Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsValerie A. Flores
Assistant Professor Adjunct of Obstetrics, Gynecology & Reproductive SciencesAbout
Research
Publications
2025
Use of AMD3100 for bone marrow–derived mesenchymal stem cell mobilization in the treatment of murine Asherman's syndrome
Flores V, Delis P, Mamillapalli R, Taylor H. Use of AMD3100 for bone marrow–derived mesenchymal stem cell mobilization in the treatment of murine Asherman's syndrome. F&S Science 2025, 6: 475-482. PMID: 40818715, DOI: 10.1016/j.xfss.2025.08.003.Peer-Reviewed Original ResearchAsherman's syndromePreterm ruptureAS inductionMurine modelProgenitor cellsMesenchymal stem cell mobilizationMice treated with AMD3100Preterm rupture of membranesAMD3100-treated miceRupture of membranesOptimal timingStem cell mobilizationBone marrow transplantationTreatment groupsLevels of CXCL12Source of progenitor cellsRecurrent pregnancy lossEndometrial progenitor cellsBMD-MSCsLikelihood of pregnancyHysteroscopic adhesiolysisPlacental abruptionUterine repairSevere ASMarrow transplantation
2024
Progesterone receptor status predicts aggressiveness of human endometriotic lesions in murine avatars
Flores V, Sahin C, Taylor H. Progesterone receptor status predicts aggressiveness of human endometriotic lesions in murine avatars. F&S Science 2024, 6: 65-72. PMID: 39393571, DOI: 10.1016/j.xfss.2024.10.004.Peer-Reviewed Original ResearchProgestin-based therapyAggressive forms of endometriosisPR lesionsProgesterone receptorGnRH antagonistMedroxyprogesterone acetatePR statusEndometriotic lesionsAggressive formResponse to MPAResponse to medical therapyPost-treatment sizeProgesterone receptor statusHuman endometriotic lesionsResponse to progestinsChronic gynecological diseaseDaily subcutaneous injectionsReproductive-age womenMouse xenograft modelResponse to medicationEndometrioma lesionsReceptor statusHormone suppressionPR expressionClinical responseFibroids and unexplained infertility treatment with epigallocatechin gallate: a natural compound in green tea (FRIEND) – protocol for a randomised placebo-controlled US multicentre clinical trial of EGCG to improve fertility in women with uterine fibroids
Al-Hendy A, Segars J, Taylor H, González F, Siblini H, Zamah M, Alkelani H, Singh B, Flores V, Christman G, Johnson J, Huang H, Zhang H. Fibroids and unexplained infertility treatment with epigallocatechin gallate: a natural compound in green tea (FRIEND) – protocol for a randomised placebo-controlled US multicentre clinical trial of EGCG to improve fertility in women with uterine fibroids. BMJ Open 2024, 14: e078989. PMID: 38216200, PMCID: PMC10806662, DOI: 10.1136/bmjopen-2023-078989.Peer-Reviewed Original ResearchConceptsUnexplained infertilityIntrauterine inseminationInstitutional review boardCumulative live birth rateUterine fibroidsLive birth rateCause of infertilityFood and Drug AdminstrationGonadotropin hormone-releasing hormoneGreen tea extractDouble-blind clinical trialNon-surgical treatment optionsTimed intrauterine inseminationUterine fibroid sizeOvarian stimulationQuality of Life Questionnaire scoresHormone-releasing hormoneLocal institutional review boardInfertility treatmentNational Institute of Child HealthInstitute of Child HealthMiscarriage rateBirth rateReproductive-age womenEndometrial quality
2023
Assessing the Hepatic Safety of Epigallocatechin Gallate (EGCG) in Reproductive-Aged Women
Siblini H, Al-Hendy A, Segars J, González F, Taylor H, Singh B, Flaminia A, Flores V, Christman G, Huang H, Johnson J, Zhang H. Assessing the Hepatic Safety of Epigallocatechin Gallate (EGCG) in Reproductive-Aged Women. Nutrients 2023, 15: 320. PMID: 36678191, PMCID: PMC9861948, DOI: 10.3390/nu15020320.Peer-Reviewed Original ResearchConceptsReproductive-aged womenLiver function testsUterine fibroidsUnexplained infertilityClomiphene citrateSerum liver function testsEpigallocatechin gallateSigns of drugSerum folate levelsGreen tea catechinsHepatic safetyPremenopausal womenProspective cohortDaily doseLiver injuryFunction testsTreatment armsLiver toxicityClinical studiesCommon causeFolate levelsEarly safety assessmentInterim analysisNormal rangeUse of EGCG
2022
Seven days of statin treatment improves nitric-oxide mediated endothelial-dependent cutaneous microvascular function in women with endometriosis
