Francis Lee, MD, PhD, FAAOS, MBA

1. Affiliation: Professor with Tenure, Unmodified Title; Wayne O. Southwick Professor; Orthopedic Surgeon and Scientist, Department of Orthopedic Surgery, School of Medicine, Yale University (2016-Present); Professor in Pathology, Secondary Appointment, Yale University (2017-Present); Professor in Biomedical Engineering, Secondary Appointment (2019-Present); Professor, Graduate School of Art and Science, Yale University (2019-Present); Professor with Tenure and Robert Carroll & Jane Chace Carroll Professor, Columbia University, New York (2012-2016); Orthopaedic Attending & Chief of Orthopaedic Oncology, New York Presbyterian Hospital, Columbia University Medical Center, New York (1999-2016)
2. Clinical Practice Locations: Greenwich Hospital, Stamford Office, and Yale New Haven Hospital System
3. Clinical Expertise: Sarcomas, Complex Musculoskeletal Reconstruction in Adults and Children; Musculoskeletal Bone and Soft Tissue Tumors (Benign Tumors and Cancers) & Complex Limb Reconstruction in Adults and Children; Pathological Fractures, Minimally Invasive Surgery for Metastatic Cancers to Bone (Breast, Prostate, Thyroid and Others); Failed Knee & Hip Implants; Osteomyelitis; Pediatric Orthopedics; Osteoid Osteoma, Enchondroma, Osteochondroma, Metabolic and Genetic Bone Diseases, Spine Tumors
4. Research Interest: NIH R01-funded research programs in metastatic cancer-induced bone loss, fracture healing, regenerative orthopedics, and bone infection. Our lab is located in Tompkin 5 Orthopedic Research Laboratories.
5. Administration: Vice Chair of Academic, Scientific, and Research Affairs (2016-2018; 2020-2023); Yale School of Medicine Admissions Committee; Yale University Saybrook College Advisor
6. Education: American Board of Orthopaedic Surgery Written Question Task Force, Orthopaedic Research Society Mentorship Committee, New York Orthopaedic Pathology Review Course
7. External Activities: NIH Skeletal Biology, Structure, and Regeneration (SBSR) Study Section Chair (2018-2020); Musculoskeletal Tumor Society Research Committee Chair (2017-2020); American Academy of Orthopaedic Surgeons Research Development Committee Chair (2019-2022); Orthopaedic Research and Education Foundation (OREF) Research Grant Committee Vice Chair (2019-2020); OREF Research Grant Chair & OREF Board of Directors; Board of Trustees (2020-2023)
8. Musculoskeletal Tumor Society (MSTS) Presidential Line (2022-2023 Treasurer; 2023- 2024: Secretary; 2024-2025 President-Elect; 2025-2026 President); International Society of Limb Salvage (ISOLS) Board Member 2024-Present

9. Research Programs and Major Research Grants

- NIH/NIAMS R01 AR081656-A1 (2024-202: PI: Francis Y. Lee, M.D.): Rescuing Impaired Fracture Healing by Molecular Targeting

- NIH/NIAMS R01 AR 073607 (2019-2024; PI: Francis Y. Lee, M.D.): PTH to rescue impaired fracture healing.

- NIH/NIAMS R01 (2015-2023; PI: Francis Y. Lee, M.D.): Infection and bone destruction; Eradication of bone destruction

- NIH/NCI R01 (2015-2022; PI: Francis Y. Lee, M.D.): Interactions between metastatic cancers and bone; Bone loss

- NIH/NIAMS R01 (2009-2019; PI: Francis Y. Lee, M.D.): Inflammation and bone loss; Osteoclastogenesis

- NIH/NIBIB R01 (Completed; 2007-2018; PI: Francis Y. Lee, M.D.): Biomaterials interface biology

- Musculoskeletal Transplantation Foundation (2013-2018): Enhanced Allograft Incorporation with Growth Factors

- NIAMS Mentored K08 Award (2017-2022; Mentor for PI Dr. David Koveacevic): Shoulder Inflammation

- Department of Defense (Completed; 2010-2015; PI: Francis Y. Lee, M.D.): 3D printed scaffolds for bone and cartilage defects

• External Scholarly Activities: Musculoskeletal Tumor Society Executive Committee member and Research Committee Chair (2017-2020); National Institute of Health Skeletal Biology, Structure and Regeneration(SBSR) Study Section Permanent Member (2015-2020) and Study Section Chair (2018-2020); Musculoskeletal Tumor Society (MSTS) Research Committee Chair (2018-2020); AAOS Tumor Program Committee (2016-2019); AAOS Research Development Committee Chair (2019-2022); Orthopaedic Research and Education Foundation (OREF) Research Grant Committee Vice Chair (2018-2020); Orthopaedic Research Society/International Society for Fracture Repair (ISFR) Board Member (2019-2021); Orthopaedic Research and Education Foundation (OREF) Research Grant Committee Chair (2020-Present); American Bone and Joint Surgery Member (2020-Present); AAOS Kappa Delta Award & OREF Clinical Research Award Selection Task Force Co-Chair
• Interactions with Undergraduate Students, YSM Medical Students, M.D.-Thesis Medical Students, M.D.-Ph.D. Candidate, Graduate Students, and Post-doctoral Fellows: Please send inquiries to francis.lee@yale.edu for research and clinical opportunities. Summer Research Fellow and One-Year YSM-sponsored Fellowships are provided.
• Mentoring and Supporting Junior Faculty, Fellows, and Residents: Assisting Career Development Awards or Grants. Academic Promotion Guidance; Primary Mentorship for NIAMS K08 Career Development Award for an Orthopaedic Surgeon at Yale Orthopaedics & Rehabilitation (2017-2022); Mentorship for OREF Residents & Faculty Award
• Yale University (2016 - Present): Yale University Saybrook College Fellow; Medical School Admissions Committee; Biological and Biomedical Science Program; Faculty, Yale university Art and Science Graduate School
• Columbia University, New York, and New York Presbyterian Hospital (1999 - 2016): Professor of Orthopaedic Surgery with Tenure (2012-2016), Robert Carroll and Jane Chace Carroll Professor (2014-2016), Associate Professor with Tenure (2009-2012), Associate Professor (2005-2009), Assistant Professor (1999-2005); Orthopedic Surgeon, New York Presbyterian Hospital, New York; Columbia University Senate Budget Review Committee (2011-2015)