James A. Giles, MD, PhD
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Assistant Professor of NeurologyDownloadHi-Res Photo
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Assistant Professor of Neurology
Biography
Dr. James Giles is a vascular neurologist at Yale School of Medicine. He completed medical school and a PhD in neuroscience in 2013 at The University of Manchester in the United Kingdom. He moved to the U.S. in 2014 to complete neurology residency, stroke fellowship and further stroke research training at Washington University School of Medicine. He also undertook a clinical research fellowship at Oxford University in 2020.
He moved to Yale in 2022, where he continues to take care of patients with cerebrovascular disease including ischemic and hemorrhagic stroke. His clinical and translational research has been funded by the National Institutes of Health and the American Heart Association.
Last Updated on January 17, 2025.
Appointments
Neurology
Assistant ProfessorPrimary
Other Departments & Organizations
- All Institutions
- Center for Brain & Mind Health
- Janeway Society
- Neurology
- Vascular Neurology
- Yale Medicine
- Yale New Haven Health System
Education & Training
- Fellow
- Oxford University School of Medicine (2020)
- MPHS
- Washington University School of Medicine, Population Health Sciences (2020)
- Fellow
- Washington University School of Medicine (2019)
- Resident
- Washington University School of Medicine (2018)
- Chief Resident
- Washington University School of Medicine (2018)
- MD
- School of Medicine, The University of Manchester, Medicine (2013)
- PhD
- Faculty of Life Sciences, The University of Manchester, Neuroscience (2012)
Research
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Overview
Medical Research Interests
Hemorrhagic Stroke; Ischemic Stroke
ORCID
0000-0002-3197-3062
Research at a Glance
Yale Co-Authors
Frequent collaborators of James A. Giles's published research.
Publications Timeline
A big-picture view of James A. Giles's research output by year.
Research Interests
Research topics James A. Giles is interested in exploring.
Adam de Havenon, MD, MS
Elspeth Hill, MBChB, PhD, MRes, MRCS, MD
Adeel Zubair, MD
Lauren Hachmann Sansing, MD, MS, FAHA, FANA
Charles Matouk, MD
Daniela Brenda Renedo, MD
43Publications
1,290Citations
Ischemic Stroke
Publications
2025
Transcutaneous Auricular Vagus Nerve Stimulation Reduces Inflammatory Biomarkers after Large Vessel Occlusion Stroke: Results of a Prospective Randomized Open-Label Blinded Endpoint Trial
Laurido-Soto O, Tan G, Nielsen S, Huguenard A, Donovan K, Xu I, Giles J, Dhar R, Adeoye O, Lee J, Leuthardt E. Transcutaneous Auricular Vagus Nerve Stimulation Reduces Inflammatory Biomarkers after Large Vessel Occlusion Stroke: Results of a Prospective Randomized Open-Label Blinded Endpoint Trial. Translational Stroke Research 2025, 17: 7. PMID: 41428140, PMCID: PMC12722435, DOI: 10.1007/s12975-025-01405-6.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsAcute ischemic strokeAnterior circulation large vessel occlusionTranscutaneous auricular vagus nerve stimulationAcute ischemic stroke patientsVagus nerve stimulationLarge vessel occlusionAnti-inflammatory effectsAuricular vagus nerve stimulationSafety endpointsInflammatory biomarkersNerve stimulationIL-6Blinded endpoint trialRandomized open-labelIL-6 levelsEffects of transcutaneous auricular vagus nerve stimulationPost Hoc AnalysisOpen-labelPrimary endpointNo significant differenceSham-controlled trialEndpoint trialsSystemic inflammationLVO patientsClinical trialsClot Composition and Ischemic Stroke Etiology: A Contemporary Narrative Review
