Kyle Lyman, MD, PhD
Assistant Professor of NeurologyCards
About
Research
Publications
2025
Angiographic perfusion outperforms large artery vasospasm for predicting the impact of rescue therapy in subarachnoid hemorrhage
Lyman K, Rubin D, Regenhardt R, Webb A, Rordorf G, Edlow B, Kimberly W, Du R, Snider S, Stapleton C, Patel A, Locascio J, Bevers M, Wu O, Chung D. Angiographic perfusion outperforms large artery vasospasm for predicting the impact of rescue therapy in subarachnoid hemorrhage. Journal Of Cerebral Blood Flow And Metabolism : Official Journal Of The International Society Of Cerebral Blood Flow And Metabolism 2025, 45: 2404-2416. PMID: 40719609, PMCID: PMC12303933, DOI: 10.1177/0271678x251361992.Peer-Reviewed Original ResearchConceptsEndovascular rescue therapyAneurysmal subarachnoid hemorrhageICA caliberInternal carotid arteryDigital subtraction angiographyRescue therapyVessel caliberPerfusion metricsSubarachnoid hemorrhageASAH outcomesTime-to-maximumAngiographic perfusionYounger patientsSubtraction angiographyClinical trialsVessel vasospasmCarotid arteryVasospasmBrain parenchymaMultivariate modelPerfusionHemorrhageTherapyPatientsCaliberImpaired Sphenoparietal Venous Drainage Is Associated With Increased Risk of Vasospasm in Aneurysmal Subarachnoid Hemorrhage
Lyman K, Adusumilli G, Kamdar H, Yang J, Rordorf G, Rubin D, Regenhardt R, Stapleton C, Patel A, Locascio J, Kimberly W, Edlow B, Heit J, Chung D. Impaired Sphenoparietal Venous Drainage Is Associated With Increased Risk of Vasospasm in Aneurysmal Subarachnoid Hemorrhage. Stroke Vascular And Interventional Neurology 2025, 5 DOI: 10.1161/svin.124.001539.Peer-Reviewed Original ResearchCortical vein opacification scoreAneurysmal subarachnoid hemorrhageCortical venous drainageRadiographic vasospasmVenous drainageAdequate venous drainageSubarachnoid hemorrhageSevere presentationHigh-grade aneurysmal subarachnoid hemorrhageSingle-center retrospective analysisComputed tomography angiogramImpaired venous drainageClearance of cerebrospinal fluidRisk of vasospasmPotential mechanistic linkLongitudinal Follow-upOpacification scoresRadiographic metricsCortical veinsClinical factorsHigher likelihoodPoor outcomeRetrospective analysisFollow-upPrognostic tool
2024
Characterization of hyperpolarization-activated cyclic nucleotide-gated channels in oligodendrocytes
Lyman K, Han Y, Robinson A, Weinberg S, Fisher D, Heuermann R, Lyman R, Kim D, Ludwig A, Chandel N, Does M, Miller S, Chetkovich D. Characterization of hyperpolarization-activated cyclic nucleotide-gated channels in oligodendrocytes. Frontiers In Cellular Neuroscience 2024, 18: 1321682. PMID: 38469353, PMCID: PMC10925711, DOI: 10.3389/fncel.2024.1321682.Peer-Reviewed Original ResearchExperimental autoimmune encephalomyelitisOligodendrocyte progenitor cellsHyperpolarization-activated cyclic nucleotide-gated (HCN) channelsHyperpolarization-activated cyclic nucleotide-gated channelsMature oligodendrocytesElectrophysiological characterizationVoltage-sensitive currentsCyclic Nucleotide-Gated ChannelsPlasticity of neural circuitsNucleotide-gated channelsCentral nervous systemAutoimmune encephalomyelitisHCN channelsMotor impairmentMyelin-forming cellsWild type counterpartsProgenitor cellsHCN2 channelsNonsense mutationOligodendrocyte lineageWhite matterNervous systemOligodendrocytesMiceNeural circuits
2023
A Molecular Framework for Delirium
Lyman K. A Molecular Framework for Delirium. The Neurohospitalist 2023, 14: 147-156. PMID: 38666272, PMCID: PMC11040633, DOI: 10.1177/19418744231207925.Peer-Reviewed Original ResearchAttention-deficit/hyperactivity disorderWorking memoryContext of attention-deficit/hyperactivity disorderDorsolateral prefrontal cortexDevelopment of pharmacotherapiesDelirious patientsAlzheimer's diseasePrefrontal cortexCognitive deficitsCognitive domainsPathophysiology of deliriumCognitive changesDLPFCNeural circuitryMonoaminergic inputAD patientsMolecular pathophysiologyHigh riskAssociated with deliriumPharmacological observationsDeliriumHigh risk of deliriumPreclinical studiesRisk of deliriumGuanfacineCarotid-Cavernous Fistula Treatment in Vascular Ehlers-Danlos Syndrome: A Case Report and Review of Management
Wong G, Pendharkar A, Lyman K, Thatikunta P, Kraler L, Mijalski C, Liang D, Dodd R. Carotid-Cavernous Fistula Treatment in Vascular Ehlers-Danlos Syndrome: A Case Report and Review of Management. Stroke 2023, 54: e403-e406. PMID: 37226776, DOI: 10.1161/strokeaha.123.042623.Peer-Reviewed Original ResearchCerebral Perfusion Imaging and Plateau Waves
