Kathryn Fontaine
she/her/hers
Research Development Technician Imaging Research CenterCards
About
Research
Publications
2026
Characterization and Initial Optimization of Reconstruction Performance for Detector Crosstalk of Ultra-high Performance Brain PET Imager
Zhang J, Fontaine K, Li T, Gravel P, Toyonaga T, Hu Y, Gallezot J, Zeng T, Volpi T, Lu Y, Marin T, Qi J, Carson R. Characterization and Initial Optimization of Reconstruction Performance for Detector Crosstalk of Ultra-high Performance Brain PET Imager. IEEE Transactions On Radiation And Plasma Medical Sciences 2026, PP: 1-1. DOI: 10.1109/trpms.2026.3698769.Peer-Reviewed Original ResearchDepth of interactionDetector crosstalkSpatial resolutionHigh-resolution PET systemsCompton scatteringScintillation crystalsPET systemBrain phantomCrystal elementsPoint spread functionHigh-sensitivity requirementsOptical isolatorMeasured energyInteraction pointBrain PET imagingPET/CT systemReal phantomReconstruction performancePartial volume effectsImage contrastHigh image contrastSpread functionPhantomResolution characterizationCrosstalk eventsOptimization of brain PET markerless head motion correction in a large human cohort
Zeng T, Zhang J, Gallezot J, Fontaine K, Jiang W, Gravel P, Mulnix T, Naganawa M, Yang Z, Zhang X, Wang S, Sun X, Hu L, Carson R. Optimization of brain PET markerless head motion correction in a large human cohort. EJNMMI Physics 2026 PMID: 42213388, DOI: 10.1186/s40658-026-00885-1.Peer-Reviewed Original ResearchPost-reconstruction registrationMotion correctionBrain PETHead motion correctionCentroid of distributionMarkerless motion trackingUncorrected motionSiemens mCTIntentional facial expressionsStandardized uptake valueTime activity curvesFacial expressionsIterative Closest Points registrationMotion effectsFace regionImage resolutionUpper face regionCorrectionHuman studiesPoint registrationMotion trackingHead motionMotionAutomatic processingMeasured motionVariance reduction with synaptic density imaging in Parkinson’s disease using direct-4D PET image reconstruction
Gravel P, Gallezot J, Fontaine K, Matuskey D, Carson R. Variance reduction with synaptic density imaging in Parkinson’s disease using direct-4D PET image reconstruction. Physics In Medicine And Biology 2026, 71: 065007. PMID: 41825140, PMCID: PMC13014069, DOI: 10.1088/1361-6560/ae520a.Peer-Reviewed Original ResearchDose reduction for synaptic density PET imaging in Parkinson’s disease
Li A, Naganawa M, Honhar P, Fontaine K, Gravel P, Matuskey D, Carson R, Tang J. Dose reduction for synaptic density PET imaging in Parkinson’s disease. NeuroImage 2026, 331: 121853. PMID: 41833889, DOI: 10.1016/j.neuroimage.2026.121853.Peer-Reviewed Original ResearchHealthy controlsSubstantia nigraIn vivo quantificationPET imagingDeep imagingPET doseParkinson's diseaseFull-count dataSynaptic vesicle glycoprotein 2AC-UCB-JRecovery of correlationsDose reductionStandard doseNoise realizationsBrainstem nucleiRadiation exposureSynaptic densityRed nucleusMotor scoresDosePD patientsStatistical significanceClinical applicationBinding potentialDynamic PET
2025
Development and Initial Evaluation of 3D-Printed High Resolution Brain Phantom for PET
Lo C, Shanina E, Gravel P, Hu Y, Lucero S, Martins S, Mulnix T, Fontaine K, Nejati S, Sun X, Li H, Qi J, Cherry S, Carson R, Toyonaga T. Development and Initial Evaluation of 3D-Printed High Resolution Brain Phantom for PET. IEEE Transactions On Radiation And Plasma Medical Sciences 2025, 10: 603-610. PMID: 41446501, PMCID: PMC12724537, DOI: 10.1109/trpms.2025.3638588.Peer-Reviewed Original ResearchPET systemPET system performanceBrain PET systemHigh-resolution PET systemsSpatial resolutionSuperior spatial resolutionBrain phantomPhantom typesPhantom preparationPhantomReconstruction parametersRepositioning accuracyContrast modulationHuman brain anatomyReconstructed imagesMode dataContrast ratioImage resolutionHigh-resolution 3D printingResolutionAnatomical fidelityWhite matterGray matterModeFidelityPET Head Motion Estimation Using Supervised Deep Learning With Attention
