Gary Soffer, MD, FAAP
Associate Professor of Pediatrics (Pulmonary, Allergy, Immunology and Sleep Medicine)Cards
About
Research
Publications
2025
Update on the utilization of complementary therapies by adolescents with asthma in an urban population
Soffer G, Feinberg T, Kroll H, Reznik M. Update on the utilization of complementary therapies by adolescents with asthma in an urban population. Journal Of Asthma 2025, ahead-of-print: 1-9. PMID: 40040497, DOI: 10.1080/02770903.2025.2475451.Peer-Reviewed Original ResearchAsthma Control TestCAM useUtilization of complementary therapiesPrevalence of CAM usePrescription adherenceEfficacy of CAMHealth-promoting behaviorsPrimary care clinicsElectronic health recordsCAM utilizationCare clinicsActivity prescriptionHealth recordsAlternative medicineComplementary therapyAsthma managementLack of associationOutpatient specialtyAsthma controlSelf-reportAsthma severityLogistic regressionMind-bodyUrban adolescentsDemographic informationDecreased T helper 1 cell function underlies recurrent sinopulmonary infections in the 17q12 deletion syndrome
Shin J, Shin H, Gutierrez A, Yoo N, Par-Young J, Osmani L, Shin M, Sanchez-Lara P, Bucala R, Soffer G, Kang I. Decreased T helper 1 cell function underlies recurrent sinopulmonary infections in the 17q12 deletion syndrome. EBioMedicine 2025, 112: 105578. PMID: 39891996, PMCID: PMC11840234, DOI: 10.1016/j.ebiom.2025.105578.Peer-Reviewed Original ResearchConceptsCD4<sup>+</sup> T cellsRecurrent sinopulmonary infectionsT cell functionRNA-seq analysisT cellsHealthy controlsSinopulmonary infectionsRNA-seqT-betIFN-gFrequency of CD4<sup>+</sup> T cellsCD4<sup>+</sup> T cell functionTh1 transcription factor T-betDeletion syndromeFlow cytometryCompared to age-matched healthy controlsTranscription factor T-betDecreased T-betUrinary tract abnormalitiesAge-matched healthy controlsMultiplex assayDownstream effector cytokinesEffector cytokinesRecurrent infectionsTh17 cytokinesAlternative, Complementary, and Integrative Medicine Approaches to Allergic Rhinitis
Soffer G, Myers C, Weinstock M, Hand M. Alternative, Complementary, and Integrative Medicine Approaches to Allergic Rhinitis. Annals Of Allergy Asthma & Immunology 2025 PMID: 39870210, DOI: 10.1016/j.anai.2025.01.021.Peer-Reviewed Original Research
2024
Concordance of provider chart notation and guideline-based classification of asthma severity
Kroll H, Feinberg T, Soffer G, Reznik M. Concordance of provider chart notation and guideline-based classification of asthma severity. Journal Of Asthma 2024, 61: 1402-1411. PMID: 38717912, DOI: 10.1080/02770903.2024.2353106.Peer-Reviewed Original ResearchAsthma severity classificationChart notationUrban primary careClassification of asthma severityFair-to-goodWeighted kappa coefficientGuideline-based criteriaPrimary careNAEPP guidelinesDiagnosed asthmaConvenience sampleGuideline-basedAsthma criteriaPositive predictive valueAsthma severityAssess concordanceGuideline classificationPhysiciansEvaluate concordanceSeverity classificationClinic patientsPrescribed treatmentNAEPPMcNemar testKappa coefficientAppropriate Selection of Antihistamines in the Management of Allergic Reactions in the Pediatric Emergency Room: a quality improvement initiative
Tepler E, Mehta M, Tiyyagura G, Goldman M, Powers E, Soffer G. Appropriate Selection of Antihistamines in the Management of Allergic Reactions in the Pediatric Emergency Room: a quality improvement initiative. Journal Of Allergy And Clinical Immunology 2024, 153: ab54. DOI: 10.1016/j.jaci.2023.11.192.Peer-Reviewed Original Research
2023
SOMETHING'S FISHY WITH THE FEED: AN IGE-MEDIATED ALLERGIC REACTION TO HUMAN MILK
Halperin-Goldstein S, Soffer G. SOMETHING'S FISHY WITH THE FEED: AN IGE-MEDIATED ALLERGIC REACTION TO HUMAN MILK. Annals Of Allergy Asthma & Immunology 2023, 131: s170. DOI: 10.1016/j.anai.2023.08.523.Peer-Reviewed Original ResearchAssociated with allergen exposureHuman milkAllergic reactionsCase description ARare case reportFood proteinsSkin prick testAllergy to peanutIgE-mediated reactionsIgE-mediated allergic reactionsIntermittent pruritusBreastfed infantsCase reportRespiratory distressPrick testLaboratory evidenceChildren's dietsFood allergyMother's dietAllergen exposureComplementary foodsDiet modificationInduce sensitizationFin fishAllergic symptomatologyRacial, Ethnic, and Socioeconomic Differences in Food Allergies in the US
