Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsJanice Jin Hwang, MD
Assistant Professor AdjunctAbout
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Titles
Assistant Professor Adjunct
Biography
Dr. Hwang is an endocrinologist and Assistant Professor in the Division of Endocrinology at the Yale School of Medicine. She graduated magna cum laude from Princeton University in 2001 with a major in molecular biology followed by Harvard Medical School in 2006. She completed her residency training in Internal Medicine at the Beth Israel Deaconess Medical Center in Boston, MA and also served as a Chief Medical Resident. Dr. Hwang received her fellowship training in Endocrinology and Metabolism at Massachusetts General Hospital and moved to Yale in 2012 to continue her research training with Dr. Robert Sherwin. Her academic interests are at the intersection of metabolism, neuroscience and imaging. Her research focuses on using advanced brain imaging modalities such as functional MRI and magnetic resonance spectroscopy coupled with classic investigative techniques in metabolism to understand the effects of diabetes and obesity on the brain. Her research has been supported by the National Institutes of Health, the Yale Diabetes Research Center, the Endocrine Fellows Foundation, and the American Diabetes Association. She is the recipient of several awards for her research including the Marilyn Fishman Award for Diabetes Research, the Metabolism Junior Investigator award as well as a Yale Center for Clinical Investigation Junior Faculty Scholars Award.
Appointments
Endocrinology
Assistant Professor AdjunctPrimary
Other Departments & Organizations
- All Institutions
- Diabetes Research Center
- Endocrinology
- Internal Medicine
- Obesity Research Working Group
Education & Training
- MHS
- Yale University (2017)
- Research Fellow
- Yale School of Medicine (2014)
- Clinical and Research Fellow
- Massachusetts General Hospital (2012)
- Chief Medical Resident
- Beth Israel Deaconess Medical Center (2011)
- Residency
- Beth Israel Deaconess Medical Center (2009)
- MD
- Harvard Medical School (2006)
- AB
- Princeton University, Molecular Biology (2001)
Research
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Overview
Medical Research Interests
ORCID
0000-0002-8395-5659
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Graeme Mason, PhD
Douglas Rothman, PhD
Elizabeth Sanchez Rangel, MD
Renata Belfort De Aguiar, MD, PhD
Jason Bini, PhD
Ania Jastreboff, MD, PhD
Obesity
Diabetes Mellitus, Type 2
Diabetes Mellitus, Type 1
Neuroimaging
Publications
2026
Impact of obesity on aromatic amino acids and brain glucose during acute hyperglycemia
Matson B, Gunawan F, Rothman D, Mason G, Ilkayeva O, Newgard C, Hwang J. Impact of obesity on aromatic amino acids and brain glucose during acute hyperglycemia. AJP Endocrinology And Metabolism 2026, 330: e346-e355. PMID: 41638639, PMCID: PMC13036701, DOI: 10.1152/ajpendo.00463.2025.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsAcute hyperglycemiaBrain glucose levelsPlasma concentrationsPlasma amino acidsInsulin resistanceGlucose levelsBrain glucoseMass spectrometry-based metabolomicsEarly markersMarkers of insulin resistancePlasma concentrations of aromatic amino acidsHealthy adultsPlasma concentrations of amino acidsPeripheral metabolic changesImpact of obesityAssociated with insulin resistanceEarly insulin resistanceConcentrations of aromatic amino acidsBranched chain amino acidsPlasma glucagon levelsBrain oxidative stressType 2 diabetesChain amino acidsResponse to hyperglycemiaLean controls
2025
Association of Insulin Resistance and Insulin Secretion Indices and Glucose Metrics From Continuous Glucose Monitoring in People With Obesity.
