Jean Gabriel Charchaflieh, MD, MPH, DrPH
Associate Professor of AnesthesiologyCards
About
Research
Publications
2026
Reducing Systematic Overestimation Bias in the Duke Activity Status Index Estimated Peak Oxygen Uptake: A Cross-Sectional Analysis Using Submaximal Cardiopulmonary Exercise Testing
Hollingsworth K, Zhao Y, Charchaflieh J, Carr Z. Reducing Systematic Overestimation Bias in the Duke Activity Status Index Estimated Peak Oxygen Uptake: A Cross-Sectional Analysis Using Submaximal Cardiopulmonary Exercise Testing. A&A Practice 2026, 20: e02160. PMID: 41729842, DOI: 10.1213/xaa.0000000000002160.Peer-Reviewed Original ResearchConceptsDuke Activity Status IndexSubmaximal cardiopulmonary exercise testingCardiopulmonary exercise testingPeak oxygen uptakeBody mass indexExercise testEstimated peak oxygen uptakeOxygen uptakeCross-sectional analysisObese IPeak VO2Mass indexStatus indexPrimary predictorVO2Progressive overestimationDukeParticipantsIndexSexResidents, Fellows, and Advanced Practice Providers' Awareness of Clinical Practice Guidelines in Managing Perioperative Obstructive Sleep Apnea: A Multi-Institutional Survey
Bhatt N, Lyons M, Auckley D, Mokhlesi B, Charchaflieh J, Myers J, Yilmaz M, Williams L, Khan M, Card E, Gelfand B, Pilla M, Loftsgard T, Sawyer A, Matura L, Carlucci M, Sahni A, Glaser K, Al Ghussain D, Brock G, Magalang U, Rosen I, Gali B. Residents, Fellows, and Advanced Practice Providers' Awareness of Clinical Practice Guidelines in Managing Perioperative Obstructive Sleep Apnea: A Multi-Institutional Survey. Sleep Medicine 2026, 138: 108177. DOI: 10.1016/j.sleep.2025.108177.Peer-Reviewed Original ResearchDoes a Research Paper Always Need a Hypothesis?
Charchaflieh J, Tung A. Does a Research Paper Always Need a Hypothesis? Anesthesia & Analgesia 2026 PMID: 41529670, DOI: 10.1213/ane.0000000000007932.Peer-Reviewed Original Research
2025
Ethical Considerations in Quality Improvement Research versus Human Subject Research.
Vilella A, Stocking J, Tanios M, Bouajram R, Charchaflieh J. Ethical Considerations in Quality Improvement Research versus Human Subject Research. Anesthesia & Analgesia 2025 PMID: 41460727, DOI: 10.1213/ane.0000000000007900.Peer-Reviewed Original ResearchSafe airway management in a patient with previous difficult intubations and distrust of the medical system: A case report
Amaya S, Cormier N, Zygart A, Charchaflieh J. Safe airway management in a patient with previous difficult intubations and distrust of the medical system: A case report. JCA Advances 2025, 2: 100175. DOI: 10.1016/j.jcadva.2025.100175.Peer-Reviewed Original ResearchAirway managementSafe airway managementGrade 1 viewCormack-Lehane grade 1 viewInduction of anesthesiaDental crowdingTopical anesthesiaProlonged intubationSri Lankan womenCase reportAirway assessmentClinical decision-makingOropharyngeal injuryCormack-LehaneAirway historyAirway difficultiesIntubationAirwayPatientsShared decision-makingMandibular translationAnesthesiaIndividualized carePost-traumatic stressPatient experiencePhysicians-in-training and advanced practice providers perceptions in managing perioperative obstructive sleep apnea: a multi-institutional survey
Lyons M, Auckley D, Mokhlesi B, Charchaflieh J, Myers J, Yilmaz M, Williams L, Khan M, Card E, Gelfand B, Pilla M, Loftsgard T, Sawyer A, Matura L, Carlucci M, Sahni A, Glaser K, Al Ghussain D, Brock G, Bhatt N, Magalang U, Rosen I, Gali B. Physicians-in-training and advanced practice providers perceptions in managing perioperative obstructive sleep apnea: a multi-institutional survey. Journal Of Clinical Sleep Medicine 2025, 21: 765-773. PMID: 39745490, PMCID: PMC12048335, DOI: 10.5664/jcsm.11528.Peer-Reviewed Original ResearchObstructive sleep apneaAdvanced practice providersPhysicians-in-trainingSleep apneaClinical roleImproved provider educationPerioperative risk assessmentBreslow-Day testPerioperative complicationsCategories of carePerioperative periodElectronic-mail surveyOdds ratioRisk factorsMulti-institutional surveySleep disordersPatientsPerioperative patientsBreslow-DaySignificant differenceSurgical servicesApneaPractice providersProviders' perceptionsMultiple comparisonsPreoperative submaximal cardiopulmonary exercise testing and its association with early postoperative complications
