Corey Horien
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Research
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Featured Publications
A generalizable connectome-based marker of in-scan sustained attention in neurodiverse youth
Horien C, Greene A, Shen X, Fortes D, Brennan-Wydra E, Banarjee C, Foster R, Donthireddy V, Butler M, Powell K, Vernetti A, Mandino F, O'Connor D, Lake E, McPartland J, Volkmar F, Chun M, Chawarska K, Rosenberg M, Scheinost D, Constable R. A generalizable connectome-based marker of in-scan sustained attention in neurodiverse youth. Cerebral Cortex 2022, 33: 6320-6334. PMID: 36573438, PMCID: PMC10183743, DOI: 10.1093/cercor/bhac506.Peer-Reviewed Original ResearchConceptsAttention taskAttentional stateConnectome-based predictive modelingNeurodiverse conditionsSustained attention taskAttention network modelSample of youthNeurotypical participantsSustained attentionBrain correlatesNeurobiological correlatesAttention networkIndividual participantsSeparate samplesYouthParticipantsHead motionTaskCorrelatesAttentionAutismConfoundsNetwork modelGeneralizesHealthcare settingsWhy is everyone talking about brain state?
Greene A, Horien C, Barson D, Scheinost D, Constable R. Why is everyone talking about brain state? Trends In Neurosciences 2023, 46: 508-524. PMID: 37164869, PMCID: PMC10330476, DOI: 10.1016/j.tins.2023.04.001.Peer-Reviewed Original ResearchBrain–phenotype models fail for individuals who defy sample stereotypes
Greene AS, Shen X, Noble S, Horien C, Hahn CA, Arora J, Tokoglu F, Spann MN, Carrión CI, Barron DS, Sanacora G, Srihari VH, Woods SW, Scheinost D, Constable RT. Brain–phenotype models fail for individuals who defy sample stereotypes. Nature 2022, 609: 109-118. PMID: 36002572, PMCID: PMC9433326, DOI: 10.1038/s41586-022-05118-w.Peer-Reviewed Original ResearchConceptsBrain-phenotype relationshipsBrain functional organizationCognitive constructsIndividual differencesNeurocognitive measuresBrain activityNeurocognitive scoresStereotypical profileNeural targetsClinical interventionsNeural circuitsFunctional organizationIndividualsSuch relationshipsData-driven approachRelationshipStereotypesFunctional Connectome–Based Predictive Modeling in Autism
Horien C, Floris DL, Greene AS, Noble S, Rolison M, Tejavibulya L, O'Connor D, McPartland JC, Scheinost D, Chawarska K, Lake EMR, Constable RT. Functional Connectome–Based Predictive Modeling in Autism. Biological Psychiatry 2022, 92: 626-642. PMID: 35690495, PMCID: PMC10948028, DOI: 10.1016/j.biopsych.2022.04.008.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsThe individual functional connectome is unique and stable over months to years
Horien C, Shen X, Scheinost D, Constable RT. The individual functional connectome is unique and stable over months to years. NeuroImage 2019, 189: 676-687. PMID: 30721751, PMCID: PMC6422733, DOI: 10.1016/j.neuroimage.2019.02.002.Peer-Reviewed Original ResearchConceptsHigh ID ratesIndividual differencesFunctional connectomeIndividual functional connectomesStable individual differencesID rateResting-state fMRI datasetsFrontoparietal networkFunctional connectivityParietal cortexFMRI datasetsIdiosyncratic aspectsConnectomeHead motionEntire brainFMRIBrainCortexSpecific datasetDifferencesConnectivity
2025
Impulsivity and neuroticism share distinct functional connectivity signatures with alcohol-use risk in youth
