Jessica Magid-Bernstein, MD, PhD
Assistant Professor of NeurologyDownloadHi-Res Photo
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Appointments
Neurology
Primary
Publications Overview
- 27 Publications
- 976 Citations
- 23 Yale Co-Authors
About
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Titles
Assistant Professor of Neurology
Biography
Dr. Magid-Bernstein completed her MD and PhD with a focus in immunology at Rutgers University – New Jersey Medical School in Newark, NJ in 2015. She then went on to complete her medical internship and residency training in Neurology at New York Presbyterian – Columbia University Medical Center, followed by a fellowship in Neurocritical Care at New York Presbyterian – Columbia University Medical Center & Weill Cornell Medicine before joining the Yale Department of Neurology Division of Neurocritical Care and Emergency Neurology in 2021.
Dr. Magid-Bernstein is dedicated to taking care of complex neurocritically ill patients during her clinical time in the NeuroICU at Yale. When she is not on clinical service, she is developing a research career focused on understanding the role that inflammation plays in outcomes following intracerebral hemorrhage and subarachnoid hemorrhage. Her research was previously supported by an Neurocritical Care Society Research Fellowship Grant (2021-2022) and by an American Heart Association Career Development Award (2023-2026). In 2025, she was awarded a K23 grant by the National Institutes of Health/National Institute of Neurological Disorders and Stroke.
Last Updated on May 26, 2026.
Appointments
Neurology
Assistant ProfessorPrimary
Other Departments & Organizations
- Center for Brain & Mind Health
- Janeway Society
- Magid-Bernstein Lab
- Neurocritical Care & Emergency Surgery
- Neurology
- Yale Medicine
- Yale New Haven Health System
Education & Training
- Fellow
- NY Presbyterian - Columbia University Medical Center/Weill Cornell Medicine (2021)
- Resident
- NY Presbyterian - Columbia University Medical Center (2019)
- Intern
- NY Presbyterian - Columbia University Medical Center (2016)
- MD
- Rutgers University - New Jersey Medical School (2015)
- PhD
- University of Medicine and Dentistry of NJ - New Jersey Medical School (2013)
- BA
- Haverford College (2006)
Research
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Overview
Medical Research Interests
Cerebral Intraventricular Hemorrhage; Inflammation; Intracranial Hemorrhages; Subarachnoid Hemorrhage
ORCID
0000-0001-6506-6017- View Lab Website
Magid-Bernstein lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of Jessica Magid-Bernstein's published research.
Publications Timeline
A big-picture view of Jessica Magid-Bernstein's research output by year.
Research Interests
Research topics Jessica Magid-Bernstein is interested in exploring.
Emily J. Gilmore, MD, FNCS, FACNS
Guido J. Falcone, ScD, MPH
Kevin Sheth, MD, FAHA
Charles Matouk, MD
Jennifer Ahjin Kim, MD, PhD
Lauren Hachmann Sansing, MD, MS, FAHA, FANA
27Publications
976Citations
Subarachnoid Hemorrhage
Publications
Featured Publications
Cerebral Hemorrhage: Pathophysiology, Treatment, and Future Directions
Magid-Bernstein J, Girard R, Polster S, Srinath A, Romanos S, Awad IA, Sansing LH. Cerebral Hemorrhage: Pathophysiology, Treatment, and Future Directions. Circulation Research 2022, 130: 1204-1229. PMID: 35420918, PMCID: PMC10032582, DOI: 10.1161/circresaha.121.319949.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricMeSH Keywords and ConceptsConceptsMechanism of injuryIntracerebral hemorrhageUltra-early hemostatic therapyInflammatory brain injuryCurrent treatment strategiesIron-induced injuryAnticoagulant useHemostatic therapyHemorrhagic strokeHypertension managementICH therapySurgical managementHigh morbidityPrimary preventionFunctional outcomeICH managementBrain injuryClinical trialsTreatment strategiesPrognostic biomarkerDevastating formDisease pathobiologyInjuryInvasive surgeryOxidative stressImpacts of ABO-incompatible platelet transfusions on platelet recovery and outcomes after intracerebral hemorrhage
