Gary Soffer, MD, FAAP
Associate Professor of Pediatrics (Pulmonary, Allergy, Immunology and Sleep Medicine)Cards
About
Research
Publications
2026
Shared Decision Making and Integrative Medicine in the Allergist’s Office
Soffer G, Marshall G. Shared Decision Making and Integrative Medicine in the Allergist’s Office. Annals Of Allergy Asthma & Immunology 2026 PMID: 41802596, DOI: 10.1016/j.anai.2026.03.002.Peer-Reviewed Original ResearchImproving Use of Oral Antihistamines in a Children's Hospital.
Wong K, Criscione J, Tepler E, Mehta M, Powers E, Featherly J, Tiyyagura G, Goldman M, Grossman M, Soffer G. Improving Use of Oral Antihistamines in a Children's Hospital. 2026, 157 PMID: 41667068, DOI: 10.1542/peds.2025-072208.Peer-Reviewed Original ResearchConceptsPediatric emergency departmentEmergency department revisitsInpatient unitLength of stayProportion of patientsFirst-generation antihistaminesMultidisciplinary quality improvement initiativeSecond-generation antihistaminesMedian inpatient length of stayQuality improvement initiativesInpatient length of stayStatistical process control chartsProcess control chartsEducation sessionsImplement interventionsKnowledge scoresImprovement initiativesInpatient settingClinician educationEmergency departmentOutcome measuresProcess measuresBalance measurementsKnowledge assessmentCetirizine use
2025
Corrigendum: “Decreased T helper 1 cell function underlies recurrent sinopulmonary infections in the 17q12 deletion syndrome” EBioMedicine, 2025, Feb:112:105578
Shin J, Shin H, Gutierrez A, Yoo N, Par-Young J, Osmani L, Shin M, Sanchez-Lara P, Bucala R, Soffer G, Kang I. Corrigendum: “Decreased T helper 1 cell function underlies recurrent sinopulmonary infections in the 17q12 deletion syndrome” EBioMedicine, 2025, Feb:112:105578. EBioMedicine 2025, 123: 106095. PMID: 41447758, PMCID: PMC12799761, DOI: 10.1016/j.ebiom.2025.106095.Peer-Reviewed Original ResearchAssociation of clinical manifestations and immune alterations with genetic variants of uncertain significance in patients concerned for inborn errors of immunity
Novotny S, Yoo N, Chen J, Granoth M, Kohli-Pamnani A, Hsu F, Rodenas M, Steele R, Kaman K, Soffer G, Price C, Kuster J, Kang I, Osmani L, Shin J. Association of clinical manifestations and immune alterations with genetic variants of uncertain significance in patients concerned for inborn errors of immunity. Clinical Immunology 2025, 277: 110513. PMID: 40354868, DOI: 10.1016/j.clim.2025.110513.Peer-Reviewed Original ResearchInborn errors of immunityErrors of immunityGenetic variantsInborn errorsAssociation of clinical manifestationsGene clusterGene functionStudy evaluated associationsImmune alterationsDiagnostic challengeClinical manifestationsImmunological profileGenetic testingVUSGenesImmunological characteristicsImmune functionLaboratory dataImmunityVariantsAssociationPatientsUpdate on the utilization of complementary therapies by adolescents with asthma in an urban population
Soffer G, Feinberg T, Kroll H, Reznik M. Update on the utilization of complementary therapies by adolescents with asthma in an urban population. Journal Of Asthma 2025, 62: 1304-1312. PMID: 40040497, DOI: 10.1080/02770903.2025.2475451.Peer-Reviewed Original ResearchAsthma Control TestCAM useUtilization of complementary therapiesPrevalence of CAM usePrescription adherenceEfficacy of CAMHealth-promoting behaviorsPrimary care clinicsElectronic health recordsCAM utilizationCare clinicsActivity prescriptionHealth recordsAlternative medicineComplementary therapyAsthma managementLack of associationOutpatient specialtyAsthma controlSelf-ReportAsthma severityLogistic regressionMind-BodyUrban adolescentsDemographic informationDecreased T helper 1 cell function underlies recurrent sinopulmonary infections in the 17q12 deletion syndrome
Shin J, Shin H, Gutierrez A, Yoo N, Par-Young J, Osmani L, Shin M, Sanchez-Lara P, Bucala R, Soffer G, Kang I. Decreased T helper 1 cell function underlies recurrent sinopulmonary infections in the 17q12 deletion syndrome. EBioMedicine 2025, 112: 105578. PMID: 39891996, PMCID: PMC11840234, DOI: 10.1016/j.ebiom.2025.105578.Peer-Reviewed Original ResearchConceptsCD4+ T cellsRecurrent sinopulmonary infectionsT cell functionRNA-seq analysisT cellsHealthy controlsSinopulmonary infectionsRNA-seqT-betIFN-gFrequency of CD4+ T cellsCD4+ T cell functionTh1 transcription factor T-betDeletion syndromeFlow cytometryCompared to age-matched healthy controlsTranscription factor T-betDecreased T-betUrinary tract abnormalitiesAge-matched healthy controlsMultiplex assayDownstream effector cytokinesEffector cytokinesRecurrent infectionsTh17 cytokinesAlternative, complementary, and integrative medicine approaches to allergic rhinitis
