About
Titles
Postdoctoral Fellow
Biography
Arthur Stem received his Ph.D. in Toxicology from the University of Colorado Anschutz Medical Campus. His dissertation centered on contributions of environmental toxicants to the pathogenesis of chronic kidney disease of unknown etiology. He joined the Vasilis lab in 2024 and is using his background in environmental and mechanistic toxicology to elucidate how environmental exposures influence the development of liver disease.
Last Updated on February 07, 2025.
Departments & Organizations
- All Institutions
Education & Training
- PhD
- University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Toxicology (2024)
- BS
- University of Arkansas at Little Rock, Biology (2014)
- AS
- National Park Community College, Science (2011)
Research
Publications
Featured Publications
Synergistic toxicity in alcohol-associated liver disease and PFAS exposure
Stem A, Tieghi R, Chatzi V, Kleinstreuer N, Valvi D, Thompson D, Vasiliou V. Synergistic toxicity in alcohol-associated liver disease and PFAS exposure. Toxicological Sciences 2025, 208: 9-31. PMID: 40737496, PMCID: PMC12599875, DOI: 10.1093/toxsci/kfaf110.Peer-Reviewed Original ResearchAlcohol-associated liver diseaseLiver diseaseChronic ethanol intakeCentral mechanismsHepatotoxic effectsPolyfluoroalkyl substancesHigh-risk populationOxidative stressDysregulated lipid metabolismEthanol intakeLiver functionLiver injuryAcetaldehyde-induced cytotoxicityHepatic functionHepatocellular damageOxidative stress inductionLiver pathologyGlobal morbidityPathogenic pathwaysPolyfluoroalkyl substances exposuresExposure to polyfluoroalkyl substancesFatty acid oxidationHealthcare accessEffects of polyfluoroalkyl substancesMultiple mechanisms
2026
WCN26-5042 Interaction of Sugacane Ash-Derived Silica Particles and Pesticides on Renal Cell Metabolism and the Thiol Redox Proteome
Chesterman C, Stem A, Roncal C, Johnson R, Brown J. WCN26-5042 Interaction of Sugacane Ash-Derived Silica Particles and Pesticides on Renal Cell Metabolism and the Thiol Redox Proteome. Kidney International Reports 2026, 11: 105744. DOI: 10.1016/j.ekir.2026.105744.Peer-Reviewed Original ResearchExposure to Per- and Polyfluoroalkyl Substances and Liver Cancer: A Systematic Review of Animal and Epidemiological Studies
Tanghal R, Beglarian E, Stem A, Aung M, Alderete T, Ducatman A, Vasiliou V, McConnell R, Conti D, Chatzi L. Exposure to Per- and Polyfluoroalkyl Substances and Liver Cancer: A Systematic Review of Animal and Epidemiological Studies. Environmental Science And Technology 2026, 60: 2816-2831. PMID: 41543329, PMCID: PMC12875370, DOI: 10.1021/acs.est.5c05535.Peer-Reviewed Original ResearchConceptsSystematic reviewLiver cancerMortality rates of liver cancerLifestyle risk factorsRate of liver cancerEpidemiological studiesLiver cancer riskPublic health policiesAnimal studiesMortality rateHuman epidemiologic findingsHepatocarcinogenic effectsHealth policyCancer riskLiver tumor incidenceReview of animalInclusion criteriaEpidemiological evidenceTumor incidenceProspective studyExposure to per-Liver toxicityPositive associationEnvironmental exposuresRisk factors
2025
Investigating the Quantitative Structure–Ionization Efficiency Relationship of Small Molecules and Lipids in the Presence of Ammonium Fluoride in MALDI-TIMS-QTOF Mass Spectrometry Imaging
Nikolopoulou V, Stem A, Vasiliou V, Aalizadeh R. Investigating the Quantitative Structure–Ionization Efficiency Relationship of Small Molecules and Lipids in the Presence of Ammonium Fluoride in MALDI-TIMS-QTOF Mass Spectrometry Imaging. Journal Of The American Society For Mass Spectrometry 2025, 36: 2460-2469. PMID: 41147643, DOI: 10.1021/jasms.5c00211.Peer-Reviewed Original ResearchConceptsIonization efficiencyAmmonium fluoridePresence of ammonium fluorideMass spectrometry imagingSmall moleculesIsotopically labeled metabolitesNegative polarity modeAnalysis of analytesEndogenous compoundsChemical structureIntermediate productsIonizationCompoundsMoleculesRelationship modelFluorideMALDIMetabolitesAnalytesComatrixQuantitationMatrixPolarization modesStructureDihydrochlorideIntegrating gut microbiome and neuroplasticity genomics in alcohol use disorder therapy
