Bornali Bhattacharjee
Associate Research ScientistCards
About
Titles
Associate Research Scientist
Associate Director, Center for Infection and Immunity
Biography
Dr. Bornali Bhattacharjee, MS, PhD is a Research Associate Scientist at the Department of Immunobiology and the Associate Director at the Center for Infection & Immunity. Her role is to lead, coordinate and manage biomedical research projects that are geared towards understanding the immune trajectories of post-acute infection syndromes.
Her training and research interests lie at the interface of pathogen genomics, evolutionary biology and host-pathogen interaction. She earned her PhD in Molecular Epidemiology & Virology from Indian Statistical Institute & University of Calcutta. Her post-doctoral training was in Viral Genomics & Evolution at University of Massachusetts Medical School.
Departments & Organizations
- Center for Infection and Immunity
Education & Training
- PhD
- Indian Statistical Institute & University of Calcutta
- MS
- University of Calcutta, Biochemistry
Research
Publications
2024
Internal tremors and vibrations in long COVID: a cross-sectional study
Zhou T, Sawano M, Arun A, Caraballo C, Michelsen T, McAlpine L, Bhattacharjee B, Lu Y, Khera R, Huang C, Warner F, Herrin J, Iwasaki A, Krumholz H. Internal tremors and vibrations in long COVID: a cross-sectional study. The American Journal Of Medicine 2024 PMID: 39069199, DOI: 10.1016/j.amjmed.2024.07.008.Peer-Reviewed Original ResearchNew-onset conditionsInternal tremorLong COVID symptomsCOVID symptomsNon-Hispanic whitesCross-sectional studyQuality of lifeVisual analogue scaleWorse healthHealth statusStudy participantsDemographic characteristicsAnalogue scaleOutcome variablesNeurological conditionsLong COVIDMast cell disordersTreatment experienceHealthComorbiditiesSymptomsMedian agePeopleCell disordersThe PAX LC Trial: A Decentralized, Phase 2, Randomized, Double-blind Study of Nirmatrelvir/Ritonavir Compared with Placebo/Ritonavir for Long COVID
Krumholz H, Sawano M, Bhattacharjee B, Caraballo C, Khera R, Li S, Herrin J, Coppi A, Holub J, Henriquez Y, Johnson M, Goddard T, Rocco E, Hummel A, Al Mouslmani M, Putrino D, Carr K, Carvajal-Gonzalez S, Charnas L, De Jesus M, Ziegler F, Iwasaki A. The PAX LC Trial: A Decentralized, Phase 2, Randomized, Double-blind Study of Nirmatrelvir/Ritonavir Compared with Placebo/Ritonavir for Long COVID. The American Journal Of Medicine 2024 PMID: 38735354, DOI: 10.1016/j.amjmed.2024.04.030.Peer-Reviewed Original ResearchLC trialPROMIS-29Participants' homesTargeting viral persistencePlacebo-controlled trialDouble-blind studyElectronic health recordsCore Outcome MeasuresLong COVIDEQ-5D-5LRepeated measures analysisEvidence-based treatmentsPhase 2Double-blindParticipant-centred approachStudy drugPrimary endpointSecondary endpointsCommunity-dwellingHealth recordsHealthcare utilizationContiguous US statesViral persistencePatient groupDrug treatmentLong COVID Characteristics and Experience: A Descriptive Study From the Yale LISTEN Research Cohort
Sawano M, Wu Y, Shah R, Zhou T, Arun A, Khosla P, Kaleem S, Vashist A, Bhattacharjee B, Ding Q, Lu Y, Caraballo C, Warner F, Huang C, Herrin J, Putrino D, Michelsen T, Fisher L, Adinig C, Iwasaki A, Krumholz H. Long COVID Characteristics and Experience: A Descriptive Study From the Yale LISTEN Research Cohort. The American Journal Of Medicine 2024, 138: 712-720.e13. PMID: 38663793, DOI: 10.1016/j.amjmed.2024.04.015.Peer-Reviewed Original ResearchExperiences of peopleHealth statusLong COVIDLower health statusNew-onset conditionsCommunity support servicesNon-Hispanic whitesArray of healthQuality of lifeVisual analogue scaleMental healthPsychological distressPsychological statusDescriptive studyHealthcare systemMedian scoreSupport servicesResearch cohortSocial isolationDemographic characteristicsAnalogue scaleImpact of long COVIDHealthFinancial stressParticipants
