Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsRuth Asch
Assistant Professor Adjunct in PsychiatryAbout
Research
Publications
2026
337. Altered Brain Network Connectivity Mediates Links Between Poor Sleep, Depression Severity, and Suicidal Ideation in Mid-to-Late Life
Asch R, Cool R, Pietrzak R, Esterlis I. 337. Altered Brain Network Connectivity Mediates Links Between Poor Sleep, Depression Severity, and Suicidal Ideation in Mid-to-Late Life. Biological Psychiatry 2026, 99: s244. DOI: 10.1016/j.biopsych.2026.03.571.Peer-Reviewed Original ResearchMedication status is associated with metabotropic glutamate receptor 5 availability in bipolar disorder and with measures of attention, anhedonia, and cognition
Moisieienko K, Asch R, Davis M, DellaGioia N, Boster S, Pietrzak R, Esterlis I. Medication status is associated with metabotropic glutamate receptor 5 availability in bipolar disorder and with measures of attention, anhedonia, and cognition. Journal Of Affective Disorders 2026, 408: 121888. PMID: 42055136, DOI: 10.1016/j.jad.2026.121888.Peer-Reviewed Original ResearchNoninvasive Quantification of [18F]SynVesT-2 PET in Healthy Human Brains Using Simplified Reference Tissue Models
Hernández-Martín N, Balayeva T, Naganawa M, Asch R, Huang Y, Carson R, Gallezot J, Cai Z. Noninvasive Quantification of [18F]SynVesT-2 PET in Healthy Human Brains Using Simplified Reference Tissue Models. Journal Of Nuclear Medicine 2026, 67: 796-802. PMID: 41679926, PMCID: PMC13138105, DOI: 10.2967/jnumed.125.271207.Peer-Reviewed Original ResearchThis study investigates simplified models for measuring brain synaptic density using SV2A PET scans, showing a 40-minute scan can reliably replace invasive methods, improving clinical feasibility.
2025
In vivo evidence for metabotropic glutamate receptor 5 dysregulation in chronic pain
Davis M, Weiss E, DellaGioia N, Boster S, Asch R, Moisieienko K, Esterlis I. In vivo evidence for metabotropic glutamate receptor 5 dysregulation in chronic pain. Neuropsychopharmacology 2025, 51: 799-806. PMID: 41413678, PMCID: PMC12932697, DOI: 10.1038/s41386-025-02296-9.Peer-Reviewed Original ResearchNeural Signatures of Bipolar Disorder and Psychotropic Medication Effects: A Multimodal PET–MRI Study
Asch R, Fan S, Cool R, Boster S, DellaGioia N, Naganawa M, Nabulsi N, Lacadie C, Pietrzak R, Esterlis I. Neural Signatures of Bipolar Disorder and Psychotropic Medication Effects: A Multimodal PET–MRI Study. Biological Psychiatry 2025, s0006-3223(25)01664-6. PMID: 41325959, PMCID: PMC12981349, DOI: 10.1016/j.biopsych.2025.11.018.Peer-Reviewed Original ResearchIn Vivo Positron Emission Tomography Imaging of Presynaptic Density Reveals Stress-Associated Synaptic Deficits Related to Behavioral and Molecular Alterations in Rats
Asch R, Martin N, Garcia-Milian R, Fowles K, DiLeone R, Cai Z, Liston C, Esterlis I. In Vivo Positron Emission Tomography Imaging of Presynaptic Density Reveals Stress-Associated Synaptic Deficits Related to Behavioral and Molecular Alterations in Rats. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2025, 11: 463-475. PMID: 41038318, PMCID: PMC12614775, DOI: 10.1016/j.bpsc.2025.09.021.Peer-Reviewed Original ResearchExploring the influence of synaptic density and anxiety on pain perception: evidence from a [11C]UCB-J positron emission tomography imaging study
Moisieienko K, Asch R, Davis M, Pietrzak R, Esterlis I. Exploring the influence of synaptic density and anxiety on pain perception: evidence from a [11C]UCB-J positron emission tomography imaging study. The International Journal Of Neuropsychopharmacology 2025, 28: pyaf040. PMID: 40511849, PMCID: PMC12289550, DOI: 10.1093/ijnp/pyaf040.Peer-Reviewed Original ResearchEvaluation of radio-thin-layer chromatography as an alternative to radio-HPLC for [18F]SynVesT-1 metabolism analysis in rats
Balayeva T, Asch R, Tan P, Mennie W, Tong J, Chen B, Zhuang Z, Zheng C, Zheng M, Toyonaga T, Cai Z. Evaluation of radio-thin-layer chromatography as an alternative to radio-HPLC for [18F]SynVesT-1 metabolism analysis in rats. Nuclear Medicine And Biology 2025, 146: 109029. PMID: 40383020, PMCID: PMC12228526, DOI: 10.1016/j.nucmedbio.2025.109029.Peer-Reviewed Original ResearchVenous blood sampling for less invasive in vivo quantification of synaptic density with constant infusion of [18F]SynVesT-1 and PET
Asch R, Naganawa M, Moisieienko K, Weed M, Kapinos M, Zheng M, Hillmer A, Carson R, Pietrzak R, Esterlis I. Venous blood sampling for less invasive in vivo quantification of synaptic density with constant infusion of [18F]SynVesT-1 and PET. EJNMMI Research 2025, 15: 8. PMID: 39900828, PMCID: PMC11790547, DOI: 10.1186/s13550-025-01200-2.Peer-Reviewed Original Research
2024
An In Vivo Examination of the Relationship Between Metabotropic Glutamate 5 Receptor and Suicide Attempts in People With Borderline Personality Disorder
Davis M, Asch R, Weiss E, Wagner A, Fineberg S, Nabulsi N, Matuskey D, Carson R, Esterlis I. An In Vivo Examination of the Relationship Between Metabotropic Glutamate 5 Receptor and Suicide Attempts in People With Borderline Personality Disorder. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2024, 10: 324-332. PMID: 39613160, PMCID: PMC12009513, DOI: 10.1016/j.bpsc.2024.11.014.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
News
News
- December 16, 2025Source: Biological Psychiatry
Neural Signatures of Bipolar Disorder and Psychotropic Medication Effects: A Multimodal PET-MRI Study
- November 25, 2024
Yale Center for the Science of Cannabis and Cannabinoids Announces Inaugural Pilot Award Winners
- February 07, 2024
Asch Selected to Receive SOBP Travel Fellowship Award
- September 07, 2023
Asch Chosen to Receive YCCI Scholar Award
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