Lei Lei
Associate Research ScientistCards
About
Research
Publications
2026
CFTR gene delivery to human airway epithelia using parainfluenza virus 5 amplifying virus-like particles
Phillips M, Lei L, Kulhankova K, Gingerich M, Loza L, Vu A, He B, Thornell I, McCray P. CFTR gene delivery to human airway epithelia using parainfluenza virus 5 amplifying virus-like particles. Molecular Therapy - Nucleic Acids 2026, 37: 102975. DOI: 10.1016/j.omtn.2026.102975.Peer-Reviewed Original Research
2024
Do pulmonary ionocytes absorb chloride or secrete chloride?
Thornell I, Lei L, McCray P, Welsh M. Do pulmonary ionocytes absorb chloride or secrete chloride? American Journal Of Physiology - Cell Physiology 2024, 328: c400-c403. PMID: 39716827, PMCID: PMC12186486, DOI: 10.1152/ajpcell.00672.2024.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsIl-13 induces loss of CFTR in ionocytes and reduces airway epithelial fluid absorption
Ibarra G, Lei L, Yu W, Thurman A, Gansemer N, Meyerholz D, Pezzulo A, McCray P, Thornell I, Stoltz D. Il-13 induces loss of CFTR in ionocytes and reduces airway epithelial fluid absorption. Journal Of Clinical Investigation 2024, 134: e181995. PMID: 39255033, PMCID: PMC11527443, DOI: 10.1172/jci181995.Peer-Reviewed Original ResearchSystematic optimization of prime editing for the efficient functional correction of CFTR F508del in human airway epithelial cells
Sousa A, Hemez C, Lei L, Traore S, Kulhankova K, Newby G, Doman J, Oye K, Pandey S, Karp P, McCray P, Liu D. Systematic optimization of prime editing for the efficient functional correction of CFTR F508del in human airway epithelial cells. Nature Biomedical Engineering 2024, 9: 7-21. PMID: 38987629, PMCID: PMC11754097, DOI: 10.1038/s41551-024-01233-3.Peer-Reviewed Original ResearchDynamic measurement of airway surface liquid volume with an ex vivo trachea-chip
Scott M, Lei L, Bierstedt K, McCray P, Xie Y. Dynamic measurement of airway surface liquid volume with an ex vivo trachea-chip. Lab On A Chip 2024, 24: 3093-3100. PMID: 38779981, PMCID: PMC11165946, DOI: 10.1039/d4lc00134f.Peer-Reviewed Original Research
2023
CFTR-rich ionocytes mediate chloride absorption across airway epithelia
Lei L, Traore S, Ibarra G, Karp P, Rehman T, Meyerholz D, Zabner J, Stoltz D, Sinn P, Welsh M, McCray P, Thornell I. CFTR-rich ionocytes mediate chloride absorption across airway epithelia. Journal Of Clinical Investigation 2023, 133: e171268. PMID: 37581935, PMCID: PMC10575720, DOI: 10.1172/jci171268.Peer-Reviewed Original Research
2022
Virus-like particles containing a prefusion-stabilized F protein induce a balanced immune response and confer protection against respiratory syncytial virus infection in mice
Luo J, Qin H, Lei L, Lou W, Li R, Pan Z. Virus-like particles containing a prefusion-stabilized F protein induce a balanced immune response and confer protection against respiratory syncytial virus infection in mice. Frontiers In Immunology 2022, 13: 1054005. PMID: 36578490, PMCID: PMC9792133, DOI: 10.3389/fimmu.2022.1054005.Peer-Reviewed Original Research
2021
Chimeric enterovirus 71 virus-like particle displaying conserved coxsackievirus A16 epitopes elicits potent immune responses and protects mice against lethal EV71 and CA16 infection
Luo J, Huo C, Qin H, Hu J, Lei L, Pan Z. Chimeric enterovirus 71 virus-like particle displaying conserved coxsackievirus A16 epitopes elicits potent immune responses and protects mice against lethal EV71 and CA16 infection. Vaccine 2021, 39: 4135-4143. PMID: 34116877, DOI: 10.1016/j.vaccine.2021.05.093.Peer-Reviewed Original ResearchConstruction and immunological evaluation of hepatitis B virus core virus-like particles containing multiple antigenic peptides of respiratory syncytial virus
Lei L, Qin H, Luo J, Tan Y, Yang J, Pan Z. Construction and immunological evaluation of hepatitis B virus core virus-like particles containing multiple antigenic peptides of respiratory syncytial virus. Virus Research 2021, 298: 198410. PMID: 33819519, DOI: 10.1016/j.virusres.2021.198410.Peer-Reviewed Original Research
2020
Y-Box-Binding Protein 3 (YBX3) Restricts Influenza A Virus by Interacting with Viral Ribonucleoprotein Complex and Imparing its Function.
Qin Z, Qu X, Lei L, Xu L, Pan Z. Y-Box-Binding Protein 3 (YBX3) Restricts Influenza A Virus by Interacting with Viral Ribonucleoprotein Complex and Imparing its Function. Journal Of General Virology 2020, 101: 385-398. PMID: 32553055, DOI: 10.1099/jgv.0.001390.Peer-Reviewed Original ResearchA549 CellsAnimalsCCAAT-Enhancer-Binding ProteinsCell NucleusCytoplasmDNA-Directed RNA PolymerasesDogsHeat-Shock ProteinsHEK293 CellsHost Microbial InteractionsHumansInfluenza A virusMadin Darby Canine Kidney CellsMass SpectrometryMiceNuclear ProteinsProtein BindingRibonucleoproteinsRNA, Small InterferingRNA, ViralTranscription, GeneticUp-RegulationViral Core ProteinsVirus Replication
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