2023
Distinguishing features of long COVID identified through immune profiling
Klein J, Wood J, Jaycox J, Dhodapkar R, Lu P, Gehlhausen J, Tabachnikova A, Greene K, Tabacof L, Malik A, Silva Monteiro V, Silva J, Kamath K, Zhang M, Dhal A, Ott I, Valle G, Peña-Hernández M, Mao T, Bhattacharjee B, Takahashi T, Lucas C, Song E, McCarthy D, Breyman E, Tosto-Mancuso J, Dai Y, Perotti E, Akduman K, Tzeng T, Xu L, Geraghty A, Monje M, Yildirim I, Shon J, Medzhitov R, Lutchmansingh D, Possick J, Kaminski N, Omer S, Krumholz H, Guan L, Dela Cruz C, van Dijk D, Ring A, Putrino D, Iwasaki A. Distinguishing features of long COVID identified through immune profiling. Nature 2023, 623: 139-148. PMID: 37748514, PMCID: PMC10620090, DOI: 10.1038/s41586-023-06651-y.Peer-Reviewed Original ResearchConceptsLong COVIDSARS-CoV-2Infection syndromeExaggerated humoral responseSoluble immune mediatorsEpstein-Barr virusPost-exertional malaiseCross-sectional studyHigher antibody responseImmune mediatorsImmune phenotypingImmune profilingHumoral responseAntibody responseLymphocyte populationsCOVID statusUnbiased machineCortisol levelsLC statusRelevant biomarkersViral pathogensSyndromeCOVIDFuture studiesBiological featuresIL-10/IL-6 ratio from nasal & oral swab samples, acts as an inflammatory indicator for COVID-19 patients infected with the delta variant
Biswas B, Roy S, Banerjee I, Jana S, Bhattacharjee B, Chakraborty S, Mondal A, Goswami R. IL-10/IL-6 ratio from nasal & oral swab samples, acts as an inflammatory indicator for COVID-19 patients infected with the delta variant. Heliyon 2023, 9: e16985. PMID: 37292329, PMCID: PMC10238278, DOI: 10.1016/j.heliyon.2023.e16985.Peer-Reviewed Original ResearchViral load patientsCOVID-19 patientsNon-vaccinated patientsViral loadIL-10/IL-6 ratioHyper-inflammatory immune responseMultiple pro-inflammatory cytokinesCT valuesIL-10/IL-6Control groupSwab samplesPro-inflammatory cytokinesRelease of multiple pro-inflammatory cytokinesOral swab samplesUninfected donorsICU supportStatus of vaccinationNasal swab samplesInflammatory indicatorsDisease progressionCytokine markersPatientsNon-vaccinated COVID-19 patientsNasal swabsUninfected individuals
2022
Influence of Sub-Inhibitory Dosage of Cefotaxime on Multidrug Resistant Staphylococcus haemolyticus Isolated from Sick Neonatal Care Unit
Chakraborty M, Bardhan T, Basu M, Bhattacharjee B. Influence of Sub-Inhibitory Dosage of Cefotaxime on Multidrug Resistant Staphylococcus haemolyticus Isolated from Sick Neonatal Care Unit. Antibiotics 2022, 11: 360. PMID: 35326823, PMCID: PMC8944431, DOI: 10.3390/antibiotics11030360.Peer-Reviewed Original ResearchExtracellular DNABiofilm formationS. haemolyticus isolatesBiofilm-forming abilityNon-susceptibilityGenerations of growthSick neonatal care unitCrystal violet assayAntibiotic non-susceptibilityNon-susceptible isolatesS. haemolyticusBiofilm productionNeonatal care unitStaphylococcus haemolyticusDosage of cefotaximeMDR isolatesExtracellular DNA levelsDoses of antibioticsConcentrations of cefotaximeCare of neonatesSub-optimal dosesCTX resistanceSepsis pathogensSub-optimal concentrationsNewborn infantsThe Species-Specific 282 Residue in the PB2 Subunit of the Polymerase Regulates RNA Synthesis and Replication of Influenza A Viruses Infecting Bat and Nonbat Hosts
