Fatir Qureshi, PhD
Associate Research ScientistCards
About
Research
Publications
2025
Transcriptional and epigenetic targets of MEF2C in human microglia contribute to cellular functions related to autism risk and age-related disease
Nguyen C, Broersma E, Warden A, Mora C, Han C, Keulen Z, Spann N, Wang J, Ramirez G, Mak S, Trescott S, Khakpour M, Johnson A, Qureshi F, La Frano M, Mohajeri K, Talkowski M, Corradin O, Tremblay M, Glass C, Coufal N. Transcriptional and epigenetic targets of MEF2C in human microglia contribute to cellular functions related to autism risk and age-related disease. Nature Immunology 2025, 26: 1989-2003. PMID: 41125877, PMCID: PMC12571900, DOI: 10.1038/s41590-025-02299-0.Peer-Reviewed Original ResearchConceptsGenome-wide profilingDisease-associated functionsEpigenetic targetsLoss of Mef2cHuman microgliaNervous system developmentTranscriptional functionFunction of MEF2CTranscription factorsCellular functionsEpigenetic approachesAge-related diseasesLipid accumulationStem cell linesFunctional analysisRegulatory landscapeLysosomal dysfunctionCell linesPluripotent stem cell linesHyperinflammatory phenotypeMouse xenotransplantation modelMEF2CMicroglia in vivoMEF2C haploinsufficiencyDevelopment of neurological diseasesMultiple hypothesis testing for pre-screening of factor selection for classification of high-dimensional data
Arici H, Qureshi F, Mulmule J, Hahn J. Multiple hypothesis testing for pre-screening of factor selection for classification of high-dimensional data. Journal Of Process Control 2025, 152: 103469. DOI: 10.1016/j.jprocont.2025.103469.Peer-Reviewed Original Research
2024
Bimodal distribution of intestinal Candida in children with autism and its potential link with worse ASD symptoms
Nirmalkar K, Patel J, Kang D, Bellinghiere A, Bowes D, Qureshi F, Adams J, Krajmalnik-Brown R. Bimodal distribution of intestinal Candida in children with autism and its potential link with worse ASD symptoms. Gut Microbes Reports 2024, 1: 2358324. DOI: 10.1080/29933935.2024.2358324.Peer-Reviewed Original ResearchGut mycobiotaGene ampliconsOvergrowth of C. albicansDiverse microbial ecosystemFecal samplesFunctional roleAutism spectrum disorderFungal compositionS. cerevisiaeSaccharomyces cerevisiaeShotgun metagenomicsC. albicansMicrobial ecosystemGI microbiotaAutism Treatment Evaluation ChecklistMycobiotaFungal constituentsGI symptomsIncidence of GI disordersAutism severityGutCandidaGI ecosystemGastrointestinal (GI) tractAutism spectrum disorder symptomsImpact of Suramin on Key Pathological Features of Sporadic Alzheimer’s Disease-Derived Forebrain Neurons
Culibrk R, Ebbert K, Yeisley D, Chen R, Qureshi F, Hahn J, Hahn M. Impact of Suramin on Key Pathological Features of Sporadic Alzheimer’s Disease-Derived Forebrain Neurons. Journal Of Alzheimer’s Disease 2024, 98: 301-318. PMID: 38427475, DOI: 10.3233/jad-230600.Peer-Reviewed Original ResearchConceptsAkt/mTOR Signaling PathwaySignaling pathwaySynaptic puncta densityAlzheimer's diseaseSuramin treatmentPuncta densityForebrain neuronsRegulation of autophagyIPSC-derived neuronsAmyloid-bSporadic ADPathological featuresAD-related biomarkersP-P70S6KExposure to suraminModulation of autophagyEffect of suraminAutophagy inhibitor chloroquinePluripotent stem cellsAutophagyInhibitor chloroquineNeural progenitorsDegree of dysregulationAkt/mTORAutophagy inducer rapamycin
2022
Effects of Stromal Cell Conditioned Medium and Antipurinergic Treatment on Macrophage Phenotype
Arabiyat A, Yeisley D, Güiza-Argüello V, Qureshi F, Culibrk R, Hahn J, Hahn M. Effects of Stromal Cell Conditioned Medium and Antipurinergic Treatment on Macrophage Phenotype. Tissue Engineering Part C Methods 2022, 28: 656-671. PMID: 36329666, PMCID: PMC9807257, DOI: 10.1089/ten.tec.2022.0123.Peer-Reviewed Original ResearchShotgun Metagenomics Study Suggests Alteration in Sulfur Metabolism and Oxidative Stress in Children with Autism and Improvement after Microbiota Transfer Therapy
