2025
Unraveling the genetics of gulf war illness in diverse participants enrolled in the million veteran program
Pathak G, Koller D, Cabrera-Mendoza B, Nono Djotsa A, Wendt F, De Lillo A, Friligkou E, He J, Kouakou M, Duong L, Vahey J, Steele L, Quaden R, Harrington K, Ahmed S, Gaziano J, Concato J, Zhao H, Radhakrishnan K, Gelernter J, Gifford E, Aslan M, Helmer D, Hauser E, Polimanti R. Unraveling the genetics of gulf war illness in diverse participants enrolled in the million veteran program. Human Molecular Genetics 2025, ddaf075. PMID: 40366759, DOI: 10.1093/hmg/ddaf075.Peer-Reviewed Original ResearchPolygenic scoresGulf War IllnessGenome-wide dataDepression polygenic scoresPhenome-wide analysisDiverse ancestral backgroundsT2D polygenic scoreAssociated with higher oddsGulf War eraPolygenic architectureAncestral backgroundVeteran ProgramChronic conditionsHigher oddsType 2 diabetesGW veteransVeteransDisease pathogenesisDiverse participantsGulf WarOddsPhysical strengthIllnessComprehensive assessmentAnxiety
2021
Interactions Between Enhanced Polygenic Risk Scores and Lifestyle for Cardiovascular Disease, Diabetes, and Lipid Levels
Ye Y, Chen X, Han J, Jiang W, Natarajan P, Zhao H. Interactions Between Enhanced Polygenic Risk Scores and Lifestyle for Cardiovascular Disease, Diabetes, and Lipid Levels. Circulation Genomic And Precision Medicine 2021, 14: e003128. PMID: 33433237, PMCID: PMC7887077, DOI: 10.1161/circgen.120.003128.Peer-Reviewed Original ResearchConceptsType 2 diabetesAbsolute risk reductionPolygenic risk scoresLifestyle adherenceCardiovascular diseaseGenetic riskRisk scoreCoronary artery diseaseBody mass indexGreater absolute benefitHigher polygenic risk scoreHigh genetic riskAdditive interactionRisk reductionArtery diseaseLDL cholesterolTotal cholesterolAtrial fibrillationMass indexAbsolute benefitTriglyceride levelsRisk factorsLipid levelsPhysical activityLifestyle status
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