Leveraging local ancestry and cross-ancestry genetic architecture to improve genetic prediction of complex traits in admixed populations
Zhou G, Yolou I, Xie Y, Zhao H. Leveraging local ancestry and cross-ancestry genetic architecture to improve genetic prediction of complex traits in admixed populations. American Journal Of Human Genetics 2025, 112: 1923-1935. PMID: 40633541, PMCID: PMC12252582, DOI: 10.1016/j.ajhg.2025.06.010.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresAdmixed individualsNon-European populationsLocal ancestryTransferability of PRSPerformance of polygenic risk scoresAdmixed populationsCross-ancestryPolygenic risk score calculatorGenetic prediction of complex traitsGenetic predictionEffect sizePrediction of complex traitsPopulation ArchitectureUK BiobankPolygenic predictionAdmixed AmericansAncestry clustersGenetic architectureComplex traitsPRS modelRisk scoreGenetic variantsAncestryIndividuals
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