Nia Fogelman, PhD
Associate Research Scientist in PsychiatryCards
About
Research
Publications
2026
7. The Neurosteroid Pregnenolone Effects on Stress- And Cue- Provoked Alcohol Craving Associations With Drinking Outcomes in Individuals With Alcohol Use Disorder
Sakmar E, Wemm S, Fogelman N, Sinha R, Milivojevic V. 7. The Neurosteroid Pregnenolone Effects on Stress- And Cue- Provoked Alcohol Craving Associations With Drinking Outcomes in Individuals With Alcohol Use Disorder. Biological Psychiatry 2026, 99: s102. DOI: 10.1016/j.biopsych.2026.03.241.Peer-Reviewed Original Research381. Effects of Daily 8-WEEK Exogenous Pregnenolone Treatment on Downstream Metabolite Levels in Individuals With Alcohol Use Disorder
Milivojevic V, Fogelman N, Sinha R. 381. Effects of Daily 8-WEEK Exogenous Pregnenolone Treatment on Downstream Metabolite Levels in Individuals With Alcohol Use Disorder. Biological Psychiatry 2026, 99: s263. DOI: 10.1016/j.biopsych.2026.03.615.Peer-Reviewed Original ResearchMindfulness Intervention for Parent Stress and Childhood Obesity Risk: A Randomized Trial
Fogelman N, Bernstein H, Bautista T, Savoye M, Chaplin T, Silverman W, Jastreboff A, Sinha R. Mindfulness Intervention for Parent Stress and Childhood Obesity Risk: A Randomized Trial. PEDIATRICS 2026, 157: e2025072230. PMID: 41786283, PMCID: PMC12989181, DOI: 10.1542/peds.2025-072230.Peer-Reviewed Original ResearchChildhood obesity riskEarly childhood obesity riskChildren's food intakeHealthy food intakeObesity riskParenting stressChild BMI z-scoreSignificant time main effectPositive parentingTime main effectsBMI z-scoreWeekly group interventionFood intakeAssessment of long-term effectsRandomized Controlled TrialsPhysical activityChild BMIGroup interventionHealthy nutritionSecondary outcomesMindfulness interventionEarly childhood risksCoprimary outcomesChildhood riskInterventionAssociations Among Stressful Events, Social Support, and Alcohol Use in Women and Men
Hovnanyan A, Sinha R, Fogelman N. Associations Among Stressful Events, Social Support, and Alcohol Use in Women and Men. Behavioral Sciences 2026, 16: 261. PMID: 41750070, PMCID: PMC12938169, DOI: 10.3390/bs16020261.Peer-Reviewed Original ResearchAlcohol Use Disorders Identification TestAlcohol Use Disorders Identification Test scoresAlcohol use severityStressful eventsSocial supportAlcohol useImpact alcohol useStressful life eventsRisk of alcohol misuseDisorders Identification TestAmount of alcohol consumptionLonger stress durationsLife eventsAlcohol riskRecent stressAlcohol misuseIdentification TestSS scoresSocial interactionAlcohol consumptionAlcohol intakeStress durationAlcoholStressorsAdult womenSafety, tolerability, and drug-drug interactions of NYX-783 and oxycodone in persons using opioids recreationally: Preliminary results from a randomized, double-blind, placebo-controlled phase 1 study
Harvanek Z, Mignosa M, Kitaneh R, Oliva H, Borelli A, Dauginikas E, Fogelman N, Sakmar E, Taylor J, DiLeone R, Sinha R, Angarita G. Safety, tolerability, and drug-drug interactions of NYX-783 and oxycodone in persons using opioids recreationally: Preliminary results from a randomized, double-blind, placebo-controlled phase 1 study. Drug And Alcohol Dependence 2026, 279: 113041. PMID: 41604752, PMCID: PMC12924154, DOI: 10.1016/j.drugalcdep.2026.113041.Peer-Reviewed Original ResearchConceptsDrug-drug interactionsOpioid use disorderDouble-blindAdverse eventsDrug effectsSubjective drug effectsPlacebo-controlled phase 1 studyPositive allosteric modulatorsPhase 1 studyDiastolic blood pressureUse disorderOxycodone dosePrimary endpointInpatient studyOpioid useSynaptic plasticityPlasma levelsContext of opioid useOxycodoneAllosteric modulatorsPupillary dilationBlood pressureNovel treatmentRespiratory safetyHealthy humans
2025
Assessing Autonomic Regulation Under Stress with the Yale Pain Stress Test in Social Drinking and Alcohol Use Disorder
Barreto S, McGowan C, Fogelman N, Sinha R, Wemm S. Assessing Autonomic Regulation Under Stress with the Yale Pain Stress Test in Social Drinking and Alcohol Use Disorder. Behavioral Sciences 2025, 15: 1732. PMID: 41464075, PMCID: PMC12729474, DOI: 10.3390/bs15121732.Peer-Reviewed Original ResearchAlcohol use disorderUse disorderSocial drinkingSocial drinking controlsHeart rate variability recoveryPredictor of chronic illnessPre-stress baselineCold pressor testDSM-5 criteriaHeart rate variabilitySubstance use disordersEffects of stressAcute stress responseDSM-5New Haven areaAutonomic reactivityDrinking controlsAutonomic flexibilityStress exposureLevels of stressStress-related chronic diseasesChronic illnessTime-period effectsClinical careRepeated trialsDevelopment of the Yale pain stress test to elicit a multi-level stress response and assess stress adaptability
