2025
Hypermethylation of PM20D1 Is Associated With Carotid Bifurcation Intima‐Media Thickness in Dominican Republic Families
Dueker N, Zhao H, Gardener H, Kaur S, Dong C, Cabral D, Sacco R, Blanton S, Rundek T, Wang L. Hypermethylation of PM20D1 Is Associated With Carotid Bifurcation Intima‐Media Thickness in Dominican Republic Families. Journal Of The American Heart Association 2025, 14: e034033. PMID: 39791430, PMCID: PMC12054445, DOI: 10.1161/jaha.123.034033.Peer-Reviewed Original ResearchConceptsDifferentially Methylated RegionsMendelian randomization analysisCytosine nucleotidesCarotid intima-media thicknessExpression quantitative trait loci studiesRandomization analysisExpression quantitative trait lociIntima-media thicknessQuantitative trait loci studiesEpigenome-wide association studiesQuantitative trait lociTraditional vascular risk factorsBifurcation intima-media thicknessBlood-derived DNAGuanine nucleotide siteLinear mixed model analysisNucleotide sitesVascular risk factorsMeasures of atherosclerosisCarotid bifurcation intima-media thicknessTrait lociAssociation studiesNucleotide methylationLoci studiesGenetic variants
2021
Interactions Between Enhanced Polygenic Risk Scores and Lifestyle for Cardiovascular Disease, Diabetes, and Lipid Levels
Ye Y, Chen X, Han J, Jiang W, Natarajan P, Zhao H. Interactions Between Enhanced Polygenic Risk Scores and Lifestyle for Cardiovascular Disease, Diabetes, and Lipid Levels. Circulation Genomic And Precision Medicine 2021, 14: e003128. PMID: 33433237, PMCID: PMC7887077, DOI: 10.1161/circgen.120.003128.Peer-Reviewed Original ResearchConceptsType 2 diabetesAbsolute risk reductionPolygenic risk scoresLifestyle adherenceCardiovascular diseaseGenetic riskRisk scoreCoronary artery diseaseBody mass indexGreater absolute benefitHigher polygenic risk scoreHigh genetic riskAdditive interactionRisk reductionArtery diseaseLDL cholesterolTotal cholesterolAtrial fibrillationMass indexAbsolute benefitTriglyceride levelsRisk factorsLipid levelsPhysical activityLifestyle status
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