Krasimira Rozenova, MD, PhD
she/her/hers
Assistant ProfessorAbout
Research
Publications
2026
178 Correlation Between PTEN Protein Expression by Immunohistochemical Staining and PTEN DNA Alterations in Advanced Breast Carcinoma
Matar S, Amraei R, Kahn A, Walther Z, Finberg K, Gibson J, Rozenova K, Kahila M. 178 Correlation Between PTEN Protein Expression by Immunohistochemical Staining and PTEN DNA Alterations in Advanced Breast Carcinoma. Laboratory Investigation 2026, 106: 104457. DOI: 10.1016/j.labinv.2025.104457.Peer-Reviewed Original Research177 Characterization of Frequency and Spectrum of AKT1 and PTEN Alterations in Advanced Breast Cancer
Matar S, Amraei R, Kahn A, Walther Z, Finberg K, Gibson J, Rozenova K, Kahila M. 177 Characterization of Frequency and Spectrum of AKT1 and PTEN Alterations in Advanced Breast Cancer. Laboratory Investigation 2026, 106: 104456. DOI: 10.1016/j.labinv.2025.104456.Peer-Reviewed Original Research1190 Acute Erythroid Leukemia Clonally Evolved from Myeloid Neoplasms
Fitzpatrick M, Yuan J, Akuma D, Allbee A, Bledsoe J, Capa I, Chen M, Chen P, Chen X, Cheng J, Gisriel S, Haque M, Hasserjian R, High Z, Hu Z, Lee W, Li P, Martin A, Matsumoto N, Medeiros L, Menon M, Pozdnyakova O, Rozenova K, Sadigh S, Shuai W, Silva O, Soma L, Sparger C, Sun Y, Tian X, Venkataraman G, Wang E, Wang H, Wang W, Wu X, Xie W, Xie Y, Yang G, Yang Y, Zhang L, Zhang S, Zhang X, Zhou J, Zhang J, Zhou X, Pan Z. 1190 Acute Erythroid Leukemia Clonally Evolved from Myeloid Neoplasms. Laboratory Investigation 2026, 106: 105482. DOI: 10.1016/j.labinv.2025.105482.Peer-Reviewed Original Research
2025
Application of hi-c sequencing to detect cryptic and novel structural aberrations in lymphoid neoplasms
Rozenova K, Sethi T, Kumar D, Braddock D, Xu M. Application of hi-c sequencing to detect cryptic and novel structural aberrations in lymphoid neoplasms. Blood 2025, 146: 4355. DOI: 10.1182/blood-2025-4355.Peer-Reviewed Original ResearchFluorescence in situ hybridizationB-cell lymphomaHigh-grade B-cell lymphomaDiffuse large B-cell lymphomaFormalin-fixed-paraffin-embeddedFluorescence in situ hybridization studiesHi-C sequencingHi-CBurkitt's lymphomaMYC rearrangementDNA segmentsLymphoid malignanciesLymphoid neoplasmsStructural variantsHigh-throughput chromosome conformation captureDetection of structural rearrangementsHistory of invasive breast carcinomaBreak-apart fluorescence in situ hybridizationAxillary lymph node biopsyDiagnosis of Burkitt's lymphomaClinical response to therapyLarge B-cell lymphomaHi-C analysisSequenced DNA segmentsChromosome conformation captureA 20‐color 21‐antigen flow cytometric assay for disease monitoring of T‐cell lymphoblastic leukemia
Gao Q, Zhang J, Rozenova K, Sun X, Burke A, Miu O, Nguyen N, Zhang S, Roshal M. A 20‐color 21‐antigen flow cytometric assay for disease monitoring of T‐cell lymphoblastic leukemia. Cytometry Part B Clinical Cytometry 2025, 108: 299-311. PMID: 40605707, DOI: 10.1002/cyto.b.22242.Peer-Reviewed Original ResearchConceptsT-lineage acute lymphoblastic leukemiaThymic precursorsAggressive neoplasmLymphoblastic leukemiaImmature T-cell phenotypeFlow cytometryT lymphoblastsEarly T-cell precursorT-cell lymphoblastic leukemiaEvaluation of mediastinal diseaseMinimal/measurable residual diseaseT-cell phenotypeTherapy decision-makingFollow-up measurementsImmature T cellsT cell precursorsAcute lymphoblastic leukemiaDisease monitoringResidual diseaseMediastinal diseaseT cellsFollow-upAntigenic changesNumerous antigensTissue samplesAtypical squamous proliferation diagnosed on biopsy has a high risk of representing squamous cell carcinoma
