Jiyeon Kim, PhD
Assistant Professor of Urology and Cellular & Molecular PhysiologyCards
About
Research
Publications
2025
High KYNU Expression Is Associated with Poor Prognosis, KEAP1/STK11 Mutations, and Immunosuppressive Metabolism in Patient-Derived but Not Murine Lung Adenocarcinomas
Cai L, Rogers T, Jafarabad R, Vu H, Yang C, Novaresi N, Galán-Cobo A, Girard L, Ostrin E, Fahrmann J, Kim J, Heymach J, O’Donnell K, Xiao G, Xie Y, DeBerardinis R, Minna J. High KYNU Expression Is Associated with Poor Prognosis, KEAP1/STK11 Mutations, and Immunosuppressive Metabolism in Patient-Derived but Not Murine Lung Adenocarcinomas. Cancers 2025, 17: 1681. PMID: 40427178, PMCID: PMC12109616, DOI: 10.3390/cancers17101681.Peer-Reviewed Original ResearchAmino acids in cancer: Understanding metabolic plasticity and divergence for better therapeutic approaches
K. L, Lee H, Ha Y, Lee C, Kim J. Amino acids in cancer: Understanding metabolic plasticity and divergence for better therapeutic approaches. Cell Reports 2025, 44: 115529. PMID: 40193251, PMCID: PMC12038367, DOI: 10.1016/j.celrep.2025.115529.Peer-Reviewed Original ResearchPDK4 expression and tumor aggressiveness in prostate cancer
Lee E, Ha Y, Yoon B, Jeon M, Park D, Kim J, Kang J, Chung J, Kim B, Choi S, Kim H, Kim T, Yoo E, Kwon T. PDK4 expression and tumor aggressiveness in prostate cancer. Investigative And Clinical Urology 2025, 66: 227-235. PMID: 40312902, PMCID: PMC12058538, DOI: 10.4111/icu.20240434.Peer-Reviewed Original Research
2024
Single‑center, retrospective, evaluator‑blinded, pilot and pivotal clinical trials: Assessing the mirCaP Kit (hsv2‑miR‑H9/hsa‑miR‑3659) as a diagnostic marker for prostate cancer in patients with PSA levels in the gray zone
Kim W, Kim K, Kang H, Byun Y, Piao X, Kim Y, Lee S, Yun S, Ha Y, Kim J, Kim I. Single‑center, retrospective, evaluator‑blinded, pilot and pivotal clinical trials: Assessing the mirCaP Kit (hsv2‑miR‑H9/hsa‑miR‑3659) as a diagnostic marker for prostate cancer in patients with PSA levels in the gray zone. Oncology Letters 2024, 29: 23. PMID: 39512501, PMCID: PMC11542165, DOI: 10.3892/ol.2024.14770.Peer-Reviewed Original Research635 Intraoperative 13C-glucose tracing and metabolomics of patient melanoma tumors reveal metabolic features associated with aggressive melanomas
Gill J, Rao A, Walsdorf R, Snyman M, Wix S, Brown A, Gard G, Kim J, Patricio J, Zacharias L, Solmonson A, Tillman B, Sharma R, Vandergriff T, Mathews T, Cai L, DeBerardinis R. 635 Intraoperative 13C-glucose tracing and metabolomics of patient melanoma tumors reveal metabolic features associated with aggressive melanomas. Journal Of Investigative Dermatology 2024, 144: s110. DOI: 10.1016/j.jid.2024.06.651.Peer-Reviewed Original ResearchConcurrent loss of LKB1 and KEAP1 enhances SHMT-mediated antioxidant defence in KRAS-mutant lung cancer
Lee H, Muhammad N, Lieu E, Cai F, Mu J, Ha Y, Cao G, Suchors C, Joves K, Chronis C, Li K, Ducker G, Olszewski K, Cai L, Allison D, Bachert S, Ewing W, Wong H, Seo H, Kim I, Faubert B, Kim J, Kim J. Concurrent loss of LKB1 and KEAP1 enhances SHMT-mediated antioxidant defence in KRAS-mutant lung cancer. Nature Metabolism 2024, 6: 1310-1328. PMID: 38877143, PMCID: PMC11809267, DOI: 10.1038/s42255-024-01066-z.Peer-Reviewed Original ResearchAMP-Activated Protein Kinase KinasesAnimalsAntioxidantsCarcinoma, Non-Small-Cell LungCell Line, TumorGlycine HydroxymethyltransferaseHumansKelch-Like ECH-Associated Protein 1Lung NeoplasmsMiceMutationNF-E2-Related Factor 2Oxidative StressProtein Serine-Threonine KinasesProto-Oncogene Proteins p21(ras)
2023
A century of the Warburg effect
Thompson C, Vousden K, Johnson R, Koppenol W, Sies H, Lu Z, Finley L, Frezza C, Kim J, Hu Z, Bartman C. A century of the Warburg effect. Nature Metabolism 2023, 5: 1840-1843. PMID: 37990075, DOI: 10.1038/s42255-023-00927-3.Peer-Reviewed Original ResearchMAD2-Dependent Insulin Receptor Endocytosis Regulates Metabolic Homeostasis.
