2025
A novel prognostic framework for HBV-infected hepatocellular carcinoma: insights from ferroptosis and iron metabolism proteomics
Cheng Z, Ren Y, Wang X, Zhang Y, Hua Y, Zhao H, Lu H. A novel prognostic framework for HBV-infected hepatocellular carcinoma: insights from ferroptosis and iron metabolism proteomics. Briefings In Bioinformatics 2025, 26: bbaf216. PMID: 40381315, PMCID: PMC12085197, DOI: 10.1093/bib/bbaf216.Peer-Reviewed Original ResearchConceptsHepatocellular carcinoma patientsHepatocellular carcinomaHCC patientsPrognostic modelAdverse prognosisClinically relevant risk groupsRisk groupsTreatment of hepatocellular carcinomaTumor immune microenvironmentAlpha-fetoprotein levelsHigh-risk HCC patientsRelevant risk groupsPrognosis of HCC patientsHBV-infected hepatocellular carcinomaIron metabolismOverall survivalDifferential expression patternsDistant metastasisImmune microenvironmentTumor sizeLiver cancer progressionTumor differentiationMicrovascular invasionPredictive nomogramValidation cohort
2023
HBV-infected hepatocellular carcinoma can be robustly classified into three clinically relevant subgroups by a novel analytical protocol
Cheng Z, Li L, Zhang Y, Ren Y, Gu J, Wang X, Zhao H, Lu H. HBV-infected hepatocellular carcinoma can be robustly classified into three clinically relevant subgroups by a novel analytical protocol. Briefings In Bioinformatics 2023, 24: bbac601. PMID: 36736372, DOI: 10.1093/bib/bbac601.Peer-Reviewed Original ResearchMeSH Keywordsalpha-FetoproteinsCarcinoma, HepatocellularHepatitis BHepatitis B virusHumansLiver NeoplasmsTumor MicroenvironmentConceptsHepatocellular carcinomaClinical stageImmune microenvironmentTumor sizeHepatitis B virus infectionLow alpha-fetoprotein levelsMetabolism-related proteinsRelevant subgroupsB virus infectionSevere liver dysfunctionGood liver functionHigh AFP levelsAlpha-fetoprotein levelsPrimary liver malignancySmaller tumor sizeLarger tumor sizeLower clinical stageHigher clinical stageCancer-related deathProliferation activityPrevention of HBVNear-normal levelsLow proliferation activityLiver dysfunctionHigh proliferation activity
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