Emily Branham
About
Biography
Emily Branham earned a BS in Chemistry, a Biology minor, and a Creative Writing minor from the University of North Carolina at Chapel Hill, where she graduated in 2017 with Highest Distinction overall and Honors in Chemistry. At Yale University, Emily is a Chemistry/Biology Interface (CBI) Training Program Scholar with support provided by the National Institute of Health. She received an Honorable Mention from the National Science Foundation Graduate Research Fellowship Program in 2019.
During her first few years at Yale, Emily was a graduate student in the Spiegel Lab, where she focused on synthetically engineering monoclonal antibodies with the goal of improved removal of circulating proteins and enriched therapeutic applications. Emily earned her MS in Chemistry and advanced to candidacy before joining the DiMaio lab in 2020, where she continues to pursue her PhD in Chemistry. Her current research focuses on engineering genetically expressible, small transmembrane proteins (traptamers) to facilitate the proteasomal degradation of disease-relevant, endogenous transmembrane proteins. She intends to extend this PROTAC-like technology to the study of HPV as a way to identify new candidate proteins involved in viral infection.
Emily’s varied research experiences, which span biology, biochemistry, chemical biology, and synthetic chemistry, helped her discover and tailor her interest in applying chemistry to the study of biologically and medically relevant problems. In her free time, Emily enjoys relaxing at home with her husband, teaching her three Australian Shepherds new tricks, watching tv with her cats, writing, cooking (and eating), and playing violin in the Hamden Symphony Orchestra.
Departments & Organizations
Education & Training
- MS
- Yale University, Chemistry (2019)
- BS (Hon)
- The University of North Carolina at Chapel Hill, Chemistry (2017)
Research
Publications
2021
Bifunctional small molecules that mediate the degradation of extracellular proteins
Caianiello DF, Zhang M, Ray JD, Howell RA, Swartzel JC, Branham EMJ, Chirkin E, Sabbasani VR, Gong AZ, McDonald DM, Muthusamy V, Spiegel DA. Bifunctional small molecules that mediate the degradation of extracellular proteins. Nature Chemical Biology 2021, 17: 947-953. PMID: 34413525, DOI: 10.1038/s41589-021-00851-1.Peer-Reviewed Original ResearchConceptsExtracellular proteinsTarget proteinsUbiquitin-proteasome systemBifunctional small moleculesSynthetic moleculesProtein degradationIntracellular proteinsProinflammatory cytokine proteinProteinLysosomal proteasesTernary complexSmall moleculesPromising therapeutic strategyCytokine proteinsTherapeutic strategiesMoleculesDegradationProteaseDisease treatmentExperimental evidence
2016
Bifunctional conjugates with potent inhibitory activity towards cyclooxygenase and histone deacetylase
Raji I, Yadudu F, Janeira E, Fathi S, Szymczak L, Kornacki J, Komatsu K, Li J, Mrksich M, Oyelere A. Bifunctional conjugates with potent inhibitory activity towards cyclooxygenase and histone deacetylase. Bioorganic & Medicinal Chemistry 2016, 25: 1202-1218. PMID: 28057407, PMCID: PMC5291751, DOI: 10.1016/j.bmc.2016.12.032.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic AgentsCelecoxibCell CycleCell LineCell ProliferationCell SurvivalCyclooxygenase InhibitorsDose-Response Relationship, DrugDrug Screening Assays, AntitumorHistone Deacetylase InhibitorsHistone DeacetylasesHumansIndomethacinModels, MolecularMolecular StructureProstaglandin-Endoperoxide SynthasesStructure-Activity RelationshipConceptsProstate cancer cell linesCancer cell linesCompound 2bAndrogen-dependent prostate cancer cell lineAndrogen-independent prostate cancer cell linesCell linesIndependent prostate cancer cell linesHistone deacetylasesCell cycle progressionTumor-selective cytotoxicityCOX-2 relative to COX-1Growth of cancer cell linesCompound 11bCompound 8Inhibitory activityCOX-2 selectivityDU-145Lead compoundsCOX-2Anti-HDAC activityCOX-1CyclooxygenaseG0/G1 arrestHealthy cellsAnti-proliferative activity
Academic Achievements & Community Involvement
Links
Get In Touch
Contacts
Locations
DiMaio Lab
Lab
Sterling Hall of Medicine, I-Wing
333 Cedar Street, Rm 119
New Haven, CT 06510