Park J, Hall C, Hubbard B, LaMoia T, Gaspar R, Nasiri A, Li F, Zhang H, Kim J, Haeusler R, Accili D, Shulman G, Yu H, Choi E. MAD2-Dependent Insulin Receptor Endocytosis Regulates Metabolic Homeostasis. Diabetes 2023, 72: 1781-1794. PMID: 37725942, PMCID: PMC10658066, DOI: 10.2337/db23-0314.Peer-Reviewed Original ResearchConceptsIR endocytosisInsulin receptor endocytosisCell division regulatorsInsulin receptorProlongs insulin actionReceptor endocytosisTranscriptomic profilesInsulin stimulationEndocytosisMetabolic homeostasisCell surfaceGenetic ablationMetabolic functionsInsulin actionP31cometMad2BubR1DisruptionSignalingRegulatorHomeostasisAdipose tissueInteractionHepatic fat accumulationMetabolismMachine learning based prediction for oncologic outcomes of renal cell carcinoma after surgery using Korean Renal Cell Carcinoma (KORCC) database
Kim J, Lee S, Hong S, Kwak C, Jeong C, Kang S, Hong S, Kim Y, Chung J, Hwang E, Kwon T, Byun S, Jung Y, Lim J, Kim J, Oh H. Machine learning based prediction for oncologic outcomes of renal cell carcinoma after surgery using Korean Renal Cell Carcinoma (KORCC) database. Scientific Reports 2023, 13: 5778. PMID: 37031280, PMCID: PMC10082844, DOI: 10.1038/s41598-023-30826-2.Peer-Reviewed Original ResearchE2F regulation of the Phosphoglycerate kinase gene is functionally important in Drosophila development
Zappia M, Kwon Y, Westacott A, Liseth I, Lee H, Islam A, Kim J, Frolov M. E2F regulation of the Phosphoglycerate kinase gene is functionally important in Drosophila development. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2220770120. PMID: 37011211, PMCID: PMC10104548, DOI: 10.1073/pnas.2220770120.Peer-Reviewed Original ResearchConceptsE2F regulationMetabolic genesE2F sitesTarget genesTranscription factor E2FExpression of cell cycle genesE2F target genesAbnormal mitochondrial morphologyPhosphoglycerate kinase geneCell cycle genesHighest energy consumer organDrosophila developmentGenomic regionsChromatin accessibilityMitochondrial morphologyCanonical roleGlycolytic genesCycle genesE2FKinase geneAdenosine triphosphateGlycolytic fluxE2F targetsGene expressionGenes
Academic Achievements & Community Involvement
News
News
- July 29, 2025
Yale Urology Research [Q2: April-June 2025]
- April 14, 2025Source: Cell Reports
Amino Acids in Cancer: Understanding Metabolic Plasticity and Divergence for Better Therapeutic Approaches
- January 16, 2025
Yale Urology Research [Q4: October-December 2024]
- July 31, 2024
Yale Urology Research [Q2: April-June 2024]
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