Belfort-DeAguiar R, Yeckel C, Elshafie A, Comarella A, Hwang J. Association of Insulin Resistance and Insulin Secretion Indices and Glucose Metrics From Continuous Glucose Monitoring in People With Obesity. Diabetes Care 2025, 49: 152-160. PMID: 41418028, PMCID: PMC12719714, DOI: 10.2337/dc25-1395.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsBiomarkers of Glycolysis and the Tricarboxylic Acid Cycle in Youth with and without Obesity
Refugjati E, Li Z, Umano G, Galuppo B, Van Name M, Samuels S, Kang G, Barbieri E, Hwang J, Santoro N. Biomarkers of Glycolysis and the Tricarboxylic Acid Cycle in Youth with and without Obesity. Hormone Research In Paediatrics 2025, 1-6. PMID: 41411205, PMCID: PMC12749259, DOI: 10.1159/000548624.Peer-Reviewed Original ResearchAltmetricConceptsProton-density fat fractionPlasma concentrationsMetabolic consequencesInsulin resistancePrevalence of childhood obesityAdipose tissue insulin resistanceTissue insulin resistanceType 2 diabetesDevelopment of insulin resistanceLiver proton-density fat fractionExcess adiposityMetabolomic analysisChildhood obesityLevels of glucoseMetabolic dysregulationObesityPlasma concentrations of lactateCardiovascular diseaseFat fractionTricarboxylic acidConcentrations of lactateGlucose utilizationYoung adultsTricarboxylic acid cycle intermediatesAdiposeMeasurement of brain glucose metabolism in obesity and diabetes
Hwang J, Bini J, Belfort-DeAguiar R. Measurement of brain glucose metabolism in obesity and diabetes. Diabetologia 2025, 68: 1879-1888. PMID: 40711543, PMCID: PMC12361331, DOI: 10.1007/s00125-025-06491-7.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsBrain glucose metabolismNon-invasive neuroimaging techniquesMeasures of brain glucose metabolismGlucose metabolismNeuroimaging techniquesPathological state of diabetesPositron emission tomographyBrain imagingBrainState of diabetesEmission tomographyPathological statesPhysiological manipulationsInsulin levels1727-P: Reduced Aromatic Amino Acid Suppression during Acute Hyperglycemia in Young Adults with Obesity
MATSON B, GUNAWAN F, ROTHMAN D, MASON G, NEWGARD C, HWANG J. 1727-P: Reduced Aromatic Amino Acid Suppression during Acute Hyperglycemia in Young Adults with Obesity. Diabetes 2025, 74 DOI: 10.2337/db25-1727-p.Peer-Reviewed Original ResearchConceptsCentral nervous systemAcute hyperglycemiaLean controlsBrain glucose levelsMass spectrometry-based metabolomic profilingMeasured plasma amino acidsInsulin resistanceGlucose levelsBranched chain amino acidsPlasma amino acidsDevelopment of insulin resistanceAromatic amino acid levelsChain amino acidsAcid suppressionResponse to hyperglycemiaMetabolomic profilesImpaired suppressionHyperglycemic clampObesityInsulin sensitivityHyperglycemiaNervous systemAmino acid changesBrain glucoseHealthy adults358-OR: Acute Fatty Acid Elevation Does Not Alter Brain Glucose Uptake in Humans
MATSON B, CHANG W, PALMIOTTO J, ROTHMAN D, BELFORT DE AGUIAR R, MASON G, HWANG J. 358-OR: Acute Fatty Acid Elevation Does Not Alter Brain Glucose Uptake in Humans. Diabetes 2025, 74 DOI: 10.2337/db25-358-or.Peer-Reviewed Original ResearchConceptsElevation of non-esterified fatty acidsNon-esterified fatty acid levelsHyperglycemic clampBrain glucose uptakeCirculating non-esterified fatty acidsBrain glucoseAcute elevationIntralipid infusionInsulin resistanceIntravenous infusion of salineAbsence of insulin resistanceNon-esterified fatty acidsInduce peripheral insulin resistanceHealthy adultsInfusion of salinePresence of hyperglycemiaGlucose uptakeMeasures of insulin sensitivityPeripheral insulin resistanceHigh-fat dietGlucose infusion rateIntravenous infusionPlasma glucoseLean individualsMRS scans
2024
12241 Association Between Brain Glucose And Circulating Glucagon Levels In Response To Acute Hyperglycemia