Carr Z, Charchaflieh J, Brenes-Bastos A, He H, Lin H, Jankelovits A, Gu E, Zafar J, Ghali F, Tan W, Heerdt P. Preoperative submaximal cardiopulmonary exercise testing and its association with early postoperative complications. BJA Open 2025, 14: 100407. PMID: 40421445, PMCID: PMC12105740, DOI: 10.1016/j.bjao.2025.100407.Peer-Reviewed Original ResearchLength of staySubmaximal cardiopulmonary exercise testingInstitutional review board approvalPostoperative complication riskReview board approvalDuke Activity Status IndexCardiopulmonary exercise testingIncreased length of stayAdjusted multivariable regression modelsPostoperative complications predictionPulmonary capacitanceOpen-labelPeak oxygen uptakePerioperative surveillancePrimary endpointNoncardiac surgeryPostoperative complicationsSecondary endpointsSingle-centreComplication riskMET assessmentPeak VOBoard approvalMultivariate regression modelMetabolic equivalentsAirway Safety During Mechanical Ventilation: Survey of ICU Clinicians Practices and Perceptions
Tanios M, Stocking J, Charchaflieh J, Miller A, Patel J, Vilella A, Nguyen H, Epstein S, Beltran A, Devlin J. Airway Safety During Mechanical Ventilation: Survey of ICU Clinicians Practices and Perceptions. Critical Care Explorations 2025, 7: e1234. PMID: 40126919, PMCID: PMC11936560, DOI: 10.1097/cce.0000000000001234.Peer-Reviewed Original ResearchConceptsUnplanned extubationAdult ICUsSociety of Critical Care MedicineEvidence-based guidelinesCritical care medicineAirway management practicesPressure injuriesSurvey of membersClinician practiceManagement beliefsSafety practicesCare medicineICU settingRisk factorsManagement practicesPediatric ICUResponsibility assignmentICUSurveyRespondentsPracticeIs There More to POCUS Than the Heart and Lungs in the Parturient-Venous Excess Ultrasound Score?
Munoz-Acuna R, Charchaflieh J, Deshpande R. Is There More to POCUS Than the Heart and Lungs in the Parturient-Venous Excess Ultrasound Score? Obstetric Anesthesia Digest 2025, 45: 19-20. DOI: 10.1097/01.aoa.0001097560.30255.cc.Peer-Reviewed Original ResearchUltrasound scoreVenous excess ultrasound scoreVenous hemodynamic dysfunctionVolume overloadPulmonary edemaCardiac functionHemodynamic dysfunctionEndothelial dysfunctionVenous disordersTailored treatmentCapillary permeabilityMultisystem conditionPreeclampsiaDysfunctionScoresEdemaVExUSPathophysiologyMultisystemImplementation of Brief Submaximal Cardiopulmonary Testing in a High-Volume Presurgical Evaluation Clinic: Feasibility Cohort Study
Carr Z, Agarkov D, Li J, Charchaflieh J, Brenes-Bastos A, Freund J, Zafar J, Schonberger R, Heerdt P. Implementation of Brief Submaximal Cardiopulmonary Testing in a High-Volume Presurgical Evaluation Clinic: Feasibility Cohort Study. JMIR Perioperative Medicine 2025, 8: e65805. PMID: 39773953, PMCID: PMC11888076, DOI: 10.2196/65805.Peer-Reviewed Original ResearchConceptsDuke Activity Status IndexPeak oxygen uptakePeak METsEvaluation clinicParticipant satisfactionOxygen uptakeSubmaximal cardiopulmonary exercise testingFunctional capacity assessmentLow functional capacityCardiopulmonary exercise testingPerceived ExertionMET assessmentStructured surveyCapacity SurveyMedian patient satisfactionProvider-drivenExercise testMean session timePearson correlation coefficientSurvey scoresCardiopulmonary testFunctional capacityPatient satisfactionCohort studyInclusion criteria
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333 Cedar Street, P.O. Box 208051
New Haven, CT 06520-8051
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