Kosyakovsky J, Rossitto C, Antonios J, Renedo D, Stapleton C, Sansing L, Navaratnam D, Giles J, Patel A, Matouk C, Sujijantarat N. Clot Composition and Ischemic Stroke Etiology: A Contemporary Narrative Review. Journal Of Clinical Medicine 2025, 14: 6203. PMID: 40943965, PMCID: PMC12429028, DOI: 10.3390/jcm14176203.Peer-Reviewed Original ResearchCitationsConceptsLarge-artery atherosclerosisAcute ischemic strokeStroke etiologyMechanical thrombectomySecondary stroke preventionStandard of careCryptogenic subtypesClot pathologyClinical levelStroke preventionMultiple comorbiditiesHistological featuresStrokeMolecular analysisIschemic strokeClinical objectivesMultiomics sequencingClinical diagnosisEtiologyClearer understandingCharacterizing Stroke Clots Using Single‐Cell Sequencing
Renedo D, Barak T, DeLong J, Acosta J, Sujijantarat N, Koo A, Rivier C, Clocchiatti-Tuozzo S, Huo S, Antonios J, Giles J, Falcone G, Sheth K, Hebert R, Gunel M, Sansing L, Navaratnam D, Matouk C. Characterizing Stroke Clots Using Single‐Cell Sequencing. Journal Of The American Heart Association 2025, 14: ejaha/2025/041738-t. PMID: 40878981, PMCID: PMC12553457, DOI: 10.1161/jaha.125.041738.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMulti-marker analysisGene expressionMulti-marker Analysis of GenoMic AnnotationCell type-specific gene expressionT cellsGenome-wide association studiesGene expression of cellsSingle-cell RNA sequencingPotential biomarkersTIMP1Genes associated with atherosclerosisHLA-DRB1*01Single-cell sequencingExpression of genesUpregulated expression of genesGene expression profilesCarotid atherosclerosisGenome annotationCD8 T cellsUpregulated expressionImmune cell compositionAssociation studiesNatural killer cellsImmune cell populationsLarge vessel occlusion strokeFactors Associated With Stroke Recurrence After Initial Diagnosis of Cervical Artery Dissection
Mandel D, Shu L, Chang C, Jack N, Guerrero C, Henninger N, Muppa J, Affan M, Lodhi O, Heldner M, Antonenko K, Seiffge D, Arnold M, Omran S, Crandall R, Lester E, Mena D, Arauz A, Nehme A, Boulanger M, Touzé E, Sousa J, Sargento-Freitas J, Barata V, Castro-Chaves P, Brito M, Khan M, Mallick D, Rothstein A, Khazaal O, Kaufman J, Engelter S, Traenka C, de Sousa D, Soares M, Rosa S, Zhou L, Gandhi P, Field T, Mancini S, Metanis I, Leker R, Pan K, Dantu V, Baumgartner K, Burton T, von Rennenberg R, Nolte C, Choi R, MacDonald J, Shahripour R, Guo X, Ghannam M, Almajali M, Samaniego E, Sanchez S, Rioux B, Zine-Eddine F, Poppe A, Fonseca A, Baptista M, Cruz D, Romoli M, De Marco G, Longoni M, Keser Z, Griffin K, Kuohn L, Frontera J, Amar J, Giles J, Zedde M, Pascarella R, Grisendi I, Nzwalo H, Liebeskind D, Molaie A, Cavalier A, Kam W, Mac Grory B, Al Kasab S, Anadani M, Kicielinski K, Eltatawy A, Chervak L, Rivas R, Aziz Y, Bakradze E, Tran T, Gisbert M, Requena M, Velez F, Garcia J, Muddasani V, de Havenon A, Vishnu V, Yaddanapudi S, Adams L, Browngoehl A, Ranasinghe T, Dunston R, Lynch Z, Penckofer M, Siegler J, Mayer S, Willey J, Zubair A, Cheng Y, Sharma R, Marto J, Ferreira V, Klein P, Nguyen T, Asad S, Sarwat Z, Balabhadra A, Patel S, Secchi T, Martins S, Mantovani G, Kim Y, Krishnaiah B, Elangovan C, Lingam S, Qureshi A, Fridman S, Alvarado-Bolanos A, Khasiyev F, Linares G, Mannino M, Terruso V, Vassilopoulou S, Tentolouris-Piperas V, Marino M, Wall V, Indraswari F, Jamal S, Liu S, Alvi M, Ali F, Sarvath M, Morsi R, Kass-Hout T, Shi F, Zhang J, Sokhi D, Said J, Mongare N, Simpkins A, Gomez R, Sen S, Ghani M, Elnazeir M, Xiao H, Kala N, Khan F, Stretz C, Mohammadzadeh N, Goldstein E, Furie K, Yaghi S. Factors Associated With Stroke Recurrence After Initial Diagnosis of Cervical Artery Dissection. Stroke 2025, 56: 1413-1421. PMID: 40143807, DOI: 10.1161/strokeaha.124.048215.