Voluntary Faculty
Voluntary faculty are typically clinicians or others who are employed outside of the School but make significant contributions to department programs at the medical center or at affiliate institutions.
Voluntary rank detailsSeth Lerner, MD
Assistant Clinical ProfessorAbout
Research
Publications
2026
Comparative analysis of patient-derived organoids and patient-derived xenografts as avatar models for predicting response to anti-cancer therapy
Romero J, Magrill J, Kalashnikov N, Luo Y, Chen O, Busque S, Ma R, Atallah A, Lazaratos A, Mendelson D, Wilson L, Deshmukh S, Taifour T, Sorin M, Arthur I, Kuasne H, Levett J, Wang Y, Seufferlein T, Kleger A, Gout J, Michels A, Brugarolas J, Poshusta Z, Hogenson T, Fernandez-Zapico M, Hamada A, Yagishita S, Kryeziu K, Lothe R, Nichols A, Barrett J, Papaccio F, Castillo J, Inoue M, Massfelder T, Lang H, Lindner V, Nilsson J, Dantes Z, Seppanen H, Wells G, Kim S, Ittmann M, Villanueva H, Lerner S, Sikora A, Theillet C, Huang D, Khuong-Quang D, Yeung J, Park M, Siegel P, Watson I, Zogopoulos G, Rose A, Dankner M. Comparative analysis of patient-derived organoids and patient-derived xenografts as avatar models for predicting response to anti-cancer therapy. Cancer Treatment Reviews 2026, 149: 103190. PMID: 42497819, DOI: 10.1016/j.ctrv.2026.103190.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsOncogenic PIK3CA reprograms glutamine metabolism to drive bladder cancer progression
Kami Reddy K, Putluri V, Piyarathna D, Park J, Arun A, Jorvekar S, Dou Y, Hassan M, Amara C, Kamal A, Ambati C, Xu J, Kraushaar D, Gramer A, Bellman A, Ballester L, Xu Y, Ripley R, Lerner S, Bollag R, Terris M, Pan C, Kaipparettu B, Lotan Y, Putluri N. Oncogenic PIK3CA reprograms glutamine metabolism to drive bladder cancer progression. Cell Communication And Signaling 2026 PMID: 42449388, DOI: 10.1186/s12964-026-03058-w.Peer-Reviewed Original ResearchProliferation- and cytotoxic immune signatures identify chemotherapy-responsive bladder tumors in a molecular subtype dependent manner
Zadoroznyj A, Eriksson P, Bernardo C, Tran L, Mattsson C, Flaig T, Seiler R, Tangen C, Black P, Lerner S, McConkey D, Höglund M, Liedberg F, Sjödahl G. Proliferation- and cytotoxic immune signatures identify chemotherapy-responsive bladder tumors in a molecular subtype dependent manner. Npj Precision Oncology 2026, 10: 258. PMID: 42399473, PMCID: PMC13332042, DOI: 10.1038/s41698-026-01588-7.Peer-Reviewed Original ResearchImmune-Enhancing Nutrition and Outcomes After Radical Cystectomy
Hamilton-Reeves J, Unger J, Holzbeierlein J, Lew D, Mark J, Daneshmand S, Lerner S, Kukreja J, Lee E, Tabayoyong W, Hershman D, Fisch M, Henry N. Immune-Enhancing Nutrition and Outcomes After Radical Cystectomy. JAMA Network Open 2026, 9: e2623622. PMID: 42475098, PMCID: PMC13386599, DOI: 10.1001/jamanetworkopen.2026.23622.Peer-Reviewed Original ResearchEarly Efficacy and Exploratory Biomarker Data of Bel-sar in Patients with Intermediate-risk and High-risk Non–muscle-invasive Bladder Cancer
Linehan J, Agarwal P, Penny X, Kates M, Jacob J, Lerner S, Kines R, Schiller J, de los Pinos E, Shore N, Hopkins J, McQuaid J, Brookman-May S. Early Efficacy and Exploratory Biomarker Data of Bel-sar in Patients with Intermediate-risk and High-risk Non–muscle-invasive Bladder Cancer. European Urology Open Science 2026, 89: 77-88. PMID: 42325814, PMCID: PMC13279200, DOI: 10.1016/j.euros.2026.05.017.Peer-Reviewed Original ResearchNarrative Review of Potential Non-Surgical Treatments for BCG-Unresponsive Non-Muscle Invasive Bladder Cancer
Kim S, Gudlavalleti H, Lerner S. Narrative Review of Potential Non-Surgical Treatments for BCG-Unresponsive Non-Muscle Invasive Bladder Cancer. Journal Of Clinical Medicine 2026, 15: 3830. PMID: 42194790, PMCID: PMC13208041, DOI: 10.3390/jcm15103830.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCigarette smoke induces FASN-dependent fatty acid metabolic rewiring to drive bladder cancer progression
Amara C, Piyarathna D, Kamal A, San Chan Y, Reddy K, Ambati C, Hassan M, Shriwas P, Gandhi T, Jain A, Gangnus T, Popli P, Borkar R, Kang S, Summers S, Putluri V, Grimm S, Venkatesh S, Song N, Seeley E, Hedlich-Dwyer J, Chen S, Mahajan N, Jain A, Dobrolecki L, Wells G, Villanueva H, Li J, Liu X, Bollag R, Malovannaya A, Jung S, Lee H, Asangani I, Terris M, Creighton C, Ballester L, Karanam B, Liu S, Lee M, Raju R, Siddiqui M, Eberlin L, Kommagani R, Sreekumar A, Gao J, Young N, Hodges H, Coarfa C, Gassman N, Lerner S, Lotan Y, Putluri N. Cigarette smoke induces FASN-dependent fatty acid metabolic rewiring to drive bladder cancer progression. Cancer Letters 2026, 653: 218562. PMID: 42092682, PMCID: PMC13241086, DOI: 10.1016/j.canlet.2026.218562.Peer-Reviewed Original ResearchLeveraging untargeted metabolomics in combination with machine learning to uncover novel insights into bladder cancer
Kamal A, Putluri V, Gandhi T, Ambati C, Amara C, Kami Reddy K, Spradlin M, Koirala A, Jorvekar S, Grimm S, Fu D, Parsawar K, Jong F, Beecher C, Sen S, Lerner S, Siddiqui M, Lotan Y, Eberlin L, Sreekumar A, Coarfa C, Putluri N. Leveraging untargeted metabolomics in combination with machine learning to uncover novel insights into bladder cancer. Cancer & Metabolism 2026, 14: 8. PMID: 41923172, PMCID: PMC13040883, DOI: 10.1186/s40170-026-00427-4.Peer-Reviewed Original ResearchRadiogenomic analysis of muscle-invasive bladder cancer using CT-based texture analysis
Boyne A, Anderson R, Liu D, Varghese B, Lei X, Hwang D, King K, Dani K, Cen S, Duddalwar V, Lerner S. Radiogenomic analysis of muscle-invasive bladder cancer using CT-based texture analysis. Bladder Cancer 2026, 12: 23523735261455396. PMID: 42221944, PMCID: PMC13219846, DOI: 10.1177/23523735261455396.Peer-Reviewed Original ResearchEnfortumab Vedotin plus Pembrolizumab as Perioperative Therapy
Singh P, Lerner S. Enfortumab Vedotin plus Pembrolizumab as Perioperative Therapy. The New England Journal Of Medicine 2026, 394: 1334-1336. PMID: 41707168, DOI: 10.1056/nejme2515777.Commentaries, Editorials and Letters