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Silvia Vilarinho, MD, PhD

Associate Professor of Medicine (Digestive Diseases) and of Pathology; Associate Director, Yale MD-PhD Program; Director, Internal Medicine Physician Scientist Training Program

Contact Information

Silvia Vilarinho, MD, PhD

Mailing Address

  • Yale School of Medicine

    Department of Medicine (Digestive Diseases), P.O. Box 208019

    New Haven, CT 06520-8019

    United States



Silvia Vilarinho is a physician-scientist who uses genetics, genomics and human samples to investigate the molecular basis of various liver diseases of unknown etiology. Using these approaches, we have identified five novel genetic liver diseases. Our research goal is to continue to discover new genes important in liver function both in health and disease and to use cell biology and animal models to determine the specific mechanism(s) linking mutant gene to disease as a roadmap to further understand and treat rare and common liver diseases.

This research approach provides new knowledge with direct impact in improving patient care and creates an outstanding scientific environment to train future physician-scientists and trainees with particular interest in human disease. Furthermore, I am very committed to make ‘genomic medicine for liver disease’ a reality in clinical practice worldwide.

Education & Training

  • Fellowship
    Yale University (2015)
  • Residency
    Yale University (2011)
  • Internship
    University of Minnesota (2010)
  • PhD
    University of Porto, Portugal (2008)
  • MD
    University of Porto (2004)

Honors & Recognition

AwardAwarding OrganizationDate
2023 Leah Lowenstein Award2023
Young Physician-Scientist AwardAmerican Society for Clinical Investigation2022
Inaugural John N. Forrest, Jr. Prize for Mentorship in Student Research2021
Doris Duke Clinical Scientist AwardDoris Duke Charitable Foundation2019
AASLD Sheila Sherlock Clinical and Translational Research AwardAASLD Foundation2015
Samuel Kushlan Award for Excellence in Research during Digestive Diseases Fellowship2015

Professional Service

American Association for the Study of Liver Disease (AASLD)AASLD Research Awards Committee2021 - Present
American Association for the Study of Liver Disease (AASLD)AASLD Basic Research Committee2021 - Present

Departments & Organizations