Cheng A, Lichenstein S, Chaarani B, Liang Q, Babaeianjelodar M, Riley S, Luo W, Horien C, Greene A, Banaschewski T, Bokde A, Desrivières S, Flor H, Grigis A, Gowland P, Heinz A, Brühl R, Martinot J, Martinot M, Artiges E, Nees F, Papadopoulos Orfanos D, Poustka L, Hohmann S, Holz N, Baeuchl C, Smolka M, Vaidya N, Walter H, Whelan R, Schumann G, Constable R, Pearlson G, Garavan H, Yip S. Impulsivity and neuroticism share distinct functional connectivity signatures with alcohol-use risk in youth. Molecular Psychiatry 2025, 1-10. PMID: 40913110, DOI: 10.1038/s41380-025-03196-6.Peer-Reviewed Original ResearchFunctional connectivity signaturesNeural signaturesConnectivity signaturesConnectome-based predictive modelingUnique neural mechanismsFunctional connectivity dataStudy of adolescent developmentDimensional traitsNegative affectDimensional phenotypesDefault modeNeural mechanismsNeuroticismAlcohol-useCerebellar networkYouth impulsivityAdolescent developmentCanonical networksAssociated with riskConnectivity dataNetwork anatomyComplex neural networksImpulseRisk behaviorsTraitsWhole-brain functional connectivity predicts regional tau PET in preclinical Alzheimer’s disease
Abuwarda H, Trainer A, Horien C, Shen X, Moret S, Ju S, Constable R, Fredericks C. Whole-brain functional connectivity predicts regional tau PET in preclinical Alzheimer’s disease. Brain Communications 2025, 7: fcaf274. PMID: 40735265, PMCID: PMC12305425, DOI: 10.1093/braincomms/fcaf274.Peer-Reviewed Original ResearchAlzheimer's disease pathologyAlzheimer's diseaseTau elevationTau-PET signalTau-PETTau modelDisease pathologyAbnormal accumulationPreclinical Alzheimer's diseaseAmyloid-bWhole-brain FCTau pathologyAssociated with tauFunctional connectivityRegional tauTauFunctional connectomeFC-based modelsWhole-brainPET signalAlzheimerConnectome-based predictive modelingWhole-brain functional connectivityDisease clinical spectrumTarget regionFunctional Connectome Correlates of Laterality Preferences: Insights into Hand, Foot, and Eye Dominance across the Lifespan
Tejavibulya L, Horien C, Fredericks C, Ficek B, Westwater M, Scheinost D. Functional Connectome Correlates of Laterality Preferences: Insights into Hand, Foot, and Eye Dominance across the Lifespan. ENeuro 2025, 12: eneuro.0580-24.2025. PMID: 40473471, PMCID: PMC12244319, DOI: 10.1523/eneuro.0580-24.2025.Peer-Reviewed Original ResearchLateral preferenceFunctional connectomeWhole-brain functional connectomePosterior temporal areasBrain functional connectivityWhole-brain connectomePrefrontal lobeNormative variationCerebellar regionsFunctional connectivityDevelopmental shiftTemporal lobeBrain connectivityWhole-brainLeft-handednessFoot preferenceRight-handednessTemporal areaIncreased connectivityResting-state functional connectomesEffect sizeSignificant associationConnectivity patternsBrain hemispheresHandednessNeural activity underpins dynamic BOLD signals: findings from simultaneous wide-field fluorescent calcium imaging and fMRI.
Mandino F, Horien C, Shen X, Papademetris X, Keilholz S, Xu N, Lake E. Neural activity underpins dynamic BOLD signals: findings from simultaneous wide-field fluorescent calcium imaging and fMRI. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2025 DOI: 10.58530/2025/1012.Peer-Reviewed Original ResearchQuasi-periodic patternsBOLD fMRIMeasured whole brain activityBOLD fMRI dataCross-modal agreementWhole-brain activityDynamic activity patternsNeural underpinningsSpatiotemporal structureBOLD signalCalcium imagingFluorescence calcium imagingLow-frequencyBrain activityNeural activityCortical activitySubject levelFMRIActivity patternsBOLDNeural originInter-subject variabilityMultimodal identification of the mouse brain using simultaneous Ca2+ imaging and fMRI
Mandino F, Horien C, Shen X, Desrosiers-Grégoire G, Luo W, Markicevic M, Constable R, Papademetris X, Chakravarty M, Betzel R, Lake E. Multimodal identification of the mouse brain using simultaneous Ca2+ imaging and fMRI. Communications Biology 2025, 8: 665. PMID: 40287579, PMCID: PMC12033268, DOI: 10.1038/s42003-025-08037-4.Peer-Reviewed Original ResearchConceptsBOLD fMRIBOLD fMRI dataConnectome-based identificationCognitive neuroscientistsFMRI literatureHeterogeneous neurological conditionsWhole cortexFMRIMouse brainSimultaneous Ca2+ imagingCa2+ imagingAnimal modelsFluorescence calcium imagingCalcium imagingNeurological conditionsPersonalized treatmentNeuroimagingBOLDCortexNeuroscientistsBrainMiceMultimodal identificationCell-type specific signals