Magid-Bernstein J, Beaman CB, Carvalho-Poyraz F, Boehme A, Hod EA, Francis RO, Elkind MSV, Agarwal S, Park S, Claassen J, Connolly ES, Roh D. Impacts of ABO-incompatible platelet transfusions on platelet recovery and outcomes after intracerebral hemorrhage. Blood 2021, 137: 2699-2703. PMID: 33649761, PMCID: PMC9635530, DOI: 10.1182/blood.2020008381.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsABO-incompatible platelet transfusionsIntracerebral hemorrhagePlatelet transfusionsPlatelet recoveryABO-compatible transfusionsSingle-center cohortOdds of mortalityABO-incompatible transfusionLow platelet recoveryNeurological outcomeOngoing bleedingABO compatibilityICH outcomeMedication effectsTransfusionPoor mRSPatientsHemorrhageOutcomesUnderlying mechanismFurther investigationBleedingCohortMortalityRecoveryCerebral Microbleeds and Acute Hematoma Characteristics in the ATACH-2 and MISTIE III Trials
Magid-Bernstein JR, Li Y, Cho SM, Piran PJ, Roh DJ, Gupta A, Shoamanesh A, Merkler A, Zhang C, Avadhani R, Montano N, Iadecola C, Falcone G, Sheth K, Qureshi AI, Rosand J, Goldstein J, Awad I, Hanley D, Kamel H, Ziai WC, Murthy SB. Cerebral Microbleeds and Acute Hematoma Characteristics in the ATACH-2 and MISTIE III Trials. Neurology 2021, 98: e1013-e1020. PMID: 34937780, PMCID: PMC8967392, DOI: 10.1212/wnl.0000000000013247.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSmaller ICH volumeCerebral microbleedsSmall vessel diseaseIntracerebral hemorrhageHematoma expansionHematoma characteristicsICH volumeVessel diseaseNumber of CMBsSmaller baseline hematoma volumesUnderlying small vessel diseasePresence of CMBsCerebral small vessel diseaseAdmission ICH volumeMISTIE III trialPresence of microbleedsClass II evidencePhase 3 trialSeverity of leukoaraiosisPrimary intracerebral hemorrhageBaseline hematoma volumeIndividual patient dataBrain MRI scansLogistic regression modelsAntihypertensive treatmentEarly CSF inflammatory markers after aneurysmal subarachnoid hemorrhage and their relationship to disease severity and shunt placement
Magid-Bernstein J, Yan J, Herman A, He Z, Johnson C, Beatty H, Choi R, Velazquez S, Sorensen G, Jayasundara S, Grychowski L, Amllay A, Falcone G, Kim J, Petersen N, O’Keefe L, Gilmore E, Matouk C, Sheth K, Sansing L. Early CSF inflammatory markers after aneurysmal subarachnoid hemorrhage and their relationship to disease severity and shunt placement. Journal Of Stroke And Cerebrovascular Diseases 2025, 34: 108395. PMID: 40639751, PMCID: PMC12333380, DOI: 10.1016/j.jstrokecerebrovasdis.2025.108395.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsPermanent shunt placementAneurysmal subarachnoid hemorrhage patientsGranulocyte-colony stimulating factorAneurysmal subarachnoid hemorrhageVascular endothelial growth factorCC motif chemokine ligand 2Shunt placementCerebrospinal fluidCerebrospinal fluid samplesInterleukin-6Interleukin-8Disease severityPreclinical modelsSubarachnoid hemorrhageModified Fisher scale scoresModels of CNS inflammationShunt-dependent hydrocephalusAssociated with clinical severityConcentrations of interleukin-6Post-hemorrhagic hydrocephalusMotif chemokine ligand 2Panel of cytokinesCSF inflammatory markersEndothelial growth factorCerebrospinal fluid concentrationsOperationalizing a complex acute clinical trial: Lessons from the BEACH study
Sorensen G, Remillard W, Schlechter M, Kampp M, Brady C, Kildahl K, Mould A, Ziai W, Lane K, Van Eldik L, Distasio A, Lu J, Sansing L, Hanley D, Magid-Bernstein J. Operationalizing a complex acute clinical trial: Lessons from the BEACH study. Journal Of Clinical And Translational Science 2025, 9: e215. PMID: 41040632, PMCID: PMC12485565, DOI: 10.1017/cts.2025.10152.Peer-Reviewed Original ResearchCitationsConceptsNeuroscience intensive care unitPatient careYale-New Haven HospitalCare delivery teamPatient care environmentInterdisciplinary collaborationPatient safetyCare environmentDelivery teamSchool of MedicineClinical trial protocolsUniversity School of MedicineIntracerebral hemorrhageIntensive care unitPatient outcomesCareMultidisciplinary collaborationTrial protocolResearch teamNew Haven HospitalCare unitPatient enrollmentSignals of efficacyYale University School of MedicineInnovative treatment strategies