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCervical artery dissectionCox regressionOcclusive dissectionIschemic strokeArtery dissectionAssociated with subsequent stroke riskDiagnosis of cervical artery dissectionFactors associated with increased riskAssociated with increased risk of ischemic strokeStroke riskTreated with anticoagulationAssociated with increased riskOptimal treatment strategyHistory of ischemic strokeRetrospective observational studyRisk of ischemic strokeBenefits of anticoagulationIschemic stroke riskFactors associated with stroke recurrenceHigh-risk individualsIdentified risk factorsPost Hoc AnalysisCAD subgroupAntiplatelet therapyInitial diagnosis
2024
Stroke Controversies and Debates: Imaging in Intracerebral Hemorrhage
Bower M, Giles J, Sansing L, Carhuapoma J, Woo D. Stroke Controversies and Debates: Imaging in Intracerebral Hemorrhage. Stroke 2024, 55: 2765-2771. PMID: 39355925, PMCID: PMC11536919, DOI: 10.1161/strokeaha.123.043480.Peer-Reviewed Original ResearchAltmetricIntravenous Thrombolysis in Patients With Cervical Artery Dissection
Shu L, Akpokiere F, Mandel D, Field T, Leon Guerrero C, Henninger N, Muppa J, Affan M, Haq Lodhi O, Heldner M, Antonenko K, Seiffge D, Arnold M, Salehi Omran S, Crandall R, Lester E, López-Mena D, Arauz A, Nehme A, Boulanger M, Touzé E, Sousa J, Sargento-Freitas J, Barata V, Castro-Chaves P, Brito M, Khan M, Mallick D, Rothstein A, Khazaal O, Kaufmann J, Engelter S, Traenka C, Aguiar de Sousa D, Soares M, Rosa S, Zhou L, Gandhi P, Mancini S, Metanis I, Leker R, Pan K, Dantu V, Baumgartner K, Burton T, Von Rennenberg R, Nolte C, Choi R, MacDonald J, Bavarsad Shahripour R, Guo X, Ghannam M, Almajali M, Samaniego E, Rioux B, Zine-Eddine F, Poppe A, Fonseca A, Baptista M, Cruz D, Romoli M, De Marco G, Longoni M, Keser Z, Griffin K, Kuohn L, Frontera J, Amar J, Giles J, Zedde M, Pascarella R, Grisendi I, Nzwalo H, Liebeskind D, Molaie A, Cavalier A, Kam W, Mac Grory B, Al Kasab S, Anadani M, Kicielinski K, Eltatawy A, Chervak L, Chulluncuy Rivas R, Aziz Y, Mistry E, Bakradze E, Tran T, Rodrigo-Gisbert M, Requena M, Saleh Velez F, Garcia J, Muddasani V, de Havenon A, Sanchez S, Vishnu V, Yaddanapudi S, Adams L, Browngoehl A, Ranasinghe T, Dunston R, Lynch Z, Penckofer M, Siegler J, Mayer S, Willey J, Zubair A, Cheng Y, Sharma R, Marto J, Krupka D, Klein P, Nguyen T, Asad S, Sarwat Z, Balabhadra A, Patel S, Secchi T, Martins S, Mantovani G, Kim Y, Krishnaiah B, Elangovan C, Lingam S, Qureshi A, Fridman S, Alvarado A, Khasiyev F, Linares G, Mannino M, Terruso V, Tountopoulou A, Tentolouris-Piperas V, Martinez-Marino M, Carrasco Wall V, Indraswari F, El Jamal S, Liu S, Zhou M, Alvi M, Ali F, Sarvath M, Morsi R, Kass-Hout T, Shi F, Zhang J, Sokhi D, Said J, Mongare N, Simpkins A, Gomez R, Sen S, Ghani M, Elnazeir M, Wangqin R, Xiao H, Kala N, Khan F, Stretz C, Mohammadzadeh N, Goldstein E, Furie K, Yaghi S. Intravenous Thrombolysis in Patients With Cervical Artery Dissection. Neurology 2024, 103: e209843. PMID: 39298709, PMCID: PMC11415265, DOI: 10.1212/wnl.0000000000209843.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAcute ischemic stroke symptomsCervical artery dissectionFunctional independenceIntravenous thrombolysisIschemic stroke symptomsStroke symptomsArtery dissectionIncidence of symptomatic intracranial hemorrhageIschemic strokeSymptomatic intracranial hemorrhageSuspected ischemic strokeClass III evidenceMedian ageSymptomatic ICHIntracranial hemorrhageSecondary analysisGuideline recommendationsICH riskIII evidenceFunctional outcomesPatientsThrombolysisCeADYoung adultsDissectionIs Clot Composition Associated With Cause of Stroke? A Systematic Review and Meta‐Analysis
