Inderjit Singh, MBChB, BMedSci, FRCP, FCCP, MD
Associate Professor TermCards
About
Research
Publications
2026
3D echo derived right ventricular principal surface strain in pulmonary arterial hypertension
Oakland H, Bellumkonda L, Sugeng L, Joseph P, Kundu P, Izzi D, Zalik F, McCabe S, Raza A, Amendola R, Heerdt P, Hunter K, Singh I. 3D echo derived right ventricular principal surface strain in pulmonary arterial hypertension. AJP Heart And Circulatory Physiology 2026, 330: h729-h736. PMID: 41616802, DOI: 10.1152/ajpheart.00923.2025.Peer-Reviewed Original ResearchConceptsPulmonary arterial hypertension patientsPulmonary arterial hypertensionRV systolic functionRight heart catheterizationSystolic functionEchocardiographic representationArterial hypertensionControl patientsOptimal cutoffRight heartNew York Heart Association functional classRight ventricular (RV) functionTricuspid annular plane systolic excursionAnnular plane systolic excursionFunctional classLongitudinal systolic functionThirty-day outcomesSystolic excursionPAH patientsRV functionHeart catheterizationPrognostic valueThirty-dayHemodynamic criteriaRobust markersProximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging
De Man R, Cai Z, Doddaballapur P, Guerrera N, Regan A, Lin L, Schwarz E, Justet A, Abu Hussein N, Di Palo J, Cavinato C, Raredon M, Heerdt P, Singh I, Yan X, Kang M, Bruns D, Lee P, Tellides G, Humphrey J, Kaminski N, Ramachandra A, Manning E. Proximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging. Aging Cell 2026, 25: e70383. PMID: 41589414, PMCID: PMC12836046, DOI: 10.1111/acel.70383.Peer-Reviewed Original ResearchConceptsProximal pulmonary arteriesPulmonary arterySmooth muscle cellsPerivascular macrophagesMouse modelMuscle cellsRight ventricle functionMedial smooth muscle cellsPulmonary arterial stiffeningRight ventricleVentricle functionAssociated with senescenceECM turnoverLung functionArterial stiffeningArteryAdventitial fibroblastsMolecular targetsAge-relatedGeroscience hypothesisLungAgeIntercellular signalingMiceMacrophagesKnowledge Gaps and Controversies on Cardiopulmonary Exercise Testing in the Assessment of Pulmonary Vascular Disease: An Official Statement of the Pulmonary Vascular Research Institute Exercise and Right Ventricular Function Task Force
Waxman A, Babu A, Badagliacca R, Ferreira E, George P, Guazzi M, Howard L, Kim D, Kovacs G, Kubba S, Langleben D, McCabe C, Menezes T, Oliveira R, Orfanos S, Singh I, Systrom D, Tedford R, Vanderpool R, Vizza C, Rischard F. Knowledge Gaps and Controversies on Cardiopulmonary Exercise Testing in the Assessment of Pulmonary Vascular Disease: An Official Statement of the Pulmonary Vascular Research Institute Exercise and Right Ventricular Function Task Force. Pulmonary Circulation 2026, 16: e70240. PMID: 41586300, PMCID: PMC12824459, DOI: 10.1002/pul2.70240.Peer-Reviewed Original ResearchRight heart catheterizationCardiopulmonary exercise testingPulmonary hypertensionExercise testMultidisciplinary task forceExercise right heart catheterizationInvasive cardiopulmonary exercise testingAssessment of pulmonary vascular diseasePulmonary vascular diseaseTherapeutic decision-makingHeart catheterizationAssessment of PHPrognostic markerConsensus recommendationsVascular diseaseFunctional statusDrug mechanismsTask ForceCatheterizationPrognosisHypertensionCardiopulmonaryPathophysiologyPulmonaryReference valuesRelationship of cardiac MRI-derived pulmonary arterial stiffness markers and invasive hemodynamic