2026
Evaluating the Effects of Endovascular Interventions on the Incidence of Epileptiform Abnormalities in Aneurysmal Subarachnoid Hemorrhage Patients (P9-18.009)
Maarek R, Stoehr K, Jayasundara S, Estrella D, Choi R, Rapuano A, Jin Z, Jing J, Sun C, Koo A, Chen Y, Magid-Bernstein J, O’Keefe L, Bahrassa F, Hebert R, Westover B, Matouk C, Petersen N, Gilmore E, Kim J. Evaluating the Effects of Endovascular Interventions on the Incidence of Epileptiform Abnormalities in Aneurysmal Subarachnoid Hemorrhage Patients (P9-18.009). Neurology 2026, 106 DOI: 10.1212/wnl.0000000000217401.Peer-Reviewed Original ResearchCytokine markers in intracerebral hemorrhage are linked to ventricular imaging and outcomes
Sorensen G, Grychowski L, Yan J, Remillard W, Lidman A, Edwards T, Herman A, Johnson C, Sheth K, Matouk C, Falcone G, Gilmore E, Payabvash S, Sansing L, Magid-Bernstein J. Cytokine markers in intracerebral hemorrhage are linked to ventricular imaging and outcomes. Journal Of Stroke And Cerebrovascular Diseases 2026, 35: 108663. PMID: 42167563, PMCID: PMC13292057, DOI: 10.1016/j.jstrokecerebrovasdis.2026.108663.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsAssociated with ventricular enlargementModified Rankin ScaleExternal ventricular drainIntracerebral hemorrhage patientsCentral nervous systemIntracerebral hemorrhageCerebrospinal fluidVentricular enlargementComputed tomographyFunctional outcomesInterleukin-6Interleukin-8Granulocyte colony-stimulating factorCentral nervous system inflammationCC motif chemokine ligand 2Cerebrospinal fluid cytokinesVascular endothelial growth factor AMotif chemokine ligand 2Colony-stimulating factorBiomarkers of disease progressionEndothelial growth factor ACentral inflammatory responseChemokine ligand 2Growth factor AVentricular volume changesMultiple Opportunistic Infections as the Initial Presentation of Human Immunodeficiency Virus (HIV)/Acquired Immunodeficiency Syndrome (AIDS) in an Ecuadorian Immigrant
Alappan U, Klug T, Magid-Bernstein J, Huttner A, Vinetz J. Multiple Opportunistic Infections as the Initial Presentation of Human Immunodeficiency Virus (HIV)/Acquired Immunodeficiency Syndrome (AIDS) in an Ecuadorian Immigrant. Cureus 2026, 18: e106368. PMID: 41938672, PMCID: PMC13049230, DOI: 10.7759/cureus.106368.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus (HIV)/acquired immunodeficiency syndromeOpportunistic infectionsImmunodeficiency syndromeMultiple opportunistic infectionsEffective antiretroviral therapyPreventing opportunistic infectionsDisseminated histoplasmosisEpigastric painAntiretroviral therapyHIV screeningHIV infectionCerebral toxoplasmosisBrain infectionInfectionSexual historyWeight lossHIVSyndromeEcuadorian manMissed opportunitiesHistoplasmosisPainVomitingTherapyFeverCharacterizing inflammatory biomarkers in post-stroke seizure risk and outcome prognostication
Wang E, Misra S, Yan J, Chook P, Kawamura Y, Kitagawa R, Kim J, Gilmore E, de Havenon A, Sivaraju A, Hirsch L, Falcone G, Rangaraju S, Sansing L, Magid-Bernstein J, Mishra N. Characterizing inflammatory biomarkers in post-stroke seizure risk and outcome prognostication. PLOS ONE 2026, 21: e0345752. PMID: 41915645, PMCID: PMC13038000, DOI: 10.1371/journal.pone.0345752.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsIntracerebral hemorrhage volumeDays post-ICHIntracerebral hemorrhageLobar intracerebral hemorrhagePost-stroke seizuresPost-ICHCCL2 levelsEpileptiform dischargesInflammatory biomarkersMultivariate analysisOdds ratioAssociated with poor outcomesMultivariate logistic regression analysisCytometric bead arrayRetrospective cohort studyYale-New Haven HospitalPlasma biomarker levelsLogistic regression analysisClinical seizuresOutcome prognosticationNew Haven HospitalUnivariate analysisPoor outcomeBead arrayCohort studyAutoregulation-Guided Blood Pressure Targets After Stroke Thrombectomy