Matson B, Gunawan F, Coppoli A, Jiang L, Rangel E, De Aguiar R, Rothman D, Mason G, Hwang J. 12241 Association Between Brain Glucose And Circulating Glucagon Levels In Response To Acute Hyperglycemia. Journal Of The Endocrine Society 2024, 8: bvae163.674. PMCID: PMC11454728, DOI: 10.1210/jendso/bvae163.674.Peer-Reviewed Original ResearchConceptsCentral nervous systemBrain glucose levelsPlasma glucagon levelsHyperglycemic clampType 2 diabetesGlucagon levelsGlucagon secretionGlucose levelsResponse to hyperglycemiaAcute hyperglycemiaOral glucose tolerance testBrain glucose metabolismResponse to central nervous systemPathophysiology of type 2 diabetesResponse to hypoglycemiaBrain glucoseIndices of insulin sensitivityEffect of obesityRegulation of glucagon secretionGlucose tolerance testConsequences of obesityModulating glucagon secretionOvert metabolic abnormalitiesBrain glucose uptakeCirculating glucagon levelsLow‐calorie diet‐induced weight loss is associated with altered brain connectivity and food desire in obesity
Hoang H, Lacadie C, Hwang J, Lam K, Elshafie A, Rosenberg S, Watt C, Sinha R, Constable R, Savoye M, Seo D, Belfort‐DeAguiar R. Low‐calorie diet‐induced weight loss is associated with altered brain connectivity and food desire in obesity. Obesity 2024, 32: 1362-1372. PMID: 38831482, PMCID: PMC11211061, DOI: 10.1002/oby.24046.Peer-Reviewed Original ResearchCitationsAltmetricConceptsFunctional magnetic resonance imagingIntrinsic connectivity distributionDiet-induced weight lossBrain connectivityAssociated with altered brain connectivityLow-calorie dietEating behavior changesShort-term low-calorie dietRight hippocampusTemporal cortexBrain networksWeight lossBrain clustersEffects of diet-induced weight lossGroup differencesFood desireGlucose levelsDiagnosis of type 2 diabetesBehavioral changesMagnetic resonance imagingType 2 diabetesBrainLeptin levelsFood intakeResonance imagingDeficits in brain glucose transport among younger adults with obesity
Gunawan F, Matson B, Coppoli A, Jiang L, Ding Y, Perry R, Sanchez‐Rangel E, DeAguiar R, Behar K, Rothman D, Mason G, Hwang J. Deficits in brain glucose transport among younger adults with obesity. Obesity 2024, 32: 1329-1338. PMID: 38764181, PMCID: PMC11966602, DOI: 10.1002/oby.24034.Peer-Reviewed Original ResearchCitationsAltmetricConceptsBrain glucose transportLean participantsMarkers of insulin resistanceMagnetic resonance spectroscopy scansEffect of obesityAssociated with alterationsLong-term brain functionCerebral glucose metabolic rateGlucose transportGlucose metabolic rateCardiometabolic comorbiditiesBrain energy utilizationPeripheral markersHyperglycemic clampInsulin resistanceObesityBrain glucose uptakeHuman findingsEating behaviorsYounger ageYoung healthy participantsNeurocognitive functionGlucose transport capacityBrain functionNonesterified fatty acids
2022
Pathophysiology and management of hypoglycemia in diabetes
Sanchez‐Rangel E, Deajon‐Jackson J, Hwang JJ. Pathophysiology and management of hypoglycemia in diabetes. Annals Of The New York Academy Of Sciences 2022, 1518: 25-46. PMID: 36202764, DOI: 10.1111/nyas.14904.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsType 1 diabetes mellitusCounter-regulatory hormonal responsesMechanism of hypoglycemiaDuration of diabetesManageable chronic diseaseOptimal glycemic controlManagement of hypoglycemiaTreatment of hypoglycemiaNew insulin formulationsDiscovery of insulinGlycemic controlDiabetes mellitusTherapeutic optionsBrain glucoseChronic diseasesNovel therapiesDiabetes managementHypoglycemiaPharmacologic targetHormonal responsesInsulin formulationsDiabetesPatientsCurrent literatureDelivery devices
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