Jim Ho, MD
Clinical FellowCards
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Research
Publications
2025
Reply to: Reevaluating Functional Recovery Post‐COVID‐19: A Call for Broader Considerations
Ho J, McAvay G, Murphy T, Acampora D, Araujo K, Geda M, Gill T, Hajduk A, Cohen A, Ferrante L. Reply to: Reevaluating Functional Recovery Post‐COVID‐19: A Call for Broader Considerations. Journal Of The American Geriatrics Society 2025 PMID: 40390544, PMCID: PMC12353894, DOI: 10.1111/jgs.19534.Peer-Reviewed Original ResearchFunctional Trajectories After COVID‐19 Hospitalization Among Older Adults
Ho J, McAvay G, Murphy T, Acampora D, Araujo K, Geda M, Gill T, Hajduk A, Cohen A, Ferrante L. Functional Trajectories After COVID‐19 Hospitalization Among Older Adults. Journal Of The American Geriatrics Society 2025, 73: 1733-1741. PMID: 40096163, PMCID: PMC12213203, DOI: 10.1111/jgs.19420.Peer-Reviewed Original ResearchConceptsIn-hospital deliriumFunction trajectoriesFactors associated with trajectory membershipTrajectory membershipAssociation of potential risk factorsCommunity-dwelling adultsRisk factorsModifiable risk factorsMedical decision-makingOlder survivorsPotential risk factorsOlder adultsSeverity of illnessAssociated with membershipYears of ageCOVID-19 hospitalizationModerate trajectoryLatent class analysisMultinomial regressionSurvive hospitalizationCOVID-19DisabilitySeverity trajectoriesHospitalClass analysis
2024
Peak expiratory flow predicts motoric cognitive risk syndrome: A cohort study
Ho J, Kuschner W, Verghese J. Peak expiratory flow predicts motoric cognitive risk syndrome: A cohort study. Journal Of The American Geriatrics Society 2024, 73: 887-893. PMID: 39382106, PMCID: PMC11908954, DOI: 10.1111/jgs.19210.Peer-Reviewed Original ResearchConceptsMotoric cognitive risk syndromeIncident MCRNational Health and Aging Trends StudyLow peak expiratory flowAssociated with higher prevalencePeak expiratory flowIncidence of MCRPrevalence of motoric cognitive risk syndromeRisk syndromePercentile groupHealth-related covariatesDiscrete-time proportional hazards modelsRisk factorsModifiable risk factorsCohort of adultsSubjective cognitive complaintsPoor respiratory functionYears of follow-upSlow gaitPredementia syndromesProportional hazards modelTrends StudyLongitudinal associationsYears of ageCognitive complaintsSex-specific outcomes in cancer therapy: the central role of hormones
Bakhshi P, Ho J, Zanganeh S. Sex-specific outcomes in cancer therapy: the central role of hormones. Frontiers In Medical Technology 2024, 6: 1320690. PMID: 38362126, PMCID: PMC10867131, DOI: 10.3389/fmedt.2024.1320690.Peer-Reviewed Original ResearchHormone replacement therapyHormone-sensitive cancersSex hormonesTreatment outcomesCancer therapyCancer progressionEstrogen receptor-negativeEstrogen receptor-positiveAndrogen receptor signalingSex-specific outcomesInhibit cancer progressionReceptor-negativeReceptor-positiveAromatase inhibitorsReplacement therapyTreatment responseAnti-androgenHormone levelsTherapeutic outcomesPersonalized therapyHormonal profileReceptor signalingTherapyCancer treatmentCancer
2023
PEAK EXPIRATORY FLOW AND MOTORIC COGNITIVE RISK SYNDROME
HO J, VERGHESE J. PEAK EXPIRATORY FLOW AND MOTORIC COGNITIVE RISK SYNDROME. CHEST Journal 2023, 164: a5817. DOI: 10.1016/j.chest.2023.07.3750.Peer-Reviewed Original ResearchFerroptosis: Environmental causes, biological redox signaling responses, cancer and other health consequences
Sepand M, Bigdelou B, Maghsoudi A, Sanadgol N, Ho J, Chauhan P, Raoufi M, Kermanian A, Esfandyarpour R, Hajipour M, Zanganeh S. Ferroptosis: Environmental causes, biological redox signaling responses, cancer and other health consequences. Coordination Chemistry Reviews 2023, 480: 215024. DOI: 10.1016/j.ccr.2023.215024.Peer-Reviewed Original ResearchReactive oxygen speciesCell deathPyridine nucleotide redox systemsRegulation of cell fateReactive oxygen species signalingIron-mediated cell deathTrigger cell deathCellular redox signalingCell fateEffects of environmental chemical exposureProtein activityRedox messengersRedox signalingCell metabolismHuman diseasesROS amountsImpact of ferroptosisIntracellular levelsChemical stressorsExposure to xenobioticsOxygen speciesRedox statusFerroptosisNormal metabolismCell statusDesigning and developing a sensitive and specific SARS-CoV-2 RBD IgG detection kit for identifying positive human samples
