Emily Davidson
About
Research
Publications
2022
Assessing extraction-analysis methodology to detect fluorotelomer alcohols (FTOH), a class of perfluoroalkyl and polyfluoroalkyl substances (PFAS), in artificial turf fibers and crumb rubber infill
Zuccaro P, Licato J, Davidson E, Thompson D, Vasiliou V. Assessing extraction-analysis methodology to detect fluorotelomer alcohols (FTOH), a class of perfluoroalkyl and polyfluoroalkyl substances (PFAS), in artificial turf fibers and crumb rubber infill. Case Studies In Chemical And Environmental Engineering 2022, 7: 100280. PMID: 37575658, PMCID: PMC10423336, DOI: 10.1016/j.cscee.2022.100280.Peer-Reviewed Original ResearchExposure to Per- and polyfluoroalkyl substances is associated with altered pancreatic β-cell function
Goodrich J, Davidson* E, Baumert B, Chen Y, Walker D, Lin X, Hu X, Alderete T, Chen Z, Valvi D, Fuentes Z, Rock S, Berhane K, Gilliland F, Jones D, Goran M, Conti D, Vasiliou† V, Chatzi† L. Exposure to Per- and polyfluoroalkyl substances is associated with altered pancreatic β-cell function. ISEE Conference Abstracts 2022, 2022 DOI: 10.1289/isee.2022.p-0352.Peer-Reviewed Original ResearchOxidative stress, glutathione, and CYP2E1 in 1,4-dioxane liver cytotoxicity and genotoxicity: insights from animal models
Wang Y, Charkoftaki G, Davidson E, Orlicky D, Tanguay R, Thompson D, Vasiliou V, Chen Y. Oxidative stress, glutathione, and CYP2E1 in 1,4-dioxane liver cytotoxicity and genotoxicity: insights from animal models. Current Opinion In Environmental Science & Health 2022, 29: 100389. PMID: 37483863, PMCID: PMC10361651, DOI: 10.1016/j.coesh.2022.100389.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsOxidative stressUnique mouse modelRelevant low dosesDirect genotoxic effectsLiver cytotoxicityCYP2E1 activationMouse modelAnimal modelsHuman studiesCarcinogenic pathwaysLiver carcinogenicityLow dosesCausal roleGenotoxic effectsHuman exposureUndetermined mechanismPublic healthCarcinogenicityLiver genotoxicityDrinking water contaminantsMechanistic dataGenotoxicityFuture animalCytotoxicityCYP2E1Oxidative stress induces inflammation of lens cells and triggers immune surveillance of ocular tissues
Thompson B, Davidson EA, Chen Y, Orlicky DJ, Thompson DC, Vasiliou V. Oxidative stress induces inflammation of lens cells and triggers immune surveillance of ocular tissues. Chemico-Biological Interactions 2022, 355: 109804. PMID: 35123994, PMCID: PMC9136680, DOI: 10.1016/j.cbi.2022.109804.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcysteineAnimalsButhionine SulfoximineCell LineChemokine CCL7CytokinesDown-RegulationEpithelial CellsEpithelial-Mesenchymal TransitionEyeGlutamate-Cysteine LigaseImmunity, InnateLens, CrystallineLeukocytesMiceMice, Inbred C57BLMice, KnockoutOxidative StressReactive Oxygen SpeciesUp-RegulationConceptsPosterior capsule opacificationCytokine expressionKO miceImmune surveillanceOxidative stressLens epithelial cellsOcular structuresLens cellsDevelopment of PCOEpithelial cellsInnate immune cellsExpression of cytokinesEx vivo inductionOcular surface tissuesExpression of markersImmune response genesCON miceControl miceCapsule opacificationImmune cellsPostnatal dayΑ-SMAMouse modelOcular tissuesVivo inductionQuantitative analysis of short-chain fatty acids in human plasma and serum by GC–MS
Yao L, Davidson E, Shaikh M, Forsyth C, Prenni J, Broeckling C. Quantitative analysis of short-chain fatty acids in human plasma and serum by GC–MS. Analytical And Bioanalytical Chemistry 2022, 414: 4391-4399. PMID: 35091760, DOI: 10.1007/s00216-021-03785-8.Peer-Reviewed Original Research
2021
Oxidative stress and genotoxicity in 1,4-dioxane liver toxicity as evidenced in a mouse model of glutathione deficiency