Sujijantarat N, Templeton K, Antonios J, Renedo D, Koo A, Haynes J, Fathima B, Amllay A, Nowicki K, Huttner A, Giles J, Navaratnam D, Sansing L, Hebert R, King J, Matouk C. Is Clot Composition Associated With Cause of Stroke? A Systematic Review and Meta‐Analysis. Stroke Vascular And Interventional Neurology 2024, 4: e001426. PMID: 41583408, PMCID: PMC11864739, DOI: 10.1161/svin.124.001426.Peer-Reviewed Original ResearchCitationsAltmetricConceptsCause of strokeRed blood cellsWhite blood cellsBlood cellsMechanical thrombectomyCardioembolic groupHistological compositionMeta-analysisLow red blood cellQuantity of red blood cellsRandom-effects meta-analysisAcute ischemic strokeEffects meta-analysisEnglish-language articlesMean percentage differenceAdult patientsMEDLINE databaseCochrane LibraryClinical utilityIschemic strokeLanguage articlesPatientsPercentage differenceArteryCellular compositionMulti-Omics Approaches to Discovering Acute Stroke Injury and Recovery Mechanisms
Giles J, Lee J, Dhar R. Multi-Omics Approaches to Discovering Acute Stroke Injury and Recovery Mechanisms. 2024, 547-584. DOI: 10.1007/978-3-031-41777-1_19.Peer-Reviewed Original ResearchCitationsConceptsPromote recoveryMulti-omics approachGlobal burdenResidual disabilityMulti-OmicsConsequences of ischemic injuryAcute strokeAcute stroke injuryArea of stroke researchStroke outcomeFailed clinical trialsAdequate powerReverse translational approachStroke researchEffective therapeuticsClinical trialsIschemic injuryAntithrombotic Treatment for Stroke Prevention in Cervical Artery Dissection: The STOP-CAD Study
Yaghi S, Shu L, Mandel D, Guerrero C, Henninger N, Muppa J, Affan M, Lodhi O, Heldner M, Antonenko K, Seiffge D, Arnold M, Omran S, Crandall R, Lester E, Mena D, Arauz A, Nehme A, Boulanger M, Touze E, Sousa J, Sargento-Freitas J, Barata V, Castro-Chaves P, Brito M, Khan M, Mallick D, Rothstein A, Khazaal O, Kaufmann J, Engelter S, Traenka C, de Sousa D, Soares M, Rosa S, Zhou L, Gandhi P, Field T, Mancini S, Metanis I, Leker R, Pan K, Dantu V, Baumgartner K, Burton T, Von Rennenberg R, Nolte C, Choi R, MacDonald J, Shahripour R, Guo X, Ghannam M, AlMajali M, Samaniego E, Sanchez S, Rioux B, Zine-Eddine F, Poppe A, Fonseca A, Baptista M, Cruz D, Romoli M, De Marco G, Longoni M, Keser Z, Griffin K, Kuohn L, Frontera J, Amar J, Giles J, Zedde M, Pascarella R, Grisendi I, Nzwalo H, Liebeskind D, Molaie A, Cavalier A, Kam W, Mac Grory B, Al Kasab S, Anadani M, Kicielinski K, Eltatawy A, Chervak L, Chulluncuy-Rivas R, Aziz Y, Bakradze E, Tran T, Rodrigo-Gisbert M, Requena M, Velez F, Gracia J, Mudassani V, de Havenon A, Vishnu V, Yaddanapudi S, Adams L, Browngoehl A, Ranasinghe T, Dunston R, Lynch Z, Penckofer M, Siegler J, Mayer S, Willey J, Zubair A, Cheng Y, Sharma R, Marto J, Ferreira V, Klein P, Nguyen T, Asad S, Sarwat Z, Balabhadra A, Patel S, Secchi T, Martins S, Mantovani G, Kim Y, Krishnaiah B, Elangovan C, Lingam S, Quereshi A, Fridman S, Alvarado A, Khasiyev F, Linares G, Mannino M, Terruso V, Vassilopoulou S, Tentolouris V, Martinez-Marino M, Wall V, Indraswari F, Jamal S, Liu S, Alvi M, Ali