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Gretchen Hermes, MD, PhD

Associate Professor of Psychiatry

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Additional Titles

Medical Director, APT Foundation

Chief Psychiatrist, Yale Stress Center

Addiction Psychiatry Fellowship Coordinator, APT Foundation

About

Titles

Associate Professor of Psychiatry

Medical Director, APT Foundation; Chief Psychiatrist, Yale Stress Center; Addiction Psychiatry Fellowship Coordinator, APT Foundation

Biography

Gretchen Hermes, MD, PhD, MTS is a psychiatrist, psychoanalyst, researcher, and educator whose work explores the intersections of neuroscience, psychoanalysis, and theology in the understanding of trauma, addiction, and human vulnerability. Her scholarship and clinical work focus on how experiences of social disconnection, stress, and illness shape brain function, identity, and recovery across the lifespan.

Dr. Hermes earned her MD and PhD in neuroscience and human development from the University of Chicago, where she trained under the mentorship of Martha K. McClintock. She completed residency training in psychiatry at Yale School of Medicine, pursued psychoanalytic training at the Western New England Institute for Psychoanalysis, and holds a Master of Theological Studies from Harvard Divinity School.

Her early research used preclinical models to investigate how social isolation and disruptions in attachment influence stress physiology and disease vulnerability. This work established a scientific foundation for her subsequent clinical and scholarly focus on addiction, trauma, and the neurobiological consequences of relational loss. Dr. Hermes has published widely across neuroscience, psychiatry, and addiction studies and is currently editing a special issue of the Journal of the American Psychoanalytic Association devoted to addiction.

Dr. Hermes has held leadership roles in addiction treatment and psychiatric education, including serving as Medical Director at the APT Foundation and contributing to research and clinical work with the Yale Interdisciplinary Stress Center. She has taught and supervised medical students, residents, and fellows at Yale School of Medicine and has developed prison-based educational initiatives that use memoir writing to explore trauma, identity, and mental health.

She currently serves as Medical Director of Psychiatry at Gaylord Hospital, where she provides psychiatric consultation for patients with complex neurological, psychiatric, and medical conditions and collaborates with interdisciplinary rehabilitation teams. Her work at Gaylord is focused on developing a psychosocial recovery research program examining the interactions between trauma history, substance use, cognitive vulnerability, and rehabilitation outcomes.

Dr. Hermes is the founder of Reward Reimagined (rewardreimagined.org), a public initiative exploring addiction, reward, and human meaning. She is currently completing book-length projects that bring neuroscience, psychoanalysis, and theology into dialogue around a central question: how can psychiatry respond to suffering in ways that restore connection, meaning, and the possibility of belonging?

Last Updated on March 24, 2026.

Appointments

  • Psychiatry

    Associate Professor on Term
    Primary

Other Departments & Organizations

Education & Training

Research Fellowship, Schizophrenia
Yale University (2013)
Residency
Yale University (2011)
MD
University of Chicago Pritzker School of Medicine (2007)
Postdoctoral Fellowship, NIH, Interdisciplinary Program in Immunology
University of Chicago (2005)
PhD
University of Chicago (2003)
MA
Harvard Divinity School (1997)

Research

Overview

Dr. Hermes work at Gaylord is focused on developing a psychosocial recovery research program that examines the interactions among trauma history, substance use, cognitive vulnerability, and rehabilitation outcomes.

Dr. Hermes’s research trajectory spans preclinical models of stress and chronic disease, human studies of stress and addiction, and clinical trials in drug development for chronic mental illness. Across these domains, her work has centered on understanding how biological vulnerability and lived experience converge in the development and persistence of psychiatric illness.

Medical Research Interests

Psilocybin; Psychological Distress; Spirituality

Public Health Interests

Aging; Chronic Diseases; HIV/AIDS; Mental Health; Substance Use, Addiction

Research at a Glance

Yale Co-Authors

Frequent collaborators of Gretchen Hermes's published research.

Publications

2025

2024

Academic Achievements & Community Involvement

Activities

  • activity

    Ad Hoc Reviewer

  • activity

    California Breast Cancer Research Program; University of California, Office of the President

  • activity

    Female Opioid Research and Clinical Experts (FORCE)

Honors

  • honor

    NARSAD Young Investigator Grant

  • honor

    Workshop on Schizophrenia and Related Disorders, Travel Award and Stipend

  • honor

    Daniel X. and Mary Freedman Fellowship in Academic Psychiatry

  • honor

    APA-Pfizer M.D., Ph.D. Research Fellowship Award

  • honor

    Power Day Award, Psychiatry, for a resident nominated by 3rd year medical class, who serves as a true role model for Yale medical students

Clinical Care

Overview

Gretchen Hermes, MD, PhD, specializes in addiction psychiatry, providing care for individuals with addiction-related illnesses and co-occurring psychiatric diagnoses, including depression, anxiety, and psychotic spectrum illnesses.

Dr. Hermes emphasizes facilitating change and optimizing learning as chief psychiatrist at the Yale Stress Center. "If a therapy doesn't work, we will work together to find one that does," she says.

In her capacity as an associate professor of psychiatry at Yale School of Medicine, Dr. Hermes explores the effects of medications on drug craving and withdrawal, as well as the long-term impacts of early life trauma compared to acute stress. Dr. Hermes is also involved in studies on the role of certain proteins in mental illness, which could represent a shift in understanding the energy and biogenesis involved in these conditions.

Dr. Hermes received her medical degree from the University of Chicago Pritzker School of Medicine and completed her residency at Yale School of Medicine. She also completed post-doctoral work in infectious disease and psychoanalytic training at the Western New England Institute for Psychoanalysis.

Clinical Specialties

Psychiatry; Addiction Medicine

Board Certifications

  • Psychiatry

    Certification Organization
    AB of Psychiatry & Neurology
    Original Certification Date
    2025

Get In Touch

Contacts

Clinic Fax Number
Appointment Number
Mailing Address

Psychiatry

2 Church St S

New Haven, CT 06519

United States

Locations

  • Horvath Lab

    Lab

    Brady Memorial Laboratory

    310 Cedar Street, Ste 416

    New Haven, CT 06510

  • Yale Stress Center

    Academic Office

    Doctors Building

    2 Church Street South, Fl 2nd, Ste 208, Rm 209

    New Haven, CT 06519

  • Patient Care Locations

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