Kyle Lyman, MD, PhD
Assistant Professor of NeurologyCards
About
Research
Publications
2025
Angiographic perfusion outperforms large artery vasospasm for predicting the impact of rescue therapy in subarachnoid hemorrhage
Lyman K, Rubin D, Regenhardt R, Webb A, Rordorf G, Edlow B, Kimberly W, Du R, Snider S, Stapleton C, Patel A, Locascio J, Bevers M, Wu O, Chung D. Angiographic perfusion outperforms large artery vasospasm for predicting the impact of rescue therapy in subarachnoid hemorrhage. Journal Of Cerebral Blood Flow And Metabolism : Official Journal Of The International Society Of Cerebral Blood Flow And Metabolism 2025, 45: 2404-2416. PMID: 40719609, PMCID: PMC12303933, DOI: 10.1177/0271678x251361992.Peer-Reviewed Original ResearchImpaired Sphenoparietal Venous Drainage Is Associated With Increased Risk of Vasospasm in Aneurysmal Subarachnoid Hemorrhage
Lyman K, Adusumilli G, Kamdar H, Yang J, Rordorf G, Rubin D, Regenhardt R, Stapleton C, Patel A, Locascio J, Kimberly W, Edlow B, Heit J, Chung D. Impaired Sphenoparietal Venous Drainage Is Associated With Increased Risk of Vasospasm in Aneurysmal Subarachnoid Hemorrhage. Stroke Vascular And Interventional Neurology 2025, 5 DOI: 10.1161/svin.124.001539.Peer-Reviewed Original Research
2024
Characterization of hyperpolarization-activated cyclic nucleotide-gated channels in oligodendrocytes
Lyman K, Han Y, Robinson A, Weinberg S, Fisher D, Heuermann R, Lyman R, Kim D, Ludwig A, Chandel N, Does M, Miller S, Chetkovich D. Characterization of hyperpolarization-activated cyclic nucleotide-gated channels in oligodendrocytes. Frontiers In Cellular Neuroscience 2024, 18: 1321682. PMID: 38469353, PMCID: PMC10925711, DOI: 10.3389/fncel.2024.1321682.Peer-Reviewed Original Research
2023
A Molecular Framework for Delirium
Lyman K. A Molecular Framework for Delirium. The Neurohospitalist 2023, 14: 147-156. PMID: 38666272, PMCID: PMC11040633, DOI: 10.1177/19418744231207925.Peer-Reviewed Original ResearchAttention-deficit/hyperactivity disorderWorking memoryContext of attention-deficit/hyperactivity disorderDorsolateral prefrontal cortexDevelopment of pharmacotherapiesDelirious patientsAlzheimer's diseasePrefrontal cortexCognitive deficitsCognitive domainsPathophysiology of deliriumCognitive changesDLPFCNeural circuitryMonoaminergic inputAD patientsMolecular pathophysiologyHigh riskAssociated with deliriumPharmacological observationsDeliriumHigh risk of deliriumPreclinical studiesRisk of deliriumGuanfacineCarotid-Cavernous Fistula Treatment in Vascular Ehlers-Danlos Syndrome: A Case Report and Review of Management
Wong G, Pendharkar A, Lyman K, Thatikunta P, Kraler L, Mijalski C, Liang D, Dodd R. Carotid-Cavernous Fistula Treatment in Vascular Ehlers-Danlos Syndrome: A Case Report and Review of Management. Stroke 2023, 54: e403-e406. PMID: 37226776, DOI: 10.1161/strokeaha.123.042623.Peer-Reviewed Original ResearchCerebral Perfusion Imaging and Plateau Waves
Slawski D, Lyman K, Thatikunta P, Gold C, Albers G. Cerebral Perfusion Imaging and Plateau Waves. Stroke 2023, 54: e224-e228. PMID: 37021565, DOI: 10.1161/strokeaha.122.042274.Peer-Reviewed Original ResearchVaricella Zoster Vasculopathy Exacerbated by Tofacitinib in a Patient With Ulcerative Colitis
Lyman K, Sreekrishnan A, Thatikunta P, McConnell R, Lansberg M, Sells C. Varicella Zoster Vasculopathy Exacerbated by Tofacitinib in a Patient With Ulcerative Colitis. Stroke 2023, 54: e246-e250. PMID: 37021571, DOI: 10.1161/strokeaha.122.042228.Peer-Reviewed Original ResearchAn Electronic Health Record Intervention to Limit Viral Testing of Cerebrospinal Fluid
Lyman K, Madill E, Thatikunta P, Threlkeld Z, Banaei N, Gold C. An Electronic Health Record Intervention to Limit Viral Testing of Cerebrospinal Fluid. The Neurohospitalist 2023, 13: 173-177. PMID: 37064939, PMCID: PMC10091445, DOI: 10.1177/19418744231152103.Peer-Reviewed Original Research
2022
Discovery of a small-molecule inhibitor of the TRIP8b–HCN interaction with efficacy in neurons
Han Y, Iyamu I, Clutter M, Mishra R, Lyman K, Zhou C, Michailidis I, Xia M, Sharma H, Luan C, Schiltz G, Chetkovich D. Discovery of a small-molecule inhibitor of the TRIP8b–HCN interaction with efficacy in neurons. Journal Of Biological Chemistry 2022, 298: 102069. PMID: 35623388, PMCID: PMC9243175, DOI: 10.1016/j.jbc.2022.102069.Peer-Reviewed Original Research
2021
Hippocampal cAMP regulates HCN channel function on two time scales with differential effects on animal behavior
Lyman K, Han Y, Zhou C, Renteria I, Besing G, Kurz J, Chetkovich D. Hippocampal cAMP regulates HCN channel function on two time scales with differential effects on animal behavior. Science Translational Medicine 2021, 13: eabl4580. PMID: 34818058, PMCID: PMC9196047, DOI: 10.1126/scitranslmed.abl4580.Peer-Reviewed Original ResearchConceptsTetratricopeptide repeat-containing Rab8b-interacting proteinChronic stressCyclic adenosine monophosphateHippocampal cyclic adenosine monophosphateDepressive disorderMotivated behaviorDorsal hippocampusCognitive deficitsHCN channelsSpatial memoryChemogenetic technologyHyperpolarization-activated cyclic nucleotide-gated (HCN) channelsIntracellular cyclic adenosine monophosphateHCN channel functionTherapeutic targetChannel surface expressionCyclic adenosine monophosphate signalingHippocampalNeuronal excitabilityAnimal behaviorChannel functionSurface expressionAuxiliary subunitsSurface traffickingAdenosine monophosphate
Clinical Care
Overview
Clinical Specialties
Brain Injury; Neurocritical Care; Stroke
Board Certifications
Neurology
- Certification Organization
- AB of Psychiatry & Neurology
- Original Certification Date
- 2023
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Contacts
Email
Academic Office Number
Mailing Address
Yale Medicine
100 York Street
New Haven, CT 06511
United States