F, Sarvath M, Morsi R, Kass-Hout T, Shi F, Zhang J, Sokhi D, Said J, Simpkins A, Gomez R, Sen S, Ghani M, Elnazeir M, Xiao H, Kala N, Khan F, Stretz C, Mohammadzadeh N, Goldstein E, Furie K. Antithrombotic Treatment for Stroke Prevention in Cervical Artery Dissection: The STOP-CAD Study. Stroke 2024, 55: 908-918. PMID: 38335240, DOI: 10.1161/strokeaha.123.045731.Peer-Reviewed Original ResearchCitationsAltmetricConceptsCervical artery dissectionInverse probability of treatment weightingIschemic stroke riskIschemic strokeAntiplatelet therapyArtery dissectionCox regressionOcclusive dissectionCervical artery dissection patientsStroke riskProbability of treatment weightingBenefits of anticoagulationOptimal stroke prevention strategyStroke prevention strategiesReducing ischemic stroke riskAnticoagulant therapyAntithrombotic treatmentProspective studyCross-over approachRandomized trialsAnticoagulationCompare outcomesPrevention strategiesTreatment weightingHigh risk
2023
Delayed Diagnosis in Cerebral Venous Thrombosis: Associated Factors and Clinical Outcomes
Bakradze E, Shu L, Henninger N, Prabhakaran S, Siegler J, De Marchis G, Giles J, Dittrich T, Heldner M, Antonenko K, Kam W, Liebeskind D, Simpkins A, Nguyen T, Yaghi S, Liberman A. Delayed Diagnosis in Cerebral Venous Thrombosis: Associated Factors and Clinical Outcomes. Journal Of The American Heart Association 2023, 12: e030421. PMID: 37753785, PMCID: PMC10727263, DOI: 10.1161/jaha.123.030421.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsFactors associated with delayed diagnosisAssociated with diagnostic delayCerebral venous thrombosis diagnosisCerebral venous thrombosisScale scoreRankin Scale scoreModified Rankin Scale scoreSymptom onsetDiagnostic delayNational Institutes of Health Stroke Scale scoreDelayed DiagnosisNational InstitutePrimary study outcomeLogistic regression analysisRetrospective cohort studyStroke Scale scoreVenous thrombosisClinical outcomesDiagnosis of cerebral venous thrombosisCohort studyNeurological symptom onsetSecondary outcomesAssociated with adverse clinical outcomesAssociated FactorsStudy outcomes
Clinical Trials
Current Trials
Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis (CAPTIVA)
IRB ID2000031893RolePrincipal InvestigatorPrimary Completion Date03/07/2028Recruiting ParticipantsGenderBothAge30 years - 80 yearsAnticoagulation for Stroke Prevention and Recovery After ICH (ASPIRE)
IRB ID2000026409RoleSub InvestigatorPrimary Completion Date04/30/2028Recruiting ParticipantsGenderBothAge18+ years
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activity Junior & Early Career Committee, American Neurological Association
07/01/2021 - PresentProfessional OrganizationsMember
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Overview
James A. Giles, MD, PhD, is a vascular neurologist who specializes in the care of patients with cerebrovascular diseases, including ischemic and hemorrhagic strokes.
As an assistant professor at Yale School of Medicine, Dr. Giles's research interests lie in advancing stroke treatment and prevention, with a focus on translating scientific discoveries into clinical practice.
Dr. Giles completed his medical degree and a doctoral degree in neuroscience at The University of Manchester in the United Kingdom. He then completed his neurology residency and stroke fellowship at Washington University School of Medicine and a clinical research fellowship at Oxford University.
Clinical Specialties
Neurology; Stroke
Fact Sheets
Ischemic Stroke
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