Chun Liang
Senior Research ScientistCards
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Research
Publications
2025
Promotion of a new gap junction gene Cx46 (GJA3) expression in the cochlea after Cx26 (GJB2) deficiency
Zhai T, Chen J, Kong Y, Liang C, Zhao H. Promotion of a new gap junction gene Cx46 (GJA3) expression in the cochlea after Cx26 (GJB2) deficiency. Hearing Research 2025, 468: 109454. PMID: 41115329, PMCID: PMC12645451, DOI: 10.1016/j.heares.2025.109454.Peer-Reviewed Original ResearchConceptsCx26 deficiencyCx46 expressionGene Set Enrichment AnalysisNonsyndromic hearing lossDigital droplet PCRCx26 expressionCx26 functionHearing lossCx46Cx26Gene mutationsHereditary deafnessImmunofluorescence stainingDroplet PCRCochleaPathological changesCx30GJA3Genetic changesQuantitative PCRDeficiencyChannel propertiesKnockoutGenes up-ExpressionATP-gated P2x7 receptors express at type II auditory nerves and required for efferent hearing control and noise protection
Liang C, Zhai T, Chen J, Fang S, Zhu Y, Liu L, Yu N, Zhao H. ATP-gated P2x7 receptors express at type II auditory nerves and required for efferent hearing control and noise protection. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2421995122. PMID: 40540593, PMCID: PMC12207453, DOI: 10.1073/pnas.2421995122.Peer-Reviewed Original ResearchConceptsCochlear efferent systemHearing sensitivityATP-gated P2X7 receptorP2X7 receptorOuter hair cellsAuditory nerveInnervate outer hair cellsEfferent systemAuditory brainstem responseSpiral ganglion (SGActive cochlear amplificationActive cochlear mechanicsEfferent nervesP2X7 KO miceIncreased susceptibility to noiseSusceptibility to noiseNeuronal functionAcoustic startle responseHair cellsBrainstem responseHearing lossEfferent suppressionHearing disordersOHC electromotilityNoise exposurePrevention and treatment of noise-induced hearing loss and cochlear synapse degeneration by potassium channel blockers in vivo
Zhao H, Liu L, Lu X, Quinonez A, Roberts R, Zhai T, Liang C. Prevention and treatment of noise-induced hearing loss and cochlear synapse degeneration by potassium channel blockers in vivo. Hearing Research 2025, 464: 109319. PMID: 40450915, PMCID: PMC12318480, DOI: 10.1016/j.heares.2025.109319.Peer-Reviewed Original ResearchNoise-induced hearing lossDistortion product otoacoustic emissionsAuditory brainstem responseNoise exposureHearing lossAcoustic startle responseTreatment of noise-induced hearing lossHidden hearing lossSystemic administrationInduce hearing lossGAL-021Active cochlear mechanicsChannel blockersOtoacoustic emissionsBrainstem responseHearing disordersAmeliorating noise-induced hearing lossCochlear mechanicsPost-exposure administrationSynapse degenerationInner hair cellsBK channelsAdministration timeIntraperitoneal injectionPharmacological treatment
2023
Atypical mismatch negativity during sleep in young children with autism spectrum disorder
Liang C, Zeng W, Zou C, Li B, Zhong S, Chen J. Atypical mismatch negativity during sleep in young children with autism spectrum disorder. Physiology 2023, 38: 5732036. DOI: 10.1152/physiol.2023.38.s1.5732036.Peer-Reviewed Original ResearchCx26 heterozygous mutations cause hyperacusis-like hearing oversensitivity and increase susceptibility to noise
Liu L, Liang C, Chen J, Fang S, Zhao H. Cx26 heterozygous mutations cause hyperacusis-like hearing oversensitivity and increase susceptibility to noise. Science Advances 2023, 9: eadf4144. PMID: 36753545, PMCID: PMC9908021, DOI: 10.1126/sciadv.adf4144.Peer-Reviewed Original ResearchConceptsActive cochlear amplificationCochlear amplificationHeterozygous mutationsPermanent hearing threshold shiftHearing threshold shiftCochlear lateral wallNonsyndromic hearing lossHearing lossMouse modelGeneral populationNoise exposureThreshold shiftHeterozygote carriersHearing sensitivityLateral wallJunction genesGap junction genesPotential generationUnexpected findingExposureMutationsOversensitivityProtein prestinDeafness