Slawski D, Lyman K, Thatikunta P, Gold C, Albers G. Cerebral Perfusion Imaging and Plateau Waves. Stroke 2023, 54: e224-e228. PMID: 37021565, DOI: 10.1161/strokeaha.122.042274.Peer-Reviewed Original ResearchVaricella Zoster Vasculopathy Exacerbated by Tofacitinib in a Patient With Ulcerative Colitis
Lyman K, Sreekrishnan A, Thatikunta P, McConnell R, Lansberg M, Sells C. Varicella Zoster Vasculopathy Exacerbated by Tofacitinib in a Patient With Ulcerative Colitis. Stroke 2023, 54: e246-e250. PMID: 37021571, DOI: 10.1161/strokeaha.122.042228.Peer-Reviewed Original ResearchAn Electronic Health Record Intervention to Limit Viral Testing of Cerebrospinal Fluid
Lyman K, Madill E, Thatikunta P, Threlkeld Z, Banaei N, Gold C. An Electronic Health Record Intervention to Limit Viral Testing of Cerebrospinal Fluid. The Neurohospitalist 2023, 13: 173-177. PMID: 37064939, PMCID: PMC10091445, DOI: 10.1177/19418744231152103.Peer-Reviewed Original ResearchTesting of cerebrospinal fluidHerpes simplex virusPolymerase chain reactionLumbar punctureCerebrospinal fluidDiagnostic testsCase of herpes simplex virusViral polymerase chain reactionCerebrospinal fluid pathogensElectronic health record interventionPCR testPre-test probabilityBroad-spectrum antimicrobialsLeptomeningeal metastasesEmpirical treatmentAcademic medical centerSimplex virusNeurological emergencyRecord interventionsUnnecessary testingInpatient settingMedical CenterImmediate managementPCR panelHealthcare system
2022
Discovery of a small-molecule inhibitor of the TRIP8b–HCN interaction with efficacy in neurons
Han Y, Iyamu I, Clutter M, Mishra R, Lyman K, Zhou C, Michailidis I, Xia M, Sharma H, Luan C, Schiltz G, Chetkovich D. Discovery of a small-molecule inhibitor of the TRIP8b–HCN interaction with efficacy in neurons. Journal Of Biological Chemistry 2022, 298: 102069. PMID: 35623388, PMCID: PMC9243175, DOI: 10.1016/j.jbc.2022.102069.Peer-Reviewed Original ResearchConceptsTetratricopeptide repeat-containing Rab8b-interacting proteinHyperpolarization-activated cyclic nucleotide-gated (HCN) channelsPublic health problemNeuronal excitabilityHCN channelsSmall molecule inhibitorsDepressive disorderAuxiliary subunitsLifetime prevalenceTherapeutic targetChronic stressMammalian hippocampusHealth problemsCognitive impairmentHigh-throughput virtual screeningSmall molecules
2021
Hippocampal cAMP regulates HCN channel function on two time scales with differential effects on animal behavior
Lyman K, Han Y, Zhou C, Renteria I, Besing G, Kurz J, Chetkovich D. Hippocampal cAMP regulates HCN channel function on two time scales with differential effects on animal behavior. Science Translational Medicine 2021, 13: eabl4580. PMID: 34818058, PMCID: PMC9196047, DOI: 10.1126/scitranslmed.abl4580.Peer-Reviewed Original ResearchConceptsTetratricopeptide repeat-containing Rab8b-interacting proteinChronic stressCyclic adenosine monophosphateHippocampal cyclic adenosine monophosphateDepressive disorderMotivated behaviorDorsal hippocampusCognitive deficitsHCN channelsSpatial memoryChemogenetic technologyHyperpolarization-activated cyclic nucleotide-gated (HCN) channelsIntracellular cyclic adenosine monophosphateHCN channel functionTherapeutic targetChannel surface expressionCyclic adenosine monophosphate signalingHippocampalNeuronal excitabilityAnimal behaviorChannel functionSurface expressionAuxiliary subunitsSurface traffickingAdenosine monophosphate
Academic Achievements & Community Involvement
Clinical Care
Overview
Kyle Lyman, MD, PhD, is a neurologist specializing in neurocritical care, stroke, and brain injury. He focuses on diagnosing and treating complex neurological conditions that require intensive care, such as severe strokes and traumatic brain injuries. He uses a variety of medical approaches to support brain function and recovery in critically ill patients.
As an assistant professor of neurology at Yale School of Medicine, Dr. Lyman conducts research on the mechanisms underlying major neurological disorders. His work aims to improve patient outcomes through a deeper understanding of brain function and pathology.
Dr. Lyman completed his medical degree and a doctorate in neuroscience at Northwestern University. He pursued his neurology residency at Stanford University, followed by a fellowship in neurocritical care at Mass General Brigham.
Clinical Specialties
Brain Injury; Neurocritical Care; Stroke
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