Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsAntoni Duleba, MD
Professor (Adjunct) of Obstetrics, Gynecology, and Reproductive SciencesAbout
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Titles
Professor (Adjunct) of Obstetrics, Gynecology, and Reproductive Sciences
Education & Training
- MD
- University of British Columbia (1987)
Research
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Overview
Medical Research Interests
Dyslipidemias; Insulin; Obstetrics; Oxidative Stress; Polycystic Ovary Syndrome
ORCID
0000-0003-1419-6502
Research at a Glance
Research Interests
Research topics Antoni Duleba is interested in exploring.
Oxidative Stress
Polycystic Ovary Syndrome
Insulin
Publications
2024
Six-month randomized, placebo controlled trial of synbiotic supplementation in women with polycystic ovary syndrome undergoing lifestyle modifications
Chudzicka-Strugała I, Kubiak A, Banaszewska B, Wysocka E, Zwozdziak B, Siakowska M, Pawelczyk L, Duleba A. Six-month randomized, placebo controlled trial of synbiotic supplementation in women with polycystic ovary syndrome undergoing lifestyle modifications. Archives Of Gynecology And Obstetrics 2024, 311: 499-506. PMID: 39636391, PMCID: PMC11890239, DOI: 10.1007/s00404-024-07833-3.Peer-Reviewed Original ResearchCitationsAltmetricConceptsPolycystic ovary syndromeIntensive lifestyle modificationPlacebo groupLifestyle modificationSynbiotic groupMetabolic aspects of polycystic ovary syndromeSynbiotic supplementationImprovement of hyperandrogenismMarkers of endotoxemiaLow-density lipoprotein cholesterolPlacebo-controlled trialReduction of BMILong-term administrationBody fat percentageLPS-binding proteinAdministration of synbioticsObese subjectsReduced LHTotal testosteronePlaceboLipoprotein cholesterolLaboratory aspectsLipid profileTotal cholesterolSix-monthsLipopolysaccharide-induced chronic inflammation increases female serum gonadotropins and shifts the pituitary transcriptomic landscape
Garcia C, Velez L, Ujagar N, Del Mundo Z, Nguyen T, Fox C, Mark A, Fisch K, Lawson M, Duleba A, Seldin M, Nicholas D. Lipopolysaccharide-induced chronic inflammation increases female serum gonadotropins and shifts the pituitary transcriptomic landscape. Frontiers In Endocrinology 2024, 14: 1279878. PMID: 38260148, PMCID: PMC10801245, DOI: 10.3389/fendo.2023.1279878.Peer-Reviewed Original ResearchCitationsAltmetricConceptsChronic inflammationSerum gonadotropinChronic inflammatory stateFollicle stimulating hormoneAcute inflammatory stressFemale reproductive functionAcute LPSChronic LPSSerum luteinizingFSH secretionPituitary functionInflammatory stateWeekly injectionsGonadotropin productionHormone secretionInflammatory stressFemale miceLPS treatmentSex hormonesStimulating hormoneHormonal secretionChronic effectsParacrine activationReproductive functionInflammation
2004
Effects of oxidants and antioxidants on proliferation of endometrial stromal cells
Foyouzi N, Berkkanoglu M, Arici A, Kwintkiewicz J, Izquierdo D, Duleba AJ. Effects of oxidants and antioxidants on proliferation of endometrial stromal cells. Fertility And Sterility 2004, 82: 1019-1022. PMID: 15474067, DOI: 10.1016/j.fertnstert.2004.02.133.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsEndometrial stromal cellsVitamin E succinateStromal cellsOxidative stressHypoxanthine/xanthine oxidaseN-acetylcysteineModest oxidative stressXanthine oxidaseDose-dependent inhibitionDiphenyl tetrazolium bromide (MTT) assayDepletion of antioxidantsEndometrial stromaTetrazolium bromide assayReproductive ageMAIN OUTCOMEPathologic conditionsThymidine incorporationIncorporation assayMTT proliferationReactive oxygen speciesBromide assayDimethylthiazol-2EndometriosisComparable findingsProliferationMevastatin inhibits ovarian theca–interstitial cell proliferation and steroidogenesis
Izquierdo D, Foyouzi N, Kwintkiewicz J, Duleba AJ. Mevastatin inhibits ovarian theca–interstitial cell proliferation and steroidogenesis. Fertility And Sterility 2004, 82: 1193-1197. PMID: 15474095, DOI: 10.1016/j.fertnstert.2004.03.037.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPolycystic ovary syndromeTheca-interstitial cellsCardiovascular riskCultured theca-interstitial cellsVascular smooth muscle proliferationSmooth muscle proliferationPotential therapeutic agentConcentration-dependent inhibitionDiphenyl tetrazolium bromide (MTT) assayConcentration-dependent decreaseDNA synthesisMesenchymal hyperplasiaOvary syndromeTetrazolium bromide assayMuscle proliferationMAIN OUTCOMECulture protein contentSpecific radioimmunoassayEffects of mevastatinT productionTherapeutic agentsMTT proliferationBromide assayDimethylthiazol-2Cell proliferationProliferation of ovarian theca‐interstitial cells is modulated by antioxidants and oxidative stress
Duleba AJ, Foyouzi N, Karaca M, Pehlivan T, Kwintkiewicz J, Behrman HR. Proliferation of ovarian theca‐interstitial cells is modulated by antioxidants and oxidative stress. Human Reproduction 2004, 19: 1519-1524. PMID: 15178657, DOI: 10.1093/humrep/deh299.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsOxidative stressOvarian theca-interstitial cellsModest oxidative stressPathological conditionsPolycystic ovary syndromeI cellsTheca-interstitial cellsDose-dependent decreaseThecal-interstitial cellsXanthine oxidaseExcessive oxidative stressVitamin E succinateDepletion of antioxidantsMesenchymal hyperplasiaOvarian homeostasisOvary syndromeRat TGreater oxidative stressBiphasic effectIU/Inhibited proliferationSerum-free mediumThymidine incorporationReactive oxygen speciesOvarian mesenchymeMetformin therapy increases insulin-like growth factor binding protein-1 in hyperinsulinemic women with polycystic ovary syndrome
Pawelczyk L, Spaczynski RZ, Banaszewska B, Duleba AJ. Metformin therapy increases insulin-like growth factor binding protein-1 in hyperinsulinemic women with polycystic ovary syndrome. European Journal Of Obstetrics & Gynecology And Reproductive Biology 2004, 113: 209-213. PMID: 15063962, DOI: 10.1016/j.ejogrb.2003.09.031.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsPolycystic ovary syndromeQuantitative insulin sensitivity check indexInsulin-like growth factorMetformin therapyBody mass indexIGFBP-1Ovary syndromeHyperinsulinemic womenSerum levelsFree insulin-like growth factorTotal IGF-I levelsGlucose/insulin ratioInsulin sensitivity check indexGrowth factorHyperandrogenic PCOS womenIGFBP-1 concentrationsIGFBP-1 levelsFree testosterone indexIGF-I levelsEnd of therapyProtein 1PCOS womenTestosterone indexCompensatory hyperinsulinemiaMass index
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