Katrin Preller
Assistant Professor Adjunct, PsychiatryCards
About
Research
Publications
2025
A Field-Wide Review and Analysis of Study Materials Used in Psilocybin Trials: Assessment of Two Decades of Research
Yaden D, Graziosi M, Owen A, Agin-Liebes G, Aaronson S, Allen K, Barrett F, Bogenschutz M, Carhart-Harris R, Ching T, Cosimano M, Danforth A, Davis A, Garcia-Romeu A, Griffiths R, Grob C, Gründer G, Gukasyan N, Heinzerling K, Hendricks P, Holze F, Horton D, Johnson M, Kelmendi B, Peck S, Koslowski M, Liechti M, Mertens L, Moreno F, Nayak S, Nicholas C, Preller K, Rieser N, Ross S, Sergi K, Sloshower J, Smigielski L, Stenbæk D, Vollenweider F, Weiss B, Wolff M, Yaden M. A Field-Wide Review and Analysis of Study Materials Used in Psilocybin Trials: Assessment of Two Decades of Research. Psychedelic Medicine 2025 DOI: 10.1089/psymed.2024.0019.Peer-Reviewed Original Research
2024
Synergistic, multi-level understanding of psychedelics: three systematic reviews and meta-analyses of their pharmacology, neuroimaging and phenomenology
Shinozuka K, Jerotic K, Mediano P, Zhao A, Preller K, Carhart-Harris R, Kringelbach M. Synergistic, multi-level understanding of psychedelics: three systematic reviews and meta-analyses of their pharmacology, neuroimaging and phenomenology. Translational Psychiatry 2024, 14: 485. PMID: 39632810, PMCID: PMC11618481, DOI: 10.1038/s41398-024-03187-1.Peer-Reviewed Original ResearchConceptsFunctional connectivityBetween-network functional connectivityLevels of analysisWithin-network FCBetween-drug differencesMeta-analysesD2 receptorsPsychedelic effectsSerotonergic psychedelicsNeuroimaging resultsNeuropsychiatric disordersStates of consciousnessPsychedelicsNeural fingerprintsAltered statesNeuroimagingPsilocybinHigh dosesLSDSignificantly higher ratesMolecular pharmacologySystematic reviewAddictionDepressionPhenomenologyReconsidering evidence for psychedelic-induced psychosis: an overview of reviews, a systematic review, and meta-analysis of human studies
Sabé M, Sulstarova A, Glangetas A, De Pieri M, Mallet L, Curtis L, Richard-Lepouriel H, Penzenstadler L, Seragnoli F, Thorens G, Zullino D, Preller K, Böge K, Leucht S, Correll C, Solmi M, Kaiser S, Kirschner M. Reconsidering evidence for psychedelic-induced psychosis: an overview of reviews, a systematic review, and meta-analysis of human studies. Molecular Psychiatry 2024, 1-33. PMID: 39592825, DOI: 10.1038/s41380-024-02800-5.Peer-Reviewed Original ResearchRandomized-controlled trialsTreatment-resistant depressionEfficacy of psychedelicsPsychedelic-assisted therapyMeta-analysis of human studiesMeta-analytic dataOverview of reviewsMeta-analysisPre-registered protocolSystematic reviewNegative symptomsWorsen psychosisPsychotic symptomsPsychotic disordersSchizophreniaPsychosisCase-control studySymptom exacerbationPsychosis incidenceRandom-effects modelReview evidenceStandardized assessmentAssessment of study qualityCohort studyClinical trialsCorrection: Neural mechanisms of psychedelic visual imagery
Stoliker D, Preller K, Novelli L, Anticevic A, Egan G, Vollenweider F, Razi A. Correction: Neural mechanisms of psychedelic visual imagery. Molecular Psychiatry 2024, 1-1. PMID: 39572725, DOI: 10.1038/s41380-024-02818-9.Peer-Reviewed Original ResearchNew trends in the empirical study of consciousness: Measures and mechanisms
Tzovara A, Andrillon T, Preller K, Sarasso S. New trends in the empirical study of consciousness: Measures and mechanisms. European Journal Of Neuroscience 2024, 60: 6959-6961. PMID: 39558664, DOI: 10.1111/ejn.16606.Peer-Reviewed Original ResearchNeurobiological Correlates of Psychedelic Experiences and Psychedelic-Associated Adverse Effects