Banerjee S, De A, Kedia N, Bhakta K, Wang L, Bhattacharjee B, Mondal A. The Species-Specific 282 Residue in the PB2 Subunit of the Polymerase Regulates RNA Synthesis and Replication of Influenza A Viruses Infecting Bat and Nonbat Hosts. Journal Of Virology 2022, 96: e02190-21. PMID: 35044213, PMCID: PMC8906409, DOI: 10.1128/jvi.02190-21.Peer-Reviewed Original ResearchConceptsBat influenza virusesInfluenza virus polymeraseInfluenza A virusVirus polymerasePB2 subunitIAV RNA polymeraseGenera of influenza virusesHost speciesAdaptation of influenza virusesInfluenza virusHuman cellsPolymerase subunit PB2RNA synthesis activitySpecies-specific signaturesHuman-specific signaturesAmino acid preferencesReduced polymerase activityAmino acid alterationsGlutamic acidA virusSurface antigen hemagglutininCross-species transmissionRNA polymerasePB2 proteinSignature residues
2021
Predominance of genomically defined A lineage of HPV16 over D lineage in Indian patients from eastern India with squamous cell carcinoma of the cervix in association with distinct oncogenic phenotypes
Mandal P, Bhattacharjee B, Sen S, Bhattacharya A, Saha S, Chowdhury R, Mondal N, Chakrabarty B, Chatterjee T, Roy S, Sengupta S. Predominance of genomically defined A lineage of HPV16 over D lineage in Indian patients from eastern India with squamous cell carcinoma of the cervix in association with distinct oncogenic phenotypes. Translational Oncology 2021, 15: 101256. PMID: 34717279, PMCID: PMC8564679, DOI: 10.1016/j.tranon.2021.101256.Peer-Reviewed Original ResearchSquamous cell carcinomaSquamous cell carcinoma casesLineage ACell carcinomaCervical squamous cell carcinomaE7 mRNA expressionHuman papillomavirus type 16Lineage A virusNon-malignant specimensAssociation of variantsDNA copy numberD lineageCytological outcomeHPV16 genomeEpisomal HPV16Sub-lineagesCopy numberIndian patientsA virusType 16Oncogenic phenotypeHPV16LineagesA1 virusesRisk allelesAssociation of clade-G SARS-CoV-2 viruses and age with increased mortality rates across 57 countries and India
Pandit B, Bhattacharjee S, Bhattacharjee B. Association of clade-G SARS-CoV-2 viruses and age with increased mortality rates across 57 countries and India. Infection Genetics And Evolution 2021, 90: 104734. PMID: 33508515, PMCID: PMC7839510, DOI: 10.1016/j.meegid.2021.104734.Peer-Reviewed Original ResearchConceptsIndication of population expansionNegative Tajima's D valuesAllele frequency spectrumTajima's D valuesSARS-CoV-2 sequencesAmino acid changesClade of virusesNucleotide diversityEvolutionary analysisLinkage disequilibriumPopulation expansionContribution of host factorsViral haplotypesClade GAcid changesSARS-CoV-2 variantsViral populationsHost factorsMortality rateVariantsViral factorsNetwork analysisCoronary heart diseaseSARS-CoV-2 virusVirus
2020
Prevalence of Colistin-Resistant, Carbapenem-Hydrolyzing Proteobacteria in Hospital Water Bodies and Out-Falls of West Bengal, India
Bardhan T, Chakraborty M, Bhattacharjee B. Prevalence of Colistin-Resistant, Carbapenem-Hydrolyzing Proteobacteria in Hospital Water Bodies and Out-Falls of West Bengal, India. International Journal Of Environmental Research And Public Health 2020, 17: 1007. PMID: 32033408, PMCID: PMC7037630, DOI: 10.3390/ijerph17031007.Peer-Reviewed Original ResearchConceptsColistin resistanceEosin methylene blue agarLevels of antibiotic resistanceNon-susceptible to meropenemPrevalence of colistin resistanceMethylene blue agarMeropenem-non-susceptiblePredominant speciesNon-susceptible isolatesCarbapenemase genesBlue agarAntibiotic resistanceMDR bacteriaNon-susceptibilityEnvironmental sourcesBacterial infectionsIsolatesGenesMeropenemHospitalSpeciesPrevalence patternsPrevalenceHospital wastewaterIndiscriminate use