Fogelman N, Barreto S, McGowan C, Wemm S, Sinha R. Development of the Yale pain stress test to elicit a multi-level stress response and assess stress adaptability. Psychopharmacology 2025, 243: 1015-1028. PMID: 41361589, PMCID: PMC13242427, DOI: 10.1007/s00213-025-06972-y.Peer-Reviewed Original ResearchCold pressor taskPredictor of chronic illnessPain tolerancePre-stress baselineAcute physiological stress responseStress-related illnessesAcute stress responseLevels of stressPain stressStress responseResilient copingWithin-subject experimentPhysiological stress responseHealthy copingBasal anxietyChronic illnessSubjective distressHigher DBPHigher SBPSubjective stressGreater reactivityLower painStress testPain ratingsComponents of resiliencePregnenolone reduces provoked craving and cocaine use in men and women with cocaine use disorder: A pilot trial
Sakmar E, Wemm S, Fogelman N, Hermes G, Sinha R, Milivojevic V. Pregnenolone reduces provoked craving and cocaine use in men and women with cocaine use disorder: A pilot trial. Drug And Alcohol Dependence 2025, 274: 112765. PMID: 40570771, PMCID: PMC12264926, DOI: 10.1016/j.drugalcdep.2025.112765.Peer-Reviewed Original ResearchCocaine use disorderCocaine useNeuroactive steroidsUse disorderTreatment of cocaine use disorderCocaine use outcomePregnenolone levelsTreatment-seeking individualsDays of cocaineChronic cocaine useExposure to stressPreg groupCocaine cuesCocaine cravingCraving responsesNeutral cuesInduce cravingCravingWeek 2CocaineChronic treatmentPilot findingsCocaine amountPrecursor pregnenoloneLinear mixed effects modelsNeuroendocrine responses and coupling to laboratory-induced stress in problem gambling and heavy smoking
Wemm S, Holzhauer C, Harrison L, Milivojevic V, Fogelman N, Cao Z, Wulfert E. Neuroendocrine responses and coupling to laboratory-induced stress in problem gambling and heavy smoking. Psychoneuroendocrinology 2025, 177: 107469. PMID: 40250213, PMCID: PMC12131328, DOI: 10.1016/j.psyneuen.2025.107469.Peer-Reviewed Original ResearchConceptsTrier Social Stress TestHypothalamic-pituitary-adrenal axisAxis responseProblem gamblingPathophysiology of addictive disordersHPA axis responseSocial Stress TestHypothalamic-pituitary-gonadal axisHealthy control participantsLaboratory-induced stressStress-related changesStress hormone cortisolHypothalamic-pituitary-gonadal axis hormonesAddictive disordersAddiction mechanismsLaboratory stressorSubstance addictionControl participantsNeuroactive steroidsNeuroendocrine responsesAttenuated cortisolPsychological featuresProblem gamblersHormone cortisolGambling
2024
Stability and Reliability of Repeated Plasma Pregnenolone Levels After Oral Pregnenolone Dosing in Individuals with Cocaine Use Disorder: Pilot Findings
Gao H, Magin Z, Fogelman N, Sinha R, Angarita G, Milivojevic V. Stability and Reliability of Repeated Plasma Pregnenolone Levels After Oral Pregnenolone Dosing in Individuals with Cocaine Use Disorder: Pilot Findings. Life 2024, 14: 1483. PMID: 39598281, PMCID: PMC11595496, DOI: 10.3390/life14111483.Peer-Reviewed Original Researchcocaine use disordersubstance use disordersuse disorderpregnenolone levelstreatment of cocaine use disorderreduce alcohol cravingtreatment-seeking individualsassociated across timeadministration of pregnenoloneeight-week trialsignificant main effectalcohol cravingpregnenolone administrationnegative health risksdouble-blind clinical trialmain effectpilot findingslevels of pregnenolonechronic dosingstudy medication dosemedication dosesdisorderscocainepilot studystress biology
News
News
- June 05, 2026Source: Drug and Alcohol Dependence
Pilot Trial: Pregnenolone Reduces Provoked Craving and Cocaine Use in Men and Women with Cocaine Use Disorder
- March 22, 2023Source: New York Times
The Truth About the Internet’s Favorite Stress Hormone
- March 08, 2023Source: Journal of Psychiatric Research
Yale Study: Regular Cannabis Use is Associated With History of Childhood and Lifetime Trauma