Rieser N, Schmidt T, Preller K. Neurobiological Correlates of Psychedelic Experiences and Psychedelic-Associated Adverse Effects. Current Topics In Behavioral Neurosciences 2024, 1-20. PMID: 39080245, DOI: 10.1007/7854_2024_507.Peer-Reviewed Original ResearchCortico-striato-thalamo-corticalPsychedelic experiencePathophysiology of psychiatric illnessPsychedelic drug actionEffects of psychedelicsHuman neuroimaging studiesAcute drug effectsEffects of psychedelic drugsEntropic brain hypothesisNeurobiological correlatesEgo dissolutionNeural correlatesNeurobiological mechanismsNeuroimaging studiesNeural mechanismsPsychiatric illnessPsychedelic drugsBrain hypothesisDrug effectsPET measurementsSubacute adverse effectsDrug actionGeneral effectEmotional impactLong-term adverse effectsNeural mechanisms of psychedelic visual imagery
Stoliker D, Preller K, Novelli L, Anticevic A, Egan G, Vollenweider F, Razi A. Neural mechanisms of psychedelic visual imagery. Molecular Psychiatry 2024, 1-8. PMID: 38862674, DOI: 10.1038/s41380-024-02632-3.Peer-Reviewed Original ResearchVisual association regionsVisual imageryConsistent with preclinical findingsInferior frontal gyrusSerotonergic psychedelic drugTop-down feedback connectionsFunctional MRI scansVisual areasDynamic causal modelingEffective connectivity modelsTop-down connectionsEarly visual areasFusiform gyrusFrontal gyrusClassic psychedelicsIntraparietal sulcusBehavioral measuresNeural mechanismsPsychedelic experiencePsychedelic drugsConnectivity changesAffect balancePlacebo-controlledPreclinical findingsCausal modelThe influence of psilocybin on subconscious and conscious emotional learning
Casanova A, Ort A, Smallridge J, Preller K, Seifritz E, Vollenweider F. The influence of psilocybin on subconscious and conscious emotional learning. IScience 2024, 27: 110034. PMID: 38883812, PMCID: PMC11177198, DOI: 10.1016/j.isci.2024.110034.Peer-Reviewed Original ResearchPsychedelic-assisted psychotherapyAgonist psilocybinFearful facesNeutral cuesEmotional cuesPsychiatric disordersSerotonergic psychedelicsSerotonin signalingExploratory behaviorPsilocybinEmotional learningLearning effectCuesPlacebo groupPlaceboPsychotherapyLearning rateLearningPsychedelicsSerotoninReinforcement learningDisordersTreatment modalitiesBrainTaskPsychedelics in Medicine: Can Evidence Keep Up With Enthusiasm?
de Wit H, Holze F, Preller K. Psychedelics in Medicine: Can Evidence Keep Up With Enthusiasm? Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2024, 9: 460-461. PMID: 38719373, DOI: 10.1016/j.bpsc.2024.02.010.Peer-Reviewed Original ResearchKetamine induces multiple individually distinct whole-brain functional connectivity signatures
Moujaes F, Ji J, Rahmati M, Burt J, Schleifer C, Adkinson B, Savic A, Santamauro N, Tamayo Z, Diehl C, Kolobaric A, Flynn M, Rieser N, Fonteneau C, Camarro T, Xu J, Cho Y, Repovs G, Fineberg S, Morgan P, Seifritz E, Vollenweider F, Krystal J, Murray J, Preller K, Anticevic A. Ketamine induces multiple individually distinct whole-brain functional connectivity signatures. ELife 2024, 13: e84173. PMID: 38629811, PMCID: PMC11023699, DOI: 10.7554/elife.84173.Peer-Reviewed Original ResearchConceptsResponse to ketamineAcute ketamineBehavioral effectsQuantified resting-state functional connectivityEffects of acute ketamineSymptom variationResting-state functional connectivityTreatment-resistant depressionFunctional connectivity signaturesGlobal brain connectivitySingle-subject levelInter-individual variabilityPlacebo-controlled studyFunctional connectivityConnectivity signaturesBrain connectivityHealthy participantsSingle-blind placebo-controlled studyNeural variationsTreatment conditionsKetamineGene expression targetsPharmacological biomarkersPilot awardParvalbumin