Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsBenjamin Goldman-Israelow, MD, PhD
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Assistant Professor AdjunctDownloadHi-Res Photo
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Assistant Professor Adjunct
Biography
Dr. Benjamin Goldman-Israelow is an Assistant Professor in the Department of Internal Medicine in the section of Infectious Diseases. He obtained his AB in Biology from Washington University in St. Louis and his MD and PhD degrees from The Icahn School of Medicine at Mount Sinai. He joined Yale internal medicine in the ABIM Short Track Pathway, completing residency and Infectious Diseases fellowship training. During fellowship, Dr. Goldman-Israelow joined the laboratory of Dr. Akiko Iwasaki for his postdoctoral studies. There, he has studied SARS-CoV-2 infection, pathogenesis, and immunity in both patients and pre-clinical models. His work has led to the development of one of the first mouse models to study SARS-CoV-2, the identification of immunologic factors contributing to COVID-19 pathogenesis and protection, and the development of a novel mucosal vaccine strategy that protects against pathology and transmission.
Dr. Goldman-Israelow is a practicing infectious diseases physician and also conducts biomedical research. His lab is focused on understanding the development of mucosal immune memory to emerging and endemic respiratory pathogens. Working through the lenses of natural infection and vaccination, the Israelow lab aims to better understand the correlates of protection and transmission of pandemic-associated pathogens, and leverage this research to develop the next generation of mucosal vaccines and therapeutics.
Last Updated on May 28, 2025.
Departments & Organizations
- ABIM Physician-Scientist Research Pathway
- Center for Infection and Immunity
- Internal Medicine
- Janeway Society
- Virology Laboratories
- Yale Medicine
- Yale New Haven Health System
Education & Training
- Postdoctoral Fellow
- Yale School of Medicine (2022)
- Fellow
- Yale New Haven Hospital (2022)
- ABIM Physician-Scientist Research Pathway Resident
- Yale New Haven Hospital / Yale School of Medicine (2022)
- Resident
- Yale New Haven Hospital (2018)
- PhD
- Icahn School of Medicine at Mount Sinai, Microbiology (2016)
- MD
- Icahn School of Medicine at Mount Sinai, Microbiology (2016)
- AB
- Washington University in St. Louis, Biology (2006)
Research
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Overview
Medical Research Interests
Adaptive Immunity; Communicable Diseases, Emerging; Immunity, Cellular; Immunity, Humoral; Immunity, Innate; Immunity, Mucosal; Infections; Infectious Disease Medicine; Pandemics; SARS-CoV-2; Vaccine-Preventable Diseases; Vaccines; Vaccines, Attenuated; Vaccines, Synthetic; Vector Borne Diseases; Viral Vaccines; Virology; Virus Diseases; Zoonoses
Research at a Glance
Yale Co-Authors
Frequent collaborators of Benjamin Goldman-Israelow's published research.
Publications Timeline
A big-picture view of Benjamin Goldman-Israelow's research output by year.
Research Interests
Research topics Benjamin Goldman-Israelow is interested in exploring.
Akiko Iwasaki, PhD
Tianyang Mao
Former YSMAlbert Icksang Ko, MD
Nathan Grubaugh, PhD
Chantal Vogels, PhD
Anne Wyllie
Former YSM
32Publications
9,048Citations
SARS-CoV-2
Pandemics
Immunity, Innate
Immunity, Humoral
Immunity, Mucosal
Immunity, Cellular
Publications
Featured Publications
Unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses
Mao T, Israelow B, Peña-Hernández MA, Suberi A, Zhou L, Luyten S, Reschke M, Dong H, Homer RJ, Saltzman WM, Iwasaki A. Unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses. Science 2022, 378: eabo2523. PMID: 36302057, PMCID: PMC9798903, DOI: 10.1126/science.abo2523.Peer-Reviewed Original ResearchCitationsAltmetric
2022
Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation
Fernández-Castañeda A, Lu P, Geraghty AC, Song E, Lee MH, Wood J, O'Dea MR, Dutton S, Shamardani K, Nwangwu K, Mancusi R, Yalçın B, Taylor KR, Acosta-Alvarez L, Malacon K, Keough MB, Ni L, Woo PJ, Contreras-Esquivel D, Toland AMS, Gehlhausen JR, Klein J, Takahashi T, Silva J, Israelow B, Lucas C, Mao T, Peña-Hernández MA, Tabachnikova A, Homer RJ, Tabacof L, Tosto-Mancuso J, Breyman E, Kontorovich A, McCarthy D, Quezado M, Vogel H, Hefti MM, Perl DP, Liddelow S, Folkerth R, Putrino D, Nath A, Iwasaki A, Monje M. Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation. Cell 2022, 185: 2452-2468.e16. PMID: 35768006, PMCID: PMC9189143, DOI: 10.1016/j.cell.2022.06.008.Peer-Reviewed Original ResearchCitationsAltmetricInflammasome activation in infected macrophages drives COVID-19 pathology