Cai Z, Zeng T, Zhang J, Lieffrig E, Fontaine K, You C, Revilla E, Duncan J, Xin J, Lu Y, Onofrey J. PET Head Motion Estimation Using Supervised Deep Learning With Attention. IEEE Transactions On Medical Imaging 2025, 45: 1265-1278. PMID: 41082441, PMCID: PMC13097669, DOI: 10.1109/tmi.2025.3620714.Peer-Reviewed Original ResearchHead motion estimationMotion estimationState-of-the-artMotion estimation methodSupervised deep learningRigid head motionMotion correctionCross-attentionDelineation of brain structuresSupervised mannerDeep learningPositron emission tomography scannerMotion correction approachPET raw dataMotion trackingMotion-free imagesDiagnosis of neurological disordersQuantification inaccuraciesRaw dataHead motionBrain positron emission tomographyEstimation methodHead movementsMotion artifactsQualitative resultsYRT-PET: An Open-Source GPU-Accelerated Image Reconstruction Engine for Positron Emission Tomography
Najmaoui Y, Chemli Y, Toussaint M, Petibon Y, Marty B, Fontaine K, Gallezot J, Razdevsek G, Orehar M, Dhaynaut M, Guehl N, Dolenec R, Pestotnik R, Johnson K, Ouyang J, Normandin M, Tetrault M, Lecomte R, Fakhri G, Marin T. YRT-PET: An Open-Source GPU-Accelerated Image Reconstruction Engine for Positron Emission Tomography. IEEE Transactions On Radiation And Plasma Medical Sciences 2025, 10: 535-546. PMID: 41424471, PMCID: PMC12714321, DOI: 10.1109/trpms.2025.3619872.Peer-Reviewed Original ResearchThis study introduces YRT-PET, an open-source GPU-accelerated software for PET image reconstruction, demonstrating high flexibility, speed, and compatibility with existing tools for dynamic imaging and motion correction.Carotid Artery Image-Derived Blood Time-Activity Curves on the NeuroEXPLORER: Initial Multitracer Validation Against Arterial Sampling.
Volpi T, Gallezot J, Henry S, Dias M, Khattar N, Toyonaga T, Fontaine K, Mulnix T, Zhang J, Guo L, Gravel P, Radhakrishnan R, Hillmer A, Matuskey D, Carson R. Carotid Artery Image-Derived Blood Time-Activity Curves on the NeuroEXPLORER: Initial Multitracer Validation Against Arterial Sampling. Journal Of Nuclear Medicine 2025, 66: 1993-2001. PMID: 41043999, PMCID: PMC12676648, DOI: 10.2967/jnumed.125.270414.Peer-Reviewed Original ResearchConceptsArea under the curveCommon carotidTime-activity curvesLate area under the curveMethods:Carotid arteryRegions-of-interestResults:Blood samplesPartial volume effectsImage-derived input functionArterial blood samplesArterial input functionAlternative to arterial blood samplingBlood time-activity curvesPET kinetic modelingGold standardInput functionBackground activityArterial samplesCarotidBrain-dedicated PET scannersBrain PET
2024
Fluoride transport in Arabidopsis thaliana plants is impaired in Fluoride EXporter (FEX) mutants
Tausta S, Fontaine K, Hillmer A, Strobel S. Fluoride transport in Arabidopsis thaliana plants is impaired in Fluoride EXporter (FEX) mutants. Plant Molecular Biology 2024, 114: 17. PMID: 38342783, PMCID: PMC10859346, DOI: 10.1007/s11103-023-01413-w.Peer-Reviewed Original ResearchConceptsFluoride exportMutant plantsWT plantsArabidopsis thaliana plantsSingle cell eukaryotesMulticellular plantsThaliana plantsCell eukaryotesFluoride toleranceTerminal tissuesMutantsFluoride transportPlantsFloral stemsWildtypeArabidopsisEukaryotesEnvironmental toxinsStemBacteriaPositron emission tomographyPrimary locusToxin
2023
Markerless head motion tracking and event-by-event correction in brain PET
Zeng T, Lu Y, Jiang W, Zheng J, Zhang J, Gravel P, Wan Q, Fontaine K, Mulnix T, Jiang Y, Yang Z, Revilla E, Naganawa M, Toyonaga T, Henry S, Zhang X, Cao T, Hu L, Carson R. Markerless head motion tracking and event-by-event correction in brain PET. Physics In Medicine And Biology 2023, 68: 245019. PMID: 37983915, PMCID: PMC10713921, DOI: 10.1088/1361-6560/ad0e37.Peer-Reviewed Original ResearchConceptsPoint source studyHead motion correctionSmaller residual displacementMotion correctionIterative closest point (ICP) registration algorithmHead motion trackingSpatial resolutionResidual displacementData-driven evaluation methodHigh spatial resolutionLow noiseMotion trackingStereovision cameraMotion tracking deviceStructured lightEvent correctionBrain positron emission tomography (PET) imagingTracking deviceReconstruction resultsHMT methodPoint cloudsNegative biasReference cloudUMTEvaluation method
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