscano M, Delgado M, Kong W, Martin F, Skarica M, Ganea D. Dendritic Cells Transduced With Lentiviral Vectors Expressing VIP Differentiate Into VIP-secreting Tolerogenic-like DCs. Molecular Therapy 2010, 18: 1035-1045. PMID: 20068554, PMCID: PMC2890107, DOI: 10.1038/mt.2009.293.Peer-Reviewed Original ResearchAnimalsBone Marrow CellsCell DifferentiationCell MovementCells, CulturedDendritic CellsEnzyme-Linked Immunosorbent AssayFlow CytometryGenetic VectorsLentivirusMiceMice, Inbred BALB CPolymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionTransduction, GeneticVasoactive Intestinal Peptide