Darin Dolezal, MD, PhD

The goal of one ongoing research project, which is supported by an intradepartmental Chair’s Challenge grant, is to detect driver and resistance mutations in pleural fluid-derived circulating tumor DNA from patients with lung adenocarcinoma. The aim of this project is to use an error-suppressed multiplex deep sequencing platform, originally designed to detect low abundance tumor-specific mutations in plasma, to detect mutations with high sensitivity in the supernatants of malignant pleural effusions.