Sefik E, Qu R, Junqueira C, Kaffe E, Mirza H, Zhao J, Brewer JR, Han A, Steach HR, Israelow B, Blackburn HN, Velazquez SE, Chen YG, Halene S, Iwasaki A, Meffre E, Nussenzweig M, Lieberman J, Wilen CB, Kluger Y, Flavell RA. Inflammasome activation in infected macrophages drives COVID-19 pathology. Nature 2022, 606: 585-593. PMID: 35483404, PMCID: PMC9288243, DOI: 10.1038/s41586-022-04802-1.Peer-Reviewed Original ResearchCitationsAltmetricMultiscale PHATE identifies multimodal signatures of COVID-19
Kuchroo M, Huang J, Wong P, Grenier JC, Shung D, Tong A, Lucas C, Klein J, Burkhardt DB, Gigante S, Godavarthi A, Rieck B, Israelow B, Simonov M, Mao T, Oh JE, Silva J, Takahashi T, Odio CD, Casanovas-Massana A, Fournier J, Farhadian S, Dela Cruz C, Ko A, Hirn M, Wilson F, Hussin J, Wolf G, Iwasaki A, Krishnaswamy S. Multiscale PHATE identifies multimodal signatures of COVID-19. Nature Biotechnology 2022, 40: 681-691. PMID: 35228707, PMCID: PMC10015653, DOI: 10.1038/s41587-021-01186-x.Peer-Reviewed Original ResearchCitationsAltmetricHigh-affinity, neutralizing antibodies to SARS-CoV-2 can be made without T follicular helper cells
Chen JS, Chow RD, Song E, Mao T, Israelow B, Kamath K, Bozekowski J, Haynes WA, Filler RB, Menasche BL, Wei J, Alfajaro MM, Song W, Peng L, Carter L, Weinstein JS, Gowthaman U, Chen S, Craft J, Shon JC, Iwasaki A, Wilen CB, Eisenbarth SC. High-affinity, neutralizing antibodies to SARS-CoV-2 can be made without T follicular helper cells. Science Immunology 2022, 7: eabl5652-eabl5652. PMID: 34914544, PMCID: PMC8977051, DOI: 10.1126/sciimmunol.abl5652.Peer-Reviewed Original ResearchCitationsAltmetric
2021
A humanized mouse model of chronic COVID-19
Sefik E, Israelow B, Mirza H, Zhao J, Qu R, Kaffe E, Song E, Halene S, Meffre E, Kluger Y, Nussenzweig M, Wilen CB, Iwasaki A, Flavell RA. A humanized mouse model of chronic COVID-19. Nature Biotechnology 2021, 40: 906-920. PMID: 34921308, PMCID: PMC9203605, DOI: 10.1038/s41587-021-01155-4.Peer-Reviewed Original ResearchCitationsAltmetricA stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice
Mao T, Israelow B, Lucas C, Vogels CBF, Gomez-Calvo ML, Fedorova O, Breban MI, Menasche BL, Dong H, Linehan M, Alpert T, Anderson F, Earnest R, Fauver J, Kalinich C, Munyenyembe K, Ott I, Petrone M, Rothman J, Watkins A, Wilen C, Landry M, Grubaugh N, Pyle A, Iwasaki A. A stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice. Journal Of Experimental Medicine 2021, 219: e20211818. PMID: 34757384, PMCID: PMC8590200, DOI: 10.1084/jem.20211818.Peer-Reviewed Original ResearchCitationsAltmetricLongitudinal Immune Profiling of a Severe Acute Respiratory Syndrome Coronavirus 2 Reinfection in a Solid Organ Transplant Recipient
Klein J, Brito AF, Trubin P, Lu P, Wong P, Alpert T, Peña-Hernández MA, Haynes W, Kamath K, Liu F, Vogels CBF, Fauver JR, Lucas C, Oh J, Mao T, Silva J, Wyllie AL, Muenker MC, Casanovas-Massana A, Moore AJ, Petrone ME, Kalinich CC, Dela Cruz C, Farhadian S, Ring A, Shon J, Ko AI, Grubaugh ND, Israelow B, Iwasaki A, Azar MM, Team F. Longitudinal Immune Profiling of a Severe Acute Respiratory Syndrome Coronavirus 2 Reinfection in a Solid Organ Transplant Recipient. Journal Of Infectious Diseases 2021, 225: 374-384. PMID: 34718647, PMCID: PMC8807168, DOI: 10.1093/infdis/jiab553.Peer-Reviewed Original ResearchCitationsAltmetricReply to: A finding of sex similarities rather than differences in COVID-19 outcomes
Takahashi T, Ellingson MK, Wong P, Israelow B, Lucas C, Klein J, Silva J, Mao T, Oh JE, Tokuyama M, Lu P, Venkataraman A, Park A, Liu F, Meir A, Sun J, Wang EY, Casanovas-Massana A, Wyllie AL, Vogels CBF, Earnest R, Lapidus S, Ott IM, Moore AJ, Shaw A, Fournier JB, Odio CD, Farhadian S, Dela Cruz C, Grubaugh ND, Schulz WL, Ring AM, Ko AI, Omer SB, Iwasaki A. Reply to: A finding of sex similarities rather than differences in COVID-19 outcomes. Nature 2021, 597: e10-e11. PMID: 34552250, DOI: 10.1038/s41586-021-03645-6.Commentaries, Editorials and LettersCitationsAltmetricAdaptive immune determinants of viral clearance and protection in mouse models of SARS-CoV-2
Israelow B, Mao T, Klein J, Song E, Menasche B, Omer SB, Iwasaki A. Adaptive immune determinants of viral clearance and protection in mouse models of SARS-CoV-2. Science Immunology 2021, 6: eabl4509-eabl4509. PMID: 34623900, PMCID: PMC9047536, DOI: 10.1126/sciimmunol.abl4509.Peer-Reviewed Original ResearchCitationsAltmetric
Academic Achievements & Community Involvement
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Honors
honor Young Physician-Scientist Award
05/12/2023National AwardAmerican Society for Clinical Investigation (ASCI) CouncilDetailsUnited Stateshonor Iva Dostanic, MD, PhD, Physician-Scientist Trainee Award
03/24/2022Yale School of Medicine AwardDepartment of Internal MedicineDetailsUnited Stateshonor Ruth L. Kirschstein National Research Service Award
06/01/2012National AwardNIAIDDetailsUnited States
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