Amr Elshahat
Associate Research Scientist in Radiology and Biomedical ImagingCards
About
Research
Publications
2025
Efficacy and safety of pregabalin and duloxetine in painful diabetic neuropathy: a systematic review and meta-analysis
Mansour A, Amin A, Gadelmawla A, Elbataa A, Mansour A, Elnady M, Husain M, Saad O, Elshahat A, Abbas A, Elshahat A, Mahmoud Y, Abdelsatar S, Elnaggar M, Fayk A, Elbanna A, Abd-Elsayed A. Efficacy and safety of pregabalin and duloxetine in painful diabetic neuropathy: a systematic review and meta-analysis. Pain Medicine 2025, pnaf155. PMID: 41212527, DOI: 10.1093/pm/pnaf155.Peer-Reviewed Original ResearchPainful diabetic neuropathySafety of pregabalinVisual analog scaleNumerical rating scaleVisual analog scale scorePain reductionAdverse eventsDiabetic neuropathyClinical managementMeta-analysisManagement of painful diabetic neuropathyPainful diabetic neuropathy patientsSF-12First-line medicationPatient-specific factorsRandom-effects meta-analysisMental componentComponent of SF-12No significant differenceEfficacy outcomesAnalog scaleSafety profileDecreased appetiteDuloxetineMental component of SF-12Effectiveness and safety of stiripentol in epilepsy: A systematic review and meta-analysis
Sabet H, Ramadan S, Ewis D, Zanaty M, El-Moslemani M, Elshahat A, Nasr A, Abbas A. Effectiveness and safety of stiripentol in epilepsy: A systematic review and meta-analysis. Brain Network Disorders 2025 DOI: 10.1016/j.bnd.2025.08.002.Peer-Reviewed Original ResearchStatus epilepticusAdverse eventsDravet syndromeSeizure freedomSeizure reductionDiscontinuation due to adverse eventsTreatment discontinuation due to adverse eventsClinical valueRates of seizure freedomEfficacy of stiripentolGeneralized tonic-clonic seizuresDifficult-to-treat epilepsyAtypical absence seizuresMeta-analysisGeneralized myoclonic seizuresTonic-clonic seizuresSystematic reviewEffective adjunctive treatmentRandom-effects modelRisk of biasWell-toleratedCase seriesJoanna Briggs Institute toolDecreased appetiteMyoclonic seizuresEffectiveness and safety of perampanel in Lennox-Gastaut syndrome: a GRADE-assessed systematic review and meta-analysis
Kumar D, Sabet H, Elshahat A, El-Moslemani M, Arafa A, Saleh M, Gamal S, Abbas A. Effectiveness and safety of perampanel in Lennox-Gastaut syndrome: a GRADE-assessed systematic review and meta-analysis. Naunyn-Schmiedeberg's Archives Of Pharmacology 2025, 398: 16521-16536. PMID: 40613940, DOI: 10.1007/s00210-025-04414-2.Peer-Reviewed Original ResearchLennox-Gastaut syndromeLennox-Gastaut syndrome patientsSafety of perampanelAdverse eventsBehavioral adverse eventsLennox-GastautAdjunctive therapySeizure freedomResponder rateDiscontinuation due to lackSystematic reviewPooled responder ratesIndividual risk-benefit evaluationConfidence intervalsSeizure freedom ratesPooled incidence rateComplete seizure freedomMeta-analysis aimComprehensive literature searchRandom-effects modelRisk-benefit evaluationChi-square testFreedom ratesWeb of ScienceSeizure aggravationAir Pollution and Dopamine in Parkinson’s Disease (S21.001)
Saraiya R, Cayir S, Pala V, Tezel M, Solomon B, Elshahat A, Matuskey D. Air Pollution and Dopamine in Parkinson’s Disease (S21.001). Neurology 2025, 104 DOI: 10.1212/wnl.0000000000208890.Peer-Reviewed Original ResearchAntiseizure Medications in Poststroke Seizures
Misra S, Wang S, Quinn T, Dawson J, Zelano J, Tanaka T, Grotta J, Khan E, Beriwal N, Funaro M, Perla S, Dev P, Larsson D, Hussain T, Liebeskind D, Yasuda C, Altalib H, Zaveri H, Elshahat A, Hitawala G, Wang E, Kitagawa R, Pathak A, Scalzo F, Ihara M, Sunnerhagen K, Walters M, Zhao Y, Jette N, Kasner S, Kwan P, Mishra N. Antiseizure Medications in Poststroke Seizures. Neurology 2025, 104: e210231. PMID: 39808752, DOI: 10.1212/wnl.0000000000210231.Peer-Reviewed Original ResearchConceptsRisk of biasLow-certainty evidenceModerate to high certainty evidenceNon-randomized Studies of Interventions toolDrug discontinuation ratesCochrane risk of bias toolRisk of bias toolAntiseizure medicationsSeizure recurrenceHigh risk of biasAdverse eventsCertainty of evidenceHigh-certainty evidencePoststroke seizuresModerate-certainty evidenceMortality rateRandomized Controlled TrialsDiscontinuation ratesAntiseizure medication useRecommendations AssessmentCochrane riskBias toolElectronic databasesNon-randomized studiesAssociated with high mortality rates
2024
Antiseizure Medications in Post-stroke Seizures: A Systematic Review and Network Meta-analysis (P8-1.012)
Misra S, Dawson J, Kwan P, Kasner S, Grotta J, Larsson D, Tanaka T, Zaveri H, Wang S, Khan E, Funaro M, Perla S, Dev P, Hussain T, Liebeskind D, Yasuda C, Elshahat A, Hitawala G, Wang E, Kitagawa R, Pathak A, Zhao Y, Scalzo F, Ihara M, Zelano J, Sunnerhagen K, Walters M, Jette N, Quinn T, Mishra N. Antiseizure Medications in Post-stroke Seizures: A Systematic Review and Network Meta-analysis (P8-1.012). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000205632.Peer-Reviewed Original Research