Le Zhao
Staff Affiliate - YNHHCards
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Research
Publications
2025
Correction: LincRNA-ROR induces epithelial-to-mesenchymal transition and contributes to breast cancer tumorigenesis and metastasis
Hou P, Zhao Y, Li Z, Yao R, Ma M, Gao Y, Zhao L, Zhang Y, Huang B, Lu J. Correction: LincRNA-ROR induces epithelial-to-mesenchymal transition and contributes to breast cancer tumorigenesis and metastasis. Cell Death & Disease 2025, 16: 340. PMID: 40280900, PMCID: PMC12032008, DOI: 10.1038/s41419-025-07683-0.Peer-Reviewed Original Research
2024
Multi-protomics analysis identified host cellular pathways perturbed by tick-borne encephalitis virus infection
Sui L, Wang W, Guo X, Zhao Y, Tian T, Zhang J, Wang H, Xu Y, Chi H, Xie H, Xu W, Liu N, Zhao L, Song G, Wang Z, Zhang K, Che L, Zhao Y, Wang G, Liu Q. Multi-protomics analysis identified host cellular pathways perturbed by tick-borne encephalitis virus infection. Nature Communications 2024, 15: 10435. PMID: 39616195, PMCID: PMC11608235, DOI: 10.1038/s41467-024-54628-w.Peer-Reviewed Original ResearchConceptsTick-borne encephalitis virusTick-borne encephalitis virus infectionDNA damage responseNon-structural protein NS5Tick-borne flavivirusesHost cellular pathwaysVaccine-breakthrough infectionsDNA damage repairSevere neurological consequencesAbsence of effective vaccinesInnate immune responseRibosome biogenesisEffective antiviral drugsEncephalitis virusTick-transmitted flavivirusImmune responseNeurological consequencesBET degrader exhibits lower antiproliferative activity than its inhibitor via EGR1 recruiting septins to promote E2F1-3 transcription in triple-negative breast cancer
Liu N, Wang S, Li M, Zhao N, Wang D, Zhang R, Yu M, Zhao L, Zhang S, Han F, Zhao Y, Liu Q. BET degrader exhibits lower antiproliferative activity than its inhibitor via EGR1 recruiting septins to promote E2F1-3 transcription in triple-negative breast cancer. Pharmacological Research 2024, 208: 107377. PMID: 39209080, DOI: 10.1016/j.phrs.2024.107377.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic AgentsBromodomain Containing ProteinsCell Cycle ProteinsCell Line, TumorCell ProliferationE2F Transcription FactorsE2F1 Transcription FactorE2F3 Transcription FactorEarly Growth Response Protein 1FemaleGene Expression Regulation, NeoplasticHumansMediator Complex Subunit 1MiceMice, NudeTranscription FactorsTranscription, GeneticTriple Negative Breast NeoplasmsConceptsTriple-negative breast cancerBET proteinsRNA polymerase IIBET bromodomainsInhibiting BET proteinsInhibition of cell growthBET degradersBreast cancerPolymerase IIFamily proteinsCell proliferation rate in vitroIncreased Egr1 expressionProliferation rate in vitroBRD4 depletionLysine residuesSeptinE2F1Cell growthRate in vitroExtraterminal domainAntiproliferative activityBET inhibitionProteinEGR1 expressionCell proliferationClass IIa HDAC4 and HDAC7 cooperatively regulate gene transcription in Th17 cell differentiation
Cheung K, Zhao L, Sharma R, Ghosh A, Appiah M, Sun Y, Jaganathan A, Hu Y, LeJeune A, Xu F, Han X, Wang X, Zhang F, Ren C, Walsh M, Xiong H, Tsankov A, Zhou M. Class IIa HDAC4 and HDAC7 cooperatively regulate gene transcription in Th17 cell differentiation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2312111121. PMID: 38657041, PMCID: PMC11067014, DOI: 10.1073/pnas.2312111121.Peer-Reviewed Original ResearchConceptsClass IIa HDAC4Gene transcriptionCell differentiationTranscriptional activityLineage-specific differentiationHistone deacetylasesTh17 cell differentiationRegulation of gene transcriptionClass II histone deacetylasesCell-specific functionsII histone deacetylasesT cell developmentGenetic methodsNegative regulatorColitis mouse modelTranscriptionMolecular mechanismsSignature genesHDAC7HDAC4GenesIntestinal inflammationNaive CD4+ T cellsCD4+ T cellsT helper 17