Koutromanos I, Legaki E, Dovrolis N, Vassilopoulos E, Stem A, Vasiliou V, Tzavellas E, Gazouli M. Integrating gut microbiome and neuroplasticity genomics in alcohol use disorder therapy. Human Genomics 2025, 19: 78. PMID: 40646629, PMCID: PMC12255058, DOI: 10.1186/s40246-025-00793-y.Peer-Reviewed Original ResearchConceptsGut microbiotaShort-chain fatty acid (SCFA)-producing bacteriaMetabolic pathwaysStress-related metabolic pathwaysHost-microbiota interactionsMicrobial metabolic pathwaysMulti-omics approachGut barrier integrityGene expression changesGene expression profilesNeuroplasticity-related genesRRNA sequencingGut microbiomeFamily genesGenomic signaturesMicrobiome compositionMicrobial compositionAUD patientsMicrobial dysbiosisTreatment responseFunctional pathwaysGene expressionMicrobiomeGenesExpression changesModulation of the thiol redox proteome by sugarcane ash-derived silica nanoparticles: Insights into chronic kidney disease of unknown etiology
Stem A, Michel C, Harris P, Rogers K, Gibb M, Roncal-Jimenez C, Reisdorph R, Johnson R, Roede J, Fritz K, Brown J. Modulation of the thiol redox proteome by sugarcane ash-derived silica nanoparticles: Insights into chronic kidney disease of unknown etiology. Free Radical Biology And Medicine 2025, 233: s44. DOI: 10.1016/j.freeradbiomed.2025.05.158.Peer-Reviewed Original ResearchAdvancing translational exposomics: bridging genome, exposome and personalized medicine
Sarigiannis D, Karakitsios S, Anesti O, Stem A, Valvi D, Sumner S, Chatzi L, Snyder M, Thompson D, Vasiliou V. Advancing translational exposomics: bridging genome, exposome and personalized medicine. Human Genomics 2025, 19: 48. PMID: 40307849, PMCID: PMC12044731, DOI: 10.1186/s40246-025-00761-6.Peer-Reviewed Original ResearchConceptsExposome-wide association studyBridge genomicsLifestyle exposuresEnhancing causal inferencePublic health decision-makingEnvironmental health researchHealth decision-makingMulti-omics technologiesGenomic variationGenomic dataAssociation studiesHealth outcomesBioinformatics approachHealth researchPrecision preventionGenetic variabilityExposome dataExposure-response relationshipMulti-OmicsGenomeInternal exposomeVulnerable populationsComplex diseasesDisease phenotypePublic healthModulation of the thiol redox proteome by sugarcane ash-derived silica nanoparticles: insights into chronic kidney disease of unknown etiology
Stem A, Michel C, Harris P, Rogers K, Gibb M, Roncal-Jimenez C, Reisdorph R, Johnson R, Roede J, Fritz K, Brown J. Modulation of the thiol redox proteome by sugarcane ash-derived silica nanoparticles: insights into chronic kidney disease of unknown etiology. Particle And Fibre Toxicology 2025, 22: 3. PMID: 39910563, PMCID: PMC11800628, DOI: 10.1186/s12989-025-00619-8.Peer-Reviewed Original ResearchMeSH KeywordsBasic Helix-Loop-Helix Transcription FactorsCell LineChronic Kidney Diseases of Uncertain EtiologyHumansKidney Tubules, ProximalNanoparticlesOccupational ExposureOxidation-ReductionOxidative StressProteomeProteomicsReactive Oxygen SpeciesReceptors, Aryl HydrocarbonRenal Insufficiency, ChronicSaccharumSilicon DioxideSulfhydryl CompoundsConceptsProximal convoluted tubulesActivation of aryl hydrocarbon receptorExposure to silica nanoparticlesDisease of unknown etiologyReactive oxygen speciesKidney proximal convoluted tubuleIncreased reactive oxygen species generationChronic kidney diseaseSignaling pathwayIntroductionChronic kidney diseaseHK-2 cellsReactive oxygen species generationProfile in vitroPotential mechanisms of toxicityMembrane hyperpolarizationCKD progressionUnknown etiologyGeneration of reactive oxygen speciesMitochondrial membrane hyperpolarizationOxygen species generationAryl hydrocarbon receptorEnergy metabolismKidney diseaseConvoluted tubulesMechanisms of toxicity
2024
Response to Avoid Preclinical Errors When Using Urine Biomarkers of Exposure
Stem A, Brindley S, Rogers K, Salih A, Roncal-Jimenez C, Johnson R, Newman L, Butler-Dawson J, Krisher L, Brown J. Response to Avoid Preclinical Errors When Using Urine Biomarkers of Exposure. Kidney International Reports 2024, 10: 281-283. PMID: 39810784, PMCID: PMC11725806, DOI: 10.1016/j.ekir.2024.11.003.Peer-Reviewed Original ResearchP06-05 Exposomics analysis of agricultural workers at risk for Mesoamerican nephropathy
Stem A, Roncal C, Johnson R, Brown J. P06-05 Exposomics analysis of agricultural workers at risk for Mesoamerican nephropathy. Toxicology Letters 2024, 399: s153. DOI: 10.1016/j.toxlet.2024.07.389.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
Get In Touch
Contacts
Email