Chen Y, Wang Y, Charkoftaki G, Orlicky DJ, Davidson E, Wan F, Ginsberg G, Thompson DC, Vasiliou V. Oxidative stress and genotoxicity in 1,4-dioxane liver toxicity as evidenced in a mouse model of glutathione deficiency. The Science Of The Total Environment 2021, 806: 150703. PMID: 34600989, PMCID: PMC8633123, DOI: 10.1016/j.scitotenv.2021.150703.Peer-Reviewed Original ResearchConceptsOxidative stressLiver cytotoxicityGlutamate-cysteine ligase modifier subunitWild-type micePrimary target organRecent mouse studiesCYP2E1 inductionLiver toxicitySubchronic exposureNrf2 inductionOxidative DNA damageCancer riskMouse modelAnti-oxidative responseDNA damageTarget organsAnimal studiesLiver carcinogenicityRedox dysregulationEarly changesHealth CanadaNull miceMouse studiesNuclear factorCarcinogenic mechanismsImpaired GSH biosynthesis disrupts eye development, lens morphogenesis and PAX6 function
Thompson B, Chen Y, Davidson EA, Garcia-Milian R, Golla JP, Apostolopoulos N, Orlicky DJ, Schey K, Thompson DC, Vasiliou V. Impaired GSH biosynthesis disrupts eye development, lens morphogenesis and PAX6 function. The Ocular Surface 2021, 22: 190-203. PMID: 34425299, PMCID: PMC8560581, DOI: 10.1016/j.jtos.2021.08.010.Peer-Reviewed Original ResearchConceptsHEK293T cellsEye developmentGSH biosynthesisTransactivation activityPax6 functionReactive oxygen speciesSubsequent gene ontologyCell identity genesButhionine sulfoximineEpithelial cell identityRNA-seq analysisIngenuity Pathway AnalysisKey upstream regulatorIdentity genesCell identityGene OntologyRNA-seqImmune response genesBioinformatics analysisResponse genesGlutathione biosynthesisLens morphogenesisMolecular consequencesUpstream regulatorMicrophthalmia phenotype
2020
Overview of PAX gene family: analysis of human tissue-specific variant expression and involvement in human disease
Thompson B, Davidson EA, Liu W, Nebert DW, Bruford EA, Zhao H, Dermitzakis ET, Thompson DC, Vasiliou V. Overview of PAX gene family: analysis of human tissue-specific variant expression and involvement in human disease. Human Genetics 2020, 140: 381-400. PMID: 32728807, PMCID: PMC7939107, DOI: 10.1007/s00439-020-02212-9.Peer-Reviewed Original ResearchConceptsPax proteinsTranscript variant expressionHuman diseasesFunctional rolePax gene familyMyriad human diseasesPax family membersVariant expressionPotential functional significanceBox genesPax genesGene familyTranscriptional regulationCell identityLineage determinationOrgan developmentTranscription factorsMaster regulatorAdditional speciesCell differentiationDevelopmental diseasesGenomic updateFunctional significanceProteinGenes
2017
Increasing dietary EPA and DHA influence estimated fatty acid desaturase activity in systemic organs which is reflected in the red blood cell in mice
Davidson EA, Pickens CA, Fenton JI. Increasing dietary EPA and DHA influence estimated fatty acid desaturase activity in systemic organs which is reflected in the red blood cell in mice. International Journal Of Food Sciences And Nutrition 2017, 69: 183-191. PMID: 28697636, DOI: 10.1080/09637486.2017.1348494.Peer-Reviewed Original ResearchConceptsDietary eicosapentaenoic acidEnzyme activity estimatesRed blood cellsDocosahexaenoic acidEicosapentaenoic acidDesaturase activityBlood cellsPhospholipid FA compositionDelta-6 desaturaseDHA influencesFatty acid metabolismTissue FA compositionFatty acid desaturase activitySystemic organsAdipose tissuePercent of energyFA compositionDelta 5Acid metabolismMuscleTissueMiceDifferential influenceCellsLung
2016
Red blood cell PUFAs reflect the phospholipid PUFA composition of major organs
Fenton JI, Gurzell EA, Davidson EA, Harris WS. Red blood cell PUFAs reflect the phospholipid PUFA composition of major organs. Prostaglandins Leukotrienes And Essential Fatty Acids 2016, 112: 12-23. PMID: 27637336, DOI: 10.1016/j.plefa.2016.06.004.Peer-Reviewed Original ResearchConceptsRed blood cellsCoronary heart diseasePhospholipid fatty acid compositionNumerous clinical trialsAmerican Heart AssociationPotential risk factorsFatty acid compositionFatty acidsFatty acid levelsLCPUFA exposureLCPUFA profilesRBC SFADietary SFAHeart AssociationLCPUFA levelsHeart diseaseRisk factorsClinical trialsCurrent recommendationsDietary supplementationMouse dietHealth outcomesNutritional supplementsMajor organsLCPUFA