Buber I, Heerdt P, Singh I, Phillip J, Sevgican C, Lamy J, Xiang J, Peters D. Relationship of cardiac MRI-derived pulmonary arterial stiffness markers and invasive hemodynamic. The International Journal Of Cardiovascular Imaging 2026, 1-9. PMID: 41484521, DOI: 10.1007/s10554-025-03589-2.Peer-Reviewed Original ResearchRight heart catheterizationPulmonary artery stiffnessPulse wave velocityRelative area changeCardiac magnetic resonancePulmonary hypertensionPost-capillaryRight heart catheterization measurementsDisease severityRight ventricular pressureBiomarkers associated with disease severityMixed venous saturationArterial stiffness markersPH subgroupsHeart catheterizationPH subtypesPulmonary arteryRetrospective studyNoninvasive markerProspective studyImpaired hemodynamicsVenous saturationHemodynamic parametersClinical utilityArterial stiffnessID#: 2211615 RV/LV Blood Pool T2 Ratio as a Predictive Biomarker in Pulmonary Hypertension: Prediction of Hospitalization in Combined Pre- and Postcapillary Patients
Buber I, Singh I, Heerdt P, Huber S, Feher A, Xiang J, Sevgican C, Lamy J, Joseph P, Peters D. ID#: 2211615 RV/LV Blood Pool T2 Ratio as a Predictive Biomarker in Pulmonary Hypertension: Prediction of Hospitalization in Combined Pre- and Postcapillary Patients. Journal Of Cardiovascular Magnetic Resonance 2026, 28: 102145. DOI: 10.1016/j.jocmr.2025.102145.Peer-Reviewed Original ResearchID#: 2211953 Estimating Blood Oxygen Saturation with T2 maps: Evaluation in Pulmonary Hypertension
Peters D, Singh I, Phillip J, Huber S, Xiang J, Lamy J, Sevgican C, Buber I. ID#: 2211953 Estimating Blood Oxygen Saturation with T2 maps: Evaluation in Pulmonary Hypertension. Journal Of Cardiovascular Magnetic Resonance 2026, 28: 102265. DOI: 10.1016/j.jocmr.2025.102265.Peer-Reviewed Original ResearchIndustry Payments and Prescribing Patterns of Pulmonary Hypertension Therapies in the United States
Tarras E, Murayama A, Singh I, Freeman L, Kugo H, Marshall D. Industry Payments and Prescribing Patterns of Pulmonary Hypertension Therapies in the United States. Pulmonary Circulation 2026, 16: e70279. PMID: 41804477, PMCID: PMC12967594, DOI: 10.1002/pul2.70279.Peer-Reviewed Original Research
2025
Impact of an Artificial Intelligence-Guided Pulmonary Embolism Response Team (AIPERT) on Patient Transfers, Diagnosis, and Management: A Healthcare System Experience
Khosla A, Singh I, Pollak J, Mojibian H. Impact of an Artificial Intelligence-Guided Pulmonary Embolism Response Team (AIPERT) on Patient Transfers, Diagnosis, and Management: A Healthcare System Experience. Clinics And Practice 2025, 15: 207. PMID: 41294638, PMCID: PMC12651477, DOI: 10.3390/clinpract15110207.Peer-Reviewed Original ResearchPE response teamsPulmonary embolismArtificial intelligenceYear 2Healthcare system experienceYear 1Clinical decision support systemsMulti-hospital health systemResponse teamTime-sensitive conditionsAI-based clinical decision support systemsRight ventricular (RV) strainHospital lengthPulmonary Embolism Response TeamRapid Risk StratificationVariable clinical presentationAssociated with sustained increasesPulmonary embolism patientsReal world applicationsClinical decision-makingRetrospective observational studyHealth systemDecision support systemInterhospital transferPatient transferFirst-in-US Pilot Study of Aquablation in Ambulatory Surgery Centers: Clinical Outcomes and Economic Feasibility
Marhamati S, Kangotra I, Perez D, Rayan D, Umanzor L, Lavoie J, Gandhi N, Desai P, Lim K, Zorn K, Klein J, Singh I. First-in-US Pilot Study of Aquablation in Ambulatory Surgery Centers: Clinical Outcomes and Economic Feasibility. Urology 2025, 207: 220-224. PMID: 41015303, DOI: 10.1016/j.urology.2025.09.032.Peer-Reviewed Original ResearchConceptsBenign prostatic hyperplasiaLower urinary tract symptomsClinical outcomesAmbulatory surgery centersModerate to severe lower urinary tract symptomsSevere lower urinary tract symptomsSingle-center cohort studySurgery centersClavien-Dindo gradePost-void residualsUrinary tract symptomsAmbulatory surgery center settingAquablation therapyIPSS scoreUroflow parametersClavien-DindoProstatic hyperplasiaComplication rateAquablationTreatment optionsCohort studySymptom scoresBaseline meanReimbursement dataComplicationsRight Ventricular-Pulmonary Arterial Uncoupling Thresholds in Acute Pulmonary Embolism