2023
BRD4‐PRC2 represses transcription of T‐helper 2‐specific negative regulators during T‐cell differentiation
Zhao L, Wang Y, Jaganathan A, Sun Y, Ma N, Li N, Han X, Sun X, Yi H, Fu S, Han F, Li X, Xiao K, Walsh M, Zeng L, Zhou M, Cheung K. BRD4‐PRC2 represses transcription of T‐helper 2‐specific negative regulators during T‐cell differentiation. The EMBO Journal 2023, 42: embj2022111473. PMID: 36719036, PMCID: PMC10015369, DOI: 10.15252/embj.2022111473.Peer-Reviewed Original ResearchConceptsPolycomb repressive complex 2Cell lineage differentiationTranscriptional repressionPolycomb repressive complex 2 complexHistone H3 lysine 27 trimethylationH3 lysine 27 trimethylationTranscriptional de-repressionTarget gene lociCell type-specific mannerGene transcriptional repressionLysine 27 trimethylationLineage differentiationGene repressionTranscription factor GATA3Gene locusTranscriptional activityTranscriptional programsNegative regulatorLineage-specific differentiationTranscriptional downregulationProtein degradationChemical inhibitionTranscript expressionBrd4's roleBRD4
2022
Polyamines from myeloid-derived suppressor cells promote Th17 polarization and disease progression
Hu C, Zhen Y, Ma Z, Zhao L, Wu H, Shu C, Pang B, Yu J, Xu Y, Zhang X, Wang X, Yi H. Polyamines from myeloid-derived suppressor cells promote Th17 polarization and disease progression. Molecular Therapy 2022, 31: 569-584. PMID: 36307990, PMCID: PMC9931554, DOI: 10.1016/j.ymthe.2022.10.013.Peer-Reviewed Original ResearchConceptsMyeloid-derived suppressor cellsMiR-542-5p expressionMiR-542Th17 differentiationSuppressor cellsTh17 polarizationGroup of immature myeloid cellsMyeloid-derived suppressor cells depletionLevels of Th17 cellsPeripheral blood mononuclear cellsImmature myeloid cellsDisease severityBlood mononuclear cellsTh17 levelsSLE miceTh17 cellsMyeloid cellsMononuclear cellsArginase-1Th17Disease progressionModel miceSLEMolecular pathwaysDisease
2017
BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice
Cheung K, Lu G, Sharma R, Vincek A, Zhang R, Plotnikov A, Zhang F, Zhang Q, Ju Y, Hu Y, Zhao L, Han X, Meslamani J, Xu F, Jaganathan A, Shen T, Zhu H, Rusinova E, Zeng L, Zhou J, Yang J, Peng L, Ohlmeyer M, Walsh M, Zhang D, Xiong H, Zhou M. BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 2952-2957. PMID: 28265070, PMCID: PMC5358349, DOI: 10.1073/pnas.1615601114.Peer-Reviewed Original ResearchConceptsBET proteinsActive RNA polymerase IITh17 cell differentiationProteins regulate gene transcriptionRecruitment of P-TEFbAcetyl-lysine bindingRNA polymerase IICell differentiationInflammatory disordersMature T helper cellsNaive CD4+ T cellsCD4+ T cellsDifferentiation of naive CD4+ T cellsBlocking Th17-cell differentiationEpigenetic drug targetsT-cell transfer-induced colitisBromodomains of BET proteinsPolymerase IITreatment of inflammatory bowel diseaseT helper cellsTranscription elongationT helper 17Housekeeping genesGene locusDifferentiation of Th17
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