Rozenova K, Reed K, Guo R. Atypical squamous proliferation diagnosed on biopsy has a high risk of representing squamous cell carcinoma. JAAD International 2025, 20: 1-3. PMID: 40213529, PMCID: PMC11979433, DOI: 10.1016/j.jdin.2025.01.008.Peer-Reviewed Original ResearchGestational trophoblastic disease: STR genotyping for precision diagnosis
Rozenova K, Buza N, Hui P. Gestational trophoblastic disease: STR genotyping for precision diagnosis. Expert Review Of Molecular Diagnostics 2025, 25: 1-19. PMID: 39801212, DOI: 10.1080/14737159.2025.2453506.Peer-Reviewed Original ResearchConceptsShort tandem repeatsGestational trophoblastic diseaseShort tandem repeat genotypingDiagnosis of gestational trophoblastic diseaseGestational trophoblastic tumorsHydatidiform MoleSTR genotypingTrophoblastic tumorDifferential diagnosis of gestational trophoblastic diseaseRepetitive DNA sequencesManagement of gestational trophoblastic diseaseSubclassification of hydatidiform molesGestational trophoblastic neoplasmsPrognostication of patientsPaternity testingNon-neoplastic natureHuman genomeTandem repeatsDNA sequencesForensic identityTrophoblastic diseaseTrophoblastic neoplasmsGynecologic conditionsDiagnostic workupClinical outcomes
2023
Kappa Free Light Chain Drift Prompts the Need for a New Upper Limit of Normal Free Light Chain Ratio to Avoid an Epidemic of Kappa Light Chain Monoclonal Gammopathy of Undermined Significance
Rozenova K, Willrich M, Snyder M, Dasari S, Kourelis T, Rajkumar S, Kumar S, Dispenzieri A, Murray D. Kappa Free Light Chain Drift Prompts the Need for a New Upper Limit of Normal Free Light Chain Ratio to Avoid an Epidemic of Kappa Light Chain Monoclonal Gammopathy of Undermined Significance. The Journal Of Applied Laboratory Medicine 2023, 8: 742-750. PMID: 37232112, DOI: 10.1093/jalm/jfad027.Peer-Reviewed Original ResearchConceptsPlasma cell disorderFree light chainsSerum protein electrophoresisMonoclonal proteinFree light chain ratioFree light chain assayKappa free light chainsLight chain ratioDetection of monoclonal proteinsGroup of patientsProtein electrophoresisMASS-FIXMultiple laboratory testsFLC ratioCell disordersRetrospective studyImmunofixation electrophoresisPatientsChain ratioRFLCSerumLight chainMass spectrometryLaboratory testsElectrophoresisPrimary thymic marginal zone lymphoma with amyloidosis
Rozenova K, Xiao W. Primary thymic marginal zone lymphoma with amyloidosis. Blood 2023, 141: 1494-1494. PMID: 36951878, PMCID: PMC10082368, DOI: 10.1182/blood.2022019001.Peer-Reviewed Original ResearchDedifferentiation of B-lymphoblastic leukemia/lymphoma with t(9;22) BCR::ABL1 to an undifferentiated neoplasm with strong keratin expression in a patient receiving blinatumomab
Rozenova K, Roden A, Hartley C, Peterson J, Otteson G, Al-Kali A, Bayne H, Shah M, Patnaik M, King R, Larson D. Dedifferentiation of B-lymphoblastic leukemia/lymphoma with t(9;22) BCR::ABL1 to an undifferentiated neoplasm with strong keratin expression in a patient receiving blinatumomab. Human Pathology Reports 2023, 31: 300688. DOI: 10.1016/j.hpr.2022.300688.Peer-Reviewed Original ResearchAberrant keratin expressionB-ALLUndifferentiated neoplasmsKeratin expressionCases of lymphoblastic leukaemiaBone marrow relapseB-lymphoblastic leukemia/lymphomaMulti-agent therapyChest wall massInitiation of treatmentExpression of keratinMarrow relapseMyeloid antigensEarly relapseAcute leukemiaLymphoblastic leukemiaT cellsLineage switchKeratin-positiveBlinatumomabLineage-specific differentiationWall massNeoplasmsDedifferentiated neoplasmsBCR::ABL1
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BML35
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Brady Memorial Laboratory
310 Cedar Street
New Haven, CT 06510
Events
May 20269-11Multiple Days
Everyone Multi-session EventPei Hui, PhD, MD - Natalia Buza, MD - Krasimira Rozenova, MD, PhD - Deyin Xing, MD, PhD