Emmanuel Akintoye, MD, MPH
Assistant Professor of Medicine (Cardiovascular Medicine)Cards
About
Research
Publications
2025
Atrial Functional Tricuspid Regurgitation Contemporary Characteristics, Outcomes, and Novel Risk Score
Fava A, Nakhla M, Hajj Ali A, Akintoye E, Akyuz K, Arockiam A, Haroun E, El Dahdah J, Liao Y, Popovic Z, Gillinov M, Pettersson G, Griffin B, Desai M, Wang T. Atrial Functional Tricuspid Regurgitation Contemporary Characteristics, Outcomes, and Novel Risk Score. JACC Advances 2025, 4: 101623. PMID: 40009906, PMCID: PMC11908566, DOI: 10.1016/j.jacadv.2025.101623.Peer-Reviewed Original ResearchRegurgitant orifice areaRight atrial volumeAF-TRTricuspid regurgitationAtrial volumeOrifice areaAtrial functional tricuspid regurgitationAssociated with 1-year mortalityEffective regurgitant orifice areaRisk scoreFunctional tricuspid regurgitationSevere tricuspid regurgitationEffective regurgitant orificeRight heart failureCohort of patientsSystolic pressure ratioIncreasing clinical recognitionMultivariate logistic regressionMedian survivalAdverse prognosticatorEchocardiographic characteristicsConsecutive patientsValve lesionsPoor prognosisRisk stratification
2024
Long-Term Outcomes of Patients With Apical Hypertrophic Cardiomyopathy Utilizing a New Risk Score
Hajj-Ali A, Gaballa A, Akintoye E, Jadam S, Ramchand J, Xu B, Ospina S, Thamilarasan M, Smedira N, Popovic Z, Desai M. Long-Term Outcomes of Patients With Apical Hypertrophic Cardiomyopathy Utilizing a New Risk Score. JACC Advances 2024, 3: 101235. PMID: 39512540, PMCID: PMC11540864, DOI: 10.1016/j.jacadv.2024.101235.Peer-Reviewed Original ResearchApical hypertrophic cardiomyopathyRight ventricular systolic pressureLeft atrial volume indexAtrial volume indexVentricular systolic pressureRisk scoreApical aneurysmEnd pointsHypertrophic cardiomyopathyMean left ventricle ejection fractionSystolic pressureLong-term outcomes of patientsApical hypertrophic cardiomyopathy patientsVolume indexBaseline cardiac magnetic resonanceComposite primary end pointPrimary end pointOutcomes of patientsVentricle ejection fractionDelayed gadolinium enhancementCardiac magnetic resonanceComposite end pointLong-term outcomesComposite event rateLeft ventricle apexLongitudinal Assessment of Left Atrial Remodeling in Patients With Chronic Severe Aortic Regurgitation
Akintoye E, El Dahdah J, Dabbagh M, Patel H, Badwan O, Braghieri L, Chedid El Helou M, Kassab J, Jellis C, Desai M, Rodriguez L, Grimm R, Roselli E, Griffin B, Popovic Z. Longitudinal Assessment of Left Atrial Remodeling in Patients With Chronic Severe Aortic Regurgitation. JACC Cardiovascular Imaging 2024, 17: 1133-1145. PMID: 38878040, DOI: 10.1016/j.jcmg.2024.04.007.Peer-Reviewed Original ResearchLeft atrial volume indexLeft atrial reservoir strainAortic regurgitationLV parametersAssociated with survival benefitMedian follow-up periodChronic severe aortic regurgitationLeft ventricular (LVShort-term follow-upOptimal discriminatory thresholdsSevere aortic regurgitationAtrial volume indexIncremental prognostic valueAtrial reservoir strainLeft atrial remodelingFollow-up periodAssociated with survivalPredicting adverse eventsReservoir strainSerial echocardiographySevere ARSurvival benefitLA remodelingLV remodelingPrognostic valueTrends in Age, Sex, and Racial Differences in the Incidence of Infective Endocarditis in Florida and New York
Anuforo A, Aneni E, Akintoye E, Anikpezie N, Patel S, Soipe A, Olojakpoke E, Burke D, Latorre J, Khandelwal P, Chaturvedi S, Ovbiagele B, Otite F. Trends in Age, Sex, and Racial Differences in the Incidence of Infective Endocarditis in Florida and New York. Circulation 2024, 149: 1391-1393. PMID: 38648273, DOI: 10.1161/circulationaha.123.066921.Peer-Reviewed Original ResearchCONTEMPORARY CHARACTERISTICS, OUTCOMES AND NOVEL RISK SCORE FOR SIGNIFICANT ISOLATED ATRIAL FUNCTIONAL TRICUSPID REGURGITATION