Soffer G, Myers C, Weinstock M, Hand M. Alternative, complementary, and integrative medicine approaches to allergic rhinitis. Annals Of Allergy Asthma & Immunology 2025, 135: 5-6. PMID: 39870210, DOI: 10.1016/j.anai.2025.01.021.Peer-Reviewed Original Research
2024
OPTIMIZING APPROPRIATE SELECTION OF ORAL ANTIHISTAMINES IN PEDIATRIC INPATIENT SETTING: A QUALITY IMPROVEMENT INITIATIVE
Wong K, Criscione J, Featherly J, Powers E, Grossman M, Soffer G. OPTIMIZING APPROPRIATE SELECTION OF ORAL ANTIHISTAMINES IN PEDIATRIC INPATIENT SETTING: A QUALITY IMPROVEMENT INITIATIVE. Annals Of Allergy Asthma & Immunology 2024, 133: s88. DOI: 10.1016/j.anai.2024.08.284.Peer-Reviewed Original ResearchPediatric inpatient settingInpatient settingQuality improvement initiativesQuality improvement projectPost-intervention assessmentOnset of actionPediatric inpatient unitsOral antihistaminesAntihistamine useEducation sessionsPost-interventionHospital medicineImprovement initiativesInpatient unitClinical pathwayImprovement projectConclusion EducationMultidisciplinary teamOral antihistamine useFirst-line treatmentSide effect profilePercentage of patientsSecond-generation antihistaminesFirst-generation antihistaminesProvidersConcordance of provider chart notation and guideline-based classification of asthma severity
Kroll H, Feinberg T, Soffer G, Reznik M. Concordance of provider chart notation and guideline-based classification of asthma severity. Journal Of Asthma 2024, 61: 1402-1411. PMID: 38717912, DOI: 10.1080/02770903.2024.2353106.Peer-Reviewed Original ResearchAsthma severity classificationChart notationUrban primary careClassification of asthma severityFair-to-goodWeighted kappa coefficientGuideline-based criteriaPrimary careNAEPP guidelinesDiagnosed asthmaConvenience sampleGuideline-basedAsthma criteriaPositive predictive valueAsthma severityAssess concordanceGuideline classificationPhysiciansEvaluate concordanceSeverity classificationClinic patientsPrescribed treatmentNAEPPMcNemar testKappa coefficientAppropriate Selection of Antihistamines in the Management of Allergic Reactions in the Pediatric Emergency Room: a quality improvement initiative
Tepler E, Mehta M, Tiyyagura G, Goldman M, Powers E, Soffer G. Appropriate Selection of Antihistamines in the Management of Allergic Reactions in the Pediatric Emergency Room: a quality improvement initiative. The Journal Of Allergy And Clinical Immunology 2024, 153: ab54. DOI: 10.1016/j.jaci.2023.11.192.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
Clinical Care
Overview
Gary Soffer, MD, is an allergist-immunologist who treats food and environmental allergies, asthma, hay fever, and eczema in children and adults.
Within the Integrative Medicine program at Smilow Cancer Hospital, Dr. Soffer provides cancer patients and survivors complementary therapies that complement, but do not replace, their standard cancer treatments. The program offers mind-body interventions, massage, and guidance on the safe use of herbal and dietary supplements.
“Allergy and integrative medicine are both areas that require the doctor to look at the whole patient and not just a single organ or disease,” he says. “My specialties allow me to get to know my patients and build long-lasting relationships.”
Any diagnosis can be difficult to navigate, he says. “I love working with my patients and their families to help guide them along their health journey.”
“My favorite part of the job is being with my amazing patients,” he says. “Whether this is seeing kids with food allergies, or adults with cancer, each patient has contributed to my life in a meaningful way.”
Clinical Specialties
Pediatric Allergy & Immunology
Fact Sheets
Penicillin Allergy
Learn More on Yale MedicineSeasonal Allergies (Allergic Rhinitis)
Learn More on Yale MedicineAlpha-gal Syndrome (AGS)
Learn More on Yale MedicineColds: How to Prevent Them
Learn More on Yale Medicine
Board Certifications
Allergy & Immunology
- Certification Organization
- AB of Allergy & Immunology
- Original Certification Date
- 2018
Yale Medicine News
News & Links
News
- February 13, 2026Source: Verywell Health
How Long Does Vitamin C Stay in Your Body?
- January 06, 2026Source: Don't Feed the Fear: Allergy Anxiety & Trauma
Rethinking Health in the New Year: Dr. Gary Soffer on Integrative Medicine
- September 11, 2025
Finding Patterns in Genetic Uncertainty: Clues for Inborn Errors of Immunity
- December 09, 2024Source: Healio
Meditation practice may positively influence allergy, immunology symptoms
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