Zeba F, Singh I, Gomez J, Khosla A. Right Ventricular-Pulmonary Arterial Uncoupling Thresholds in Acute Pulmonary Embolism. Lung 2025, 203: 71. PMID: 40581902, PMCID: PMC12718099, DOI: 10.1007/s00408-025-00826-2.Peer-Reviewed Original ResearchConceptsRV-PA uncouplingTricuspid annular plane systolic excursionPulmonary artery systolic pressureAcute pulmonary embolismAcute PERV-PAPulmonary embolismVA-ECMORatio of tricuspid annular plane systolic excursionTreatment of acute PEDiagnosis of acute PEAnnular plane systolic excursionVeno-arterial extracorporeal membrane oxygenationRetrospective analysis of patientsAssociated with adverse outcomesAssociated with worse outcomesRV/LV ratio >Artery systolic pressureEuropean Society of CardiologyExtracorporeal membrane oxygenationAnalysis of patientsRank-sumKruskal-Wallis rank sumRisk stratification scoresSociety of Cardiology
Academic Achievements & Community Involvement
Clinical Care
Overview
Inderjit Singh, MBChB, (a medical degree awarded in the United Kingdom) is director of the Pulmonary Vascular Disease Program and specializes in treating pulmonary hypertension (high blood pressure in the heart-to-lung system).
Dr. Singh was steered toward medicine at an early age while growing up in Malaysia, where his father was a pediatrician. He often accompanied his father to work and says he enjoyed watching him help others feel better.
During medical school, he was drawn to pulmonary medicine, within which he discovered pulmonary vascular medicine—and pulmonary hypertension in particular.
“I have a strong interest in understanding the right heart and how it interacts with the pulmonary circulation,” Dr. Singh says. “And I like how pulmonary hypertension overlaps with so many specialties from cardiology to rheumatology to hepatology. You need to know all the different organs and disease processes to understand pulmonary hypertension.”
Pulmonary hypertension is also an exciting field because of many advancements in treatment, he says. “For a long time, we didn’t have much to offer in terms of therapy. But now there is more understanding of the disease, so much so that now you have dedicated training programs for pulmonary hypertension,” he says.
For research, Dr. Singh explores how the right ventricle of the heart and the pulmonary circulation interact, particularly during exercise.
“Our research is mainly focused on how the right heart interacts with the lungs’ blood vessels at rest and during exercise,” he explains. “We are one of the few centers in the world that performs invasive cardiopulmonary exercise test (iCPET). We primarily perform iCPET for patients who have unexplained shortness of breath or fatigue. So, these are patients who've had all the routine investigative testing, all of which do not explain their symptoms.”
Clinical Specialties
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Pulmonary Hypertension
Learn More on Yale MedicinePulmonary Embolism
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Yale Medicine News
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News
- November 05, 2024
Yale Researchers at American Heart Association Scientific Session 2024
- July 24, 2024
Yale Department of Internal Medicine Faculty Promotions and Appointments (July 2024)
- April 27, 2023
Study Uncovers Reduced Exercise Tolerance and Other Changes in Long COVID
- February 21, 2022
Despite Recovering from COVID-19, Shortness of Breath Persists
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Pulmonary Vascular Disease Program
15 York Street, Lippard Laboratory for Clinical Investigation
NEW HAVEN, CT 06519
United States
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