Dillon GA, Stanhewicz AE, Serviente C, Flores VA, Stachenfeld N, Alexander LM. Seven days of statin treatment improves nitric-oxide mediated endothelial-dependent cutaneous microvascular function in women with endometriosis. Microvascular Research 2022, 144: 104421. PMID: 35970408, PMCID: PMC9527706, DOI: 10.1016/j.mvr.2022.104421.Peer-Reviewed Original ResearchConceptsEndothelium-dependent vasodilationLaser Doppler fluxEndothelial functionCardiovascular diseaseOral atorvastatinExerts potent anti-inflammatory effectsEndothelium-dependent agonist acetylcholineShort-term statin administrationPotent anti-inflammatory effectsIntradermal microdialysis perfusionNO-dependent dilationImpaired endothelial functionMicrovascular endothelial functionCutaneous microvascular functionCutaneous vascular conductanceAnti-inflammatory effectsNO-dependent vasodilationNO synthase inhibitorDose-response curveStatin therapyAdjunctive therapyAtorvastatin treatmentCVD riskEndothelial dysfunctionStatin administrationPre-IVF treatment with a GnRH antagonist in women with endometriosis (PREGNANT): study protocol for a prospective, double-blind, placebo-controlled trial
Taylor H, Li HJ, Carson S, Flores V, Pal L, Robbins J, Santoro NF, Segars JH, Seifer D, Huang H, Young S, Zhang H. Pre-IVF treatment with a GnRH antagonist in women with endometriosis (PREGNANT): study protocol for a prospective, double-blind, placebo-controlled trial. BMJ Open 2022, 12: e052043. PMID: 35715184, PMCID: PMC9207753, DOI: 10.1136/bmjopen-2021-052043.Peer-Reviewed Original ResearchConceptsEndometriosis-associated infertilityPlacebo-controlled trialGnRH antagonistFertility treatmentOral GnRH antagonistEndometriosis-related infertilityFertilization-embryo transferLive birth rateUse of gonadotropinsEtiology of infertilityInstitutional review boardAntagonist pretreatmentCommon complicationObstetrical outcomesPeer-reviewed journalsSecondary outcomesIVF treatmentPrimary outcomeHormone agonistImplantation ratePregnancy rateLive birthsEndometriosisLocal protocolsOocyte number
2021
Chronic endometritis: A prevalent yet poorly understood entity
Margulies SL, Flores V, Parkash V, Pal L. Chronic endometritis: A prevalent yet poorly understood entity. International Journal Of Gynecology & Obstetrics 2021, 158: 194-200. PMID: 34605024, DOI: 10.1002/ijgo.13962.Peer-Reviewed Original ResearchConceptsChronic endometritisExact testCross-sectional observational studyEvidence-based consensusObstetrician/gynecologistsFisher's exact testSpectrum of deficienciesGood clinical practiceChi-square testAnonymous electronic surveyClinical presentationUnderappreciated burdenTreatment strategiesObservational studyPrevalent conditionDiagnostic criteriaEndometritisClinical practiceClinical implicationsSquare testEndometritis diagnosisConfidence intervalsHealthcare systemPrevalent inconsistenciesElectronic survey
2020
The Diagnostic Criteria for Chronic Endometritis: A Survey of Pathologists
Margulies SL, Dhingra I, Flores V, Hecht JL, Fadare O, Pal L, Parkash V. The Diagnostic Criteria for Chronic Endometritis: A Survey of Pathologists. International Journal Of Gynecological Pathology 2020, 40: 556-562. PMID: 33323860, DOI: 10.1097/pgp.0000000000000737.Peer-Reviewed Original ResearchConceptsChronic endometritisDiagnostic criteriaSurvey of pathologistsManagement of patientsSingle plasma cellsAnonymous electronic surveyActive inflammationHormonal stagesGynecologic pathologistsPathologic diagnosisAcute endometritisPlasma cellsGestational endometriumSpecial stainsEndometritisSubstantial variabilityDiagnosisPathologistsTreatment implicationsGreater likelihoodElectronic surveyEndometriumEtiological understandingInflammationPatientsAccurate Diagnosis of Endometriosis Using Serum MicroRNAs
Moustafa S, Burn M, Mamillapalli R, Nematian S, Flores V, Taylor H. Accurate Diagnosis of Endometriosis Using Serum MicroRNAs. Obstetrical & Gynecological Survey 2020, 75: 404-406. DOI: 10.1097/ogx.0000000000000816.Peer-Reviewed Original Research
2019
A step towards the automation of intracytoplasmic sperm injection: real time confirmation of mouse and human oocyte penetration and viability by electrical resistance measurement
Mor A, Zhang M, Esencan E, Simsek B, Nichols-Burns SM, Liu Y, Lo J, Kelk DA, Flores V, Gao XB, Seli E. A step towards the automation of intracytoplasmic sperm injection: real time confirmation of mouse and human oocyte penetration and viability by electrical resistance measurement. Fertility And Sterility 2019, 113: 234-236. PMID: 31883732, DOI: 10.1016/j.fertnstert.2019.09.023.Peer-Reviewed Original ResearchConceptsIntracytoplasmic sperm injectionICSI pipetteSperm injectionOocyte penetrationIntact oolemmaOocyte retrieval procedureMann-Whitney testMouse oocytesOocyte retrievalFemale miceMAIN OUTCOMEAcademic centersImmature oocytesHuman oocytesMature oocytesObjective toolMiceOocytesWomenVisual assessmentPipetteInjectionOolemmaStep 1Group