Wang T, Fava A, Nakhla M, Ali A, Akintoye E, Akyuz K, Gillinov A, Griffin B, Desai M. CONTEMPORARY CHARACTERISTICS, OUTCOMES AND NOVEL RISK SCORE FOR SIGNIFICANT ISOLATED ATRIAL FUNCTIONAL TRICUSPID REGURGITATION. Journal Of The American College Of Cardiology 2024, 83: 2133. DOI: 10.1016/s0735-1097(24)04123-8.Peer-Reviewed Original ResearchAGREEMENT BETWEEN PROXIMAL ISOVELOCITY SURFACE AREA-BASED METHOD OF TRICUSPID REGURGITATION QUANTIFICATION WITH AND WITHOUT COLOR DOPPLER BASELINE SHIFT
Nakhla M, Ali A, Akintoye E, Fava A, Akyuz K, Popovic Z, Pettersson G, Gillinov A, Xu B, Griffin B, Desai M, Wang T. AGREEMENT BETWEEN PROXIMAL ISOVELOCITY SURFACE AREA-BASED METHOD OF TRICUSPID REGURGITATION QUANTIFICATION WITH AND WITHOUT COLOR DOPPLER BASELINE SHIFT. Journal Of The American College Of Cardiology 2024, 83: 1463. DOI: 10.1016/s0735-1097(24)03453-3.Peer-Reviewed Original ResearchRole of Cardiac MRI in Pericardial Diseases
Anthony C, Akintoye E, Wang T, Klein A. Role of Cardiac MRI in Pericardial Diseases. Current Cardiovascular Imaging Reports 2024, 17: 43-51. DOI: 10.1007/s12410-024-09591-x.Peer-Reviewed Original ResearchDiagnosis of pericardial diseaseResponse to therapyPericardial diseaseCardiac MRIDiagnosis of pericarditisInitiation of treatmentCardiac MRI techniquesRecurrent pericarditisAcute pericarditisMedical therapyAdjunctive roleTherapyPericarditisDiagnosisDiseaseImaging toolCardiacPatientsMRISummaryCMRPrognosis
2023
Correction to: Echo Doppler Parameters of Diastolic Function
Anthony C, Akintoye E, Wang T, Klein A. Correction to: Echo Doppler Parameters of Diastolic Function. Current Cardiology Reports 2023, 25: 907-907. PMID: 37498451, DOI: 10.1007/s11886-023-01922-6.Peer-Reviewed Original ResearchImaging biomarkers in aortic valve disease: it is time to shift the focus to the myocardium
Kwon D, Akintoye E. Imaging biomarkers in aortic valve disease: it is time to shift the focus to the myocardium. European Heart Journal - Cardiovascular Imaging 2023, 24: 863-865. PMID: 37220177, DOI: 10.1093/ehjci/jead095.Peer-Reviewed Original ResearchPrognostic Utility of Left Atrial Strain to Predict Thrombotic Events and Mortality in Amyloid Cardiomyopathy
Akintoye E, Majid M, Klein A, Hanna M. Prognostic Utility of Left Atrial Strain to Predict Thrombotic Events and Mortality in Amyloid Cardiomyopathy. JACC Cardiovascular Imaging 2023, 16: 1371-1383. PMID: 37940322, DOI: 10.1016/j.jcmg.2023.01.015.Peer-Reviewed Original ResearchConceptsThrombotic eventsAmyloid cardiomyopathyAtrial fibrillationLA contractileLA strainLA contractile strainModest discriminatory abilityPrognostic staging systemRisk stratification toolLeft Atrial StrainHigh thrombotic riskAtrial strainPrognostic utilityStratification toolPrognostic valueC-statisticRespective HRsStaging systemThrombotic riskACM patientsSD decreaseAF casesPredictive valuePatientsDiscriminatory ability
Academic Achievements & Community Involvement
Clinical Care
Overview
Emmanuel Akintoye, MD, MPH, is a cardiologist who specializes in multimodality and structural imaging of the heart. He is board certified in internal medicine, cardiovascular disease, cardiovascular CT, MRI, echocardiography, and nuclear cardiology.
As a multimodality specialist, he guides the management of a patient with known or suspected cardiovascular disease through the use of noninvasive imaging technologies—whether that is a single test or multiple tests. He performs structural imaging for patients who have an abnormality in the structure of the heart or in one of its components.
“Growing up, I was always motivated about finding solutions to complex challenges that impact human life,” Dr. Akintoye says. “Being a cardiologist and a multimodality imager provided me the opportunity to address complex heart disease using state-of-the-art, noninvasive technologies. There also is a sense of fulfilment that comes with improving a patient’s quality of life and overall survival.”
An assistant professor of medicine (cardiovascular) at Yale School of Medicine, Dr. Akintoye focuses his research mainly on the application of multimodality imaging in disease affecting the heart’s valves.
Clinical Specialties
Cardiovascular Medicine