Jiang J, Warren C, Brewer A, Soffer G, Gupta R. Racial, Ethnic, and Socioeconomic Differences in Food Allergies in the US. JAMA Network Open 2023, 6: e2318162. PMID: 37314805, PMCID: PMC10267771, DOI: 10.1001/jamanetworkopen.2023.18162.Peer-Reviewed Original ResearchConceptsNon-Hispanic Black individualsNon-Hispanic white individualsParent-reported food allergyFood allergyWhite individualsBlack individualsEpinephrine autoinjector useFood allergy outcomesSurvey-weighted proportionsEmergency department visitsCommon food allergensFood allergy reactionsPopulation-based surveyCross-sectional survey studySimilar symptom presentationsLower ratesAutoinjector useDepartment visitsClinical outcomesPhysician diagnosisAllergy outcomesRepresentative sampleAllergy reactionsMAIN OUTCOMEPrevalence ratesThe emerging role of child life specialists in the pediatric food allergy clinic
Mathew M, Stahl U, Soffer G. The emerging role of child life specialists in the pediatric food allergy clinic. Annals Of Allergy Asthma & Immunology 2023, 131: 296-297. PMID: 37209837, DOI: 10.1016/j.anai.2023.05.013.Peer-Reviewed Original Research
2022
Computational analysis to define efficacy & molecular mechanisms of 7, 4’- Dihydroxyflavone on eosinophilic esophagitis: Ex-vivo validation in human esophagus biopsies
Maskey A, Wang Z, Chen X, Dunkin D, Yang N, Soffer G, Yuan Q, Li X. Computational analysis to define efficacy & molecular mechanisms of 7, 4’- Dihydroxyflavone on eosinophilic esophagitis: Ex-vivo validation in human esophagus biopsies. Frontiers In Immunology 2022, 13: 1015437. PMID: 36591238, PMCID: PMC9797535, DOI: 10.3389/fimmu.2022.1015437.Peer-Reviewed Original ResearchConceptsLevels of TNFIL-6Abdominal painEosinophilic esophagitisBiopsy samplesAbnormal bowel movementsTreatment of EoEMain treatment optionDihydroxy flavonesSignificant reductionTraditional Chinese medicine practiceDietary eliminationEoE therapyGE refluxSwallowed steroidsBowel movementsEoE patientsEsophageal dysfunctionGI symptomsEosinophilic inflammationImmunological mechanismsSteroid treatmentUpper endoscopyIgE productionChinese medicine practiceSafety Considerations for Natural Products Commonly Used By Patients with Allergic Disease
Soffer G, Shroff P, Horwitz R. Safety Considerations for Natural Products Commonly Used By Patients with Allergic Disease. The Journal Of Allergy And Clinical Immunology In Practice 2022, 10: 3131-3138. PMID: 36174919, DOI: 10.1016/j.jaip.2022.09.025.Peer-Reviewed Original ResearchConceptsConventional medical therapyHealth care providersMedical therapyAllergic diseasesClinical commentaryAdverse reactionsDrug Administration requirementsCare providersSide effectsAlternative medicinePatientsDietary supplementsU.S. FoodAllergyAdministration requirementsMedicinal plantsNatural productsTherapyCliniciansSafety considerationsDisease
Clinical Care
Overview
Gary Soffer, MD, is an allergist-immunologist who treats food and environmental allergies, asthma, hay fever, and eczema in children and adults.
Within the Integrative Medicine program at Smilow Cancer Hospital, Dr. Soffer provides cancer patients and survivors complementary therapies that complement, but do not replace, their standard cancer treatments. The program offers mind-body interventions, massage, and guidance on the safe use of herbal and dietary supplements.
“Allergy and integrative medicine are both areas that require the doctor to look at the whole patient and not just a single organ or disease,” he says. “My specialties allow me to get to know my patients and build long-lasting relationships.”
Any diagnosis can be difficult to navigate, he says. “I love working with my patients and their families to help guide them along their health journey.”
“My favorite part of the job is being with my amazing patients,” he says. “Whether this is seeing kids with food allergies, or adults with cancer, each patient has contributed to my life in a meaningful way.”
Clinical Specialties
Pediatric Allergy & Immunology
Fact Sheets
Penicillin Allergy
Learn More on Yale MedicineSeasonal Allergies (Allergic Rhinitis)
Learn More on Yale MedicineAlpha-gal Syndrome (AGS)
Learn More on Yale MedicineColds: How to Prevent Them
Learn More on Yale Medicine
Board Certifications
Allergy & Immunology
- Certification Organization
- AB of Allergy & Immunology
- Original Certification Date
- 2018
Yale Medicine News
News
News
- December 09, 2024Source: Healio
Meditation practice may positively influence allergy, immunology symptoms
- August 12, 2024Source: NBC Connecticut
Connecticut allergy community looks forward to newly FDA approved nasal spray
- July 08, 2024Source: Yale Medicine
Are You Getting Enough Vitamin B12? What You Need to Know
- June 19, 2024Source: NBC CT
The holistic healing program at Smilow Cancer Hospital
Get In Touch
Contacts
Appointment Number
Locations
Patient Care Locations
Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.