Petersen N, Begunova Y, Olexa M, Kumar A, Chen Y, Dhar R, Falcone G, Gilmore E, Kim J, Magid-Bernstein J, de Havenon A, Marshall R, Miller E, Matouk C, Hebert R, Sheth K, Ortega-Gutierrez S. Autoregulation-Guided Blood Pressure Targets After Stroke Thrombectomy. Neurology 2026, 106: e214577. PMID: 41512207, PMCID: PMC12952690, DOI: 10.1212/wnl.0000000000214577.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsLimits of autoregulationSecondary brain injuryProspective observational studyRadiographic biomarkersFunctional outcomesEndovascular thrombectomyBP targetsBlood pressureProspective observational study of patientsObservational study of patientsModified Rankin Scale scoreIschemic strokeAssociated with early neurological deteriorationSymptomatic intracranial hemorrhageClinical end pointsRankin Scale scoreStudy of patientsBrain injuryUpper limit of autoregulationBlood pressure targetsOptimal blood pressureEarly neurological deteriorationPatient limitationsAcute ischemic strokeNet water uptake
Clinical Trials
Current Trials
POST-ICECAP
IRB ID2000037534RoleSub InvestigatorPrimary Completion Date06/01/2028Recruiting ParticipantsBrain Oxygen Optimization in Severe TBI, Phase 3 (BOOST3)
IRB ID2000024956RoleSub InvestigatorPrimary Completion Date07/01/2023Recruiting ParticipantsGenderBothAge14+ yearsAnticoagulation for Stroke Prevention and Recovery After ICH (ASPIRE)
IRB ID2000026409RoleSub InvestigatorPrimary Completion Date04/30/2028Recruiting ParticipantsGenderBothAge18+ years
Academic Achievements & Community Involvement
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Activities
activity BMC Neurology
2020 - PresentJournal ServiceRevieweractivity Hypertension
2020 - PresentJournal ServiceRevieweractivity Neurohospitalst
2020 - PresentJournal ServiceRevieweractivity Neurocritical Care
2021 - PresentJournal ServiceRevieweractivity Journal of the American Heart Association
2020 - PresentJournal ServiceReviewer
Honors
honor American Neurological Association Emerging Scholar Award candidate
09/13/2024National AwardAmerican Neurological AssociationDetailsUnited Stateshonor American Neurologic Association Annual Meeting travel grant
10/22/2022National AwardAmerican Neurological Associationhonor American Neurological Association Emerging Scholar Award candidate
10/22/2022National AwardAmerican Neurological Associationhonor Neurocritical Care Society travel grant
09/22/2020International AwardNeurocritical Care SocietyDetailsUnited Stateshonor AOA Honor Medical Society member
08/01/2015National AwardDetailsUnited States
Clinical Care
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Overview
Jessica Magid-Bernstein, MD, PhD, completed her MD and PhD with a focus in immunology at Rutgers University – New Jersey Medical School in Newark, NJ, in 2015. She then went on to complete her medical internship and residency training in Neurology at New York Presbyterian – Columbia University Medical Center, followed by a fellowship in Neurocritical Care at New York Presbyterian – Columbia University Medical Center & Weill Cornell Medicine before joining the Yale Department of Neurology Division of Neurocritical Care and Emergency Neurology in 2021.
Dr. Magid-Bernstein is dedicated to taking care of complex neurocritically ill patients during her clinical time in the NeuroICU at Yale. When she is not on clinical service, she is developing a research career focused on understanding the role that inflammation plays in outcomes following intracerebral hemorrhage and subarachnoid hemorrhage.
Clinical Specialties
Neurology; Neurocritical Care
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Locations
Yale Neurology
Academic Office
100 York Street, Ste Suite 1N
New Haven, CT 06511
Patient Care Locations
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