2021
Efferent neurons control hearing sensitivity and protect hearing from noise through the regulation of gap junctions between cochlear supporting cells
Zhao H, Liu L, Yu N, Zhu Y, Mei L, Chen J, Liang C. Efferent neurons control hearing sensitivity and protect hearing from noise through the regulation of gap junctions between cochlear supporting cells. Journal Of Neurophysiology 2021, 127: 313-327. PMID: 34907797, PMCID: PMC8759971, DOI: 10.1152/jn.00468.2021.Peer-Reviewed Original ResearchConceptsOuter hair cellsActive cochlear amplificationCochlear efferent systemDistortion product otoacoustic emissionsEfferent systemEfferent pathwaysHearing sensitivityMedial olivocochlear efferent fibersPresynaptic vesicular acetylcholine transportersGap junctionsOlivocochlear efferent fibersHair cellsApplication of acetylcholineCochlear supporting cellsProtection of hearingVesicular acetylcholine transporterActive cochlear amplifierCochlear amplificationPostsynaptic ACh receptorsProduct otoacoustic emissionsMOC efferent systemHair cell activityEfferent nervesEfferent inhibitionEfferent fibersDysfunction of the Auditory Brainstem as a Neurophysiology Subtype of Autism Spectrum Disorder
Chen J, Wei Z, Liang C, Liu B, Guo J, Kong X, Huang M, Peng Z, Wan G. Dysfunction of the Auditory Brainstem as a Neurophysiology Subtype of Autism Spectrum Disorder. Frontiers In Neuroscience 2021, 15: 637079. PMID: 33815042, PMCID: PMC8010248, DOI: 10.3389/fnins.2021.637079.Peer-Reviewed Original Research
2020
The Effect of Side of Implantation on the Cortical Processing of Frequency Changes in Adult Cochlear Implant Users
Liang C, Wenstrup L, Samy R, Xiang J, Zhang F. The Effect of Side of Implantation on the Cortical Processing of Frequency Changes in Adult Cochlear Implant Users. Frontiers In Neuroscience 2020, 14: 368. PMID: 32410947, PMCID: PMC7201306, DOI: 10.3389/fnins.2020.00368.Peer-Reviewed Original ResearchA Preliminary Study of the Effects of Attentive Music Listening on Cochlear Implant Users’ Speech Perception, Quality of Life, and Behavioral and Objective Measures of Frequency Change Detection
Firestone G, McGuire K, Liang C, Zhang N, Blankenship C, Xiang J, Zhang F. A Preliminary Study of the Effects of Attentive Music Listening on Cochlear Implant Users’ Speech Perception, Quality of Life, and Behavioral and Objective Measures of Frequency Change Detection. Frontiers In Human Neuroscience 2020, 14: 110. PMID: 32296318, PMCID: PMC7136537, DOI: 10.3389/fnhum.2020.00110.Peer-Reviewed Original ResearchFrequency change detection thresholdShort-term musical trainingCI usersCochlear implantationPsychoacoustic testsMusical trainingQualities of Hearing ScaleSpeech perceptionAdult CI usersSpeech recognition testsMusic training programPost-training testsQuality of lifeMagnitudes of frequency changesHearing ScaleHearing thresholdsHearing outcomesSSQ scoresPost-trainingComprehensive test batteryTraining programMusic listeningAudio cableFrequency change detectionTraining benefits
2019
Comparing musicians and non-musicians in signal-in-noise perception
Zhang F, Roland C, Rasul D, Cahn S, Liang C, Valencia G. Comparing musicians and non-musicians in signal-in-noise perception. International Journal Of Audiology 2019, 58: 717-723. PMID: 31187671, DOI: 10.1080/14992027.2019.1623424.Peer-Reviewed Original Research
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