Nirmalkar K, Qureshi F, Kang D, Hahn J, Adams J, Krajmalnik-Brown R. Shotgun Metagenomics Study Suggests Alteration in Sulfur Metabolism and Oxidative Stress in Children with Autism and Improvement after Microbiota Transfer Therapy. International Journal Of Molecular Sciences 2022, 23: 13481. PMID: 36362265, PMCID: PMC9654974, DOI: 10.3390/ijms232113481.Peer-Reviewed Original ResearchConceptsMicrobiota transfer therapyGut microbial communityBifidobacterium bifidumSulfur metabolismFunctional genesShotgun metagenomic sequencingShotgun metagenomic studiesMetatranscriptomic studiesMetagenomic studiesShotgun sequencingGene ampliconsMicrobial genesMetagenomic sequencingMicrobiome therapiesFolate biosynthesisFunctional gene expressionMetabolic pathway analysisGut microbiotaTaxonomic analysisBeneficial microbesFiber consumersRelative abundanceGene expressionMetabolic pathwaysPathway analysisTowards the development of a diagnostic test for autism spectrum disorder: Big data meets metabolomics
Qureshi F, Hahn J. Towards the development of a diagnostic test for autism spectrum disorder: Big data meets metabolomics. The Canadian Journal Of Chemical Engineering 2022, 101: 9-17. PMID: 36591338, PMCID: PMC9799131, DOI: 10.1002/cjce.24594.Peer-Reviewed Original ResearchAutism spectrum disorderOne-carbon metabolismMetabolomics dataHeterogeneous presentationDiagnostic testsBiochemical measurementsBiochemical testsTD cohortsNeurodevelopmental disordersSpectrum disorderDisordersBiological mechanismsDiagnosisASD biomarkersAutism spectrum disorder diagnosisDiagnosis of autism spectrum disorderMetabolomicsRepetitive behaviorsPathophysiologyEtiologyMultivariate Analysis of Metabolomic and Nutritional Profiles among Children with Autism Spectrum Disorder
Qureshi F, Adams J, Audhya T, Hahn J. Multivariate Analysis of Metabolomic and Nutritional Profiles among Children with Autism Spectrum Disorder. Journal Of Personalized Medicine 2022, 12: 923. PMID: 35743708, PMCID: PMC9224818, DOI: 10.3390/jpm12060923.Peer-Reviewed Original ResearchReceiver operating curveMetabolomic patternsUnivariate analysisBiomarker panelMultivariate analysisMethylation biomarkersOperating curveMultivariate modelMetabolic differencesMachine-learning techniquesTranssulfuration pathwayBiomarkersMetabolitesMeasurements of childrenPhysiological pathwaysGroupNutritional profileMetabolomic Patterns Observed among Children with Autism Spectrum Disorder following Vitamin/Mineral Supplementation
Qureshi F, Adams J, Hahn J. Metabolomic Patterns Observed among Children with Autism Spectrum Disorder following Vitamin/Mineral Supplementation. IFAC-PapersOnLine 2022, 55: 156-160. DOI: 10.1016/j.ifacol.2023.01.034.Peer-Reviewed Original ResearchMetabolomic patternsNutritional supplementation studiesPathogenesis of autism spectrum disorderAutism spectrum disorderCohort of childrenNutritional interventionBiochemical measurementsVitamin/mineral supplementsCohortSupplementation studiesSpectrum disorderRecipient behaviorAutism spectrum disorder cohortDisordersChildrenMetabolomicsInterventionEtiologyPathogenesisVitamin/mineralsRecipients
2020
Multivariate Analysis of Fecal Metabolites from Children with Autism Spectrum Disorder and Gastrointestinal Symptoms before and after Microbiota Transfer Therapy
Qureshi F, Adams J, Hanagan K, Kang D, Krajmalnik-Brown R, Hahn J. Multivariate Analysis of Fecal Metabolites from Children with Autism Spectrum Disorder and Gastrointestinal Symptoms before and after Microbiota Transfer Therapy. Journal Of Personalized Medicine 2020, 10: 152. PMID: 33023268, PMCID: PMC7712156, DOI: 10.3390/jpm10040152.Peer-Reviewed Original ResearchPlasma metabolite profilesFecal microbiota transplantationMicrobiota transfer therapyTransfer therapyMultivariate analysisUltrahigh performance liquid chromatography-tandem mass spectroscopyFecal metabolite profilesAnalysis of fecal metabolitesGastrointestinal (GI) symptomsLiquid chromatography-tandem mass spectroscopyFecal metabolitesGastrointestinal symptomsMetabolite modelMicrobiota transplantationIndividual metabolitesMedian differenceProfile of childrenPlasma metabolitesMetabolite profilesAutism spectrum disorderCohortTD cohortsTherapySpectrum disorderTreatment