Raoufi E, Hosseini F, Onagh B, Salehi-Shadkami M, Mehrali M, Mohsenzadegan M, Ho J, Bigdelou B, Sepand M, Webster T, Zanganeh S, Farajollahi M. Designing and developing a sensitive and specific SARS-CoV-2 RBD IgG detection kit for identifying positive human samples. Clinica Chimica Acta 2023, 542: 117279. PMID: 36871661, PMCID: PMC9985519, DOI: 10.1016/j.cca.2023.117279.Peer-Reviewed Original ResearchConceptsReceptor-binding domainPichia pastorisIon-exchange chromatographyShake flask cultivationRecombinant receptor-binding domainSARS-CoV-2 spike proteinBioreactor cultivationsIndirect enzyme-linked immunoassayBinding domainSARS-CoV-2Target proteinsProtein productionTarget genesAntigenic regionsEnzyme-linked immunoassaySpike proteinProteinReceptor binding domain antigensDetection kitEpitope analysisHuman samplesEnzyme-linked immunoassay testImmunological developmentCultivationHuman serum
2022
Clinical Consequences of Metabolic Acidosis—Muscle
Ho J, Abramowitz M. Clinical Consequences of Metabolic Acidosis—Muscle. Advances In Kidney Disease And Health 2022, 29: 395-405. PMID: 36175077, DOI: 10.1053/j.ackd.2022.04.010.Peer-Reviewed Original ResearchConceptsMetabolic acidosisImpact of metabolic acidosisAdverse clinical outcomesChronic kidney diseaseDecreased oxidative phosphorylationPhysical functionImpaired protein synthesisClinical outcomesOxidative phosphorylationMitochondrial functionProtein degradationFunctional outcomesKidney diseaseAcidosisProtein synthesisMuscle breakdownFunctional declineReduced energy productionMuscle contractionSkeletal muscleMusclePathwayOutcomesSerum bicarbonate levels and gait abnormalities in older adults: a cross-sectional study
Ho J, Verghese J, Abramowitz M. Serum bicarbonate levels and gait abnormalities in older adults: a cross-sectional study. Scientific Reports 2022, 12: 9171. PMID: 35654910, PMCID: PMC9163170, DOI: 10.1038/s41598-022-12907-w.Peer-Reviewed Original ResearchConceptsAssociated with worse performanceOlder adultsGait abnormalitiesGait variabilityAssociated with gait abnormalitiesAssociated with impaired physical functionQuantitative measures of gaitDouble support timeMeasures of gaitQuantitative gait analysisShorter stride lengthCommunity-dwelling adultsImpaired physical functionSevere gait abnormalitiesChronic kidney diseaseAssociation of serum bicarbonateCross-sectional studyGait analysisStride lengthPhysical functionSupport timeWorse performanceMiddle tertileMultivariable adjustmentGaitCOVID-19 and Preexisting Comorbidities: Risks, Synergies, and Clinical Outcomes
Bigdelou B, Sepand M, Najafikhoshnoo S, Negrete J, Sharaf M, Ho J, Sullivan I, Chauhan P, Etter M, Shekarian T, Liang O, Hutter G, Esfandiarpour R, Zanganeh S. COVID-19 and Preexisting Comorbidities: Risks, Synergies, and Clinical Outcomes. Frontiers In Immunology 2022, 13: 890517. PMID: 35711466, PMCID: PMC9196863, DOI: 10.3389/fimmu.2022.890517.Peer-Reviewed Original ResearchConceptsCo-existing diseasesOptimal management of patientsManagement of patientsCOVID-19 clinical outcomesHost-viral interactionsClinical outcomesSevere acute respiratory syndrome coronavirus 2Severe infectionsMinimal symptomsAcute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2Immune responseOptimal managementPutative signaling pathwaysSyndrome coronavirus 2Cardiovascular diseaseSevere outcomesCoronavirus disease 2019PatientsSARS-CoV-2Medical consequencesDiseaseSignaling pathwayCoronavirus 2COVID-19
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