Cat McCann, PhD

they/them/theirs

Academic Coordinator and Registrar

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Contact Info

cat.mccann@yale.edu

Pharmacology

333 Cedar St, SHM B 208B

New Haven, CT 06511

United States

Education

PhD
Johns Hopkins University School of Medicine, Cellular and Molecular Physiology (2021)

BSc
Worcester Polytechnic Institute, Biochemistry (2013)

About

Titles

Academic Coordinator and Registrar

Departments & Organizations

Pharmacology

Education & Training

PhD: Johns Hopkins University School of Medicine, Cellular and Molecular Physiology (2021)

BSc: Worcester Polytechnic Institute, Biochemistry (2013)

Research

Research at a Glance

Publications Timeline

A big-picture view of Cat McCann's research output by year.

7Publications

Publications

2022

Heterogeneous nuclear ribonucleoprotein hnRNPA2/B1 regulates the abundance of the copper-transporter ATP7A in an isoform-dependent manner.
McCann CJ, Hasan NM, Padilla-Benavides T, Roy S, Lutsenko S. Heterogeneous nuclear ribonucleoprotein hnRNPA2/B1 regulates the abundance of the copper-transporter ATP7A in an isoform-dependent manner. Front Mol Biosci 2022, 9: 1067490. PMID: 36545508, DOI: 10.3389/fmolb.2022.1067490.
Peer-Reviewed Original Research
The mitochondrial Cu(+) transporter PiC2 (SLC25A3) is a target of MTF1 and contributes to the development of skeletal muscle in vitro.
McCann C, Quinteros M, Adelugba I, Morgada MN, Castelblanco AR, Davis EJ, Lanzirotti A, Hainer SJ, Vila AJ, Navea JG, Padilla-Benavides T. The mitochondrial Cu(+) transporter PiC2 (SLC25A3) is a target of MTF1 and contributes to the development of skeletal muscle in vitro. Front Mol Biosci 2022, 9: 1037941. PMID: 36438658, DOI: 10.3389/fmolb.2022.1037941.
Peer-Reviewed Original Research
ZIP11 Regulates Nuclear Zinc Homeostasis in HeLa Cells and Is Required for Proliferation and Establishment of the Carcinogenic Phenotype.
Olea-Flores M, Kan J, Carlson A, Syed SA, McCann C, Mondal V, Szady C, Ricker HM, McQueen A, Navea JG, Caromile LA, Padilla-Benavides T. ZIP11 Regulates Nuclear Zinc Homeostasis in HeLa Cells and Is Required for Proliferation and Establishment of the Carcinogenic Phenotype. Front Cell Dev Biol 2022, 10: 895433. PMID: 35898402, DOI: 10.3389/fcell.2022.895433.
Peer-Reviewed Original Research

2020

Analysis of Wilson disease mutations revealed that interactions between different ATP7B mutants modify their properties.
Roy S, McCann CJ, Ralle M, Ray K, Ray J, Lutsenko S, Jayakanthan S. Analysis of Wilson disease mutations revealed that interactions between different ATP7B mutants modify their properties. Sci Rep 2020, 10: 13487. PMID: 32778786, DOI: 10.1038/s41598-020-70366-7.
Peer-Reviewed Original Research

2019

Single nucleotide polymorphisms in the human ATP7B gene modify the properties of the ATP7B protein.
McCann CJ, Jayakanthan S, Siotto M, Yang N, Osipova M, Squitti R, Lutsenko S. Single nucleotide polymorphisms in the human ATP7B gene modify the properties of the ATP7B protein. Metallomics 2019, 11: 1128-1139. PMID: 31070637, DOI: 10.1039/c9mt00057g.
Peer-Reviewed Original Research
Chapter 4 - Biochemical and Cellular Properties of ATP7B Variants
Samuel Jayakanthan, Courtney McCann, Svetlana Lutsenko
Chapters

2013

The mechanism of Cu+ transport ATPases: interaction with CU+ chaperones and the role of transient metal-binding sites.
Padilla-Benavides T, McCann CJ, Argüello JM. The mechanism of Cu+ transport ATPases: interaction with CU+ chaperones and the role of transient metal-binding sites. J Biol Chem 2013, 288: 69-78. PMID: 23184962, DOI: 10.1074/jbc.M112.420810.
Peer-Reviewed Original Research

Get In Touch

Contacts

cat.mccann@yale.edu

Mailing Address

Pharmacology

333 Cedar St, SHM B 208B

New Haven, CT 06511

United States

Locations

Sterling Hall of Medicine
Academic Office
333 Cedar Street, Wing B, Fl 2, Rm 208
New Haven, CT 06510
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Events

Oct 20259Thursday

Yale Only
12:00 PM1:00 PM
Brent Stockwell, PhD
Yale Pharmacology Series
"Drugs, Food, and Metabolism: Ferroptosis as a New Therapeutic Paradigm"
Brady Memorial Laboratory
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Oct 202516Thursday

Yale Only
4:00 PM5:00 PM
Tobias Meyer, PhD
Yale Pharmacology presents the 2025 Alan C. Sartorelli Lecture: "Both Structural and Signaling Polarity Mechanisms Direct Cell Migration"
Pharmacology Seminar Series
The Anlyan Center
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Oct 202523Thursday

Yale Only
12:00 PM1:00 PM
Carl-Mikael Suomivuori
Yale Pharmacology presents: "Computation as a Virtual Microscope to Guide Drug Design"
Pharmacology Seminar Series
Brady Memorial Laboratory
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Oct 202530Thursday

Yale Only
12:00 PM1:00 PM
Lillian Chong, PhD
Yale Pharmacology presents: "Illuminating Hidden Protein States and Ligand Escape Pathways with Weighted Ensemble MD"
Pharmacology Seminar Series
Brady Memorial Laboratory
Add event to Calendar

See All Events

Contact Info

Education

Titles

Departments & Organizations

Education & Training

Research at a Glance

Publications Timeline

Publications

2022

Heterogeneous nuclear ribonucleoprotein hnRNPA2/B1 regulates the abundance of the copper-transporter ATP7A in an isoform-dependent manner.

The mitochondrial Cu(+) transporter PiC2 (SLC25A3) is a target of MTF1 and contributes to the development of skeletal muscle in vitro.

ZIP11 Regulates Nuclear Zinc Homeostasis in HeLa Cells and Is Required for Proliferation and Establishment of the Carcinogenic Phenotype.

2020

Analysis of Wilson disease mutations revealed that interactions between different ATP7B mutants modify their properties.

2019

Single nucleotide polymorphisms in the human ATP7B gene modify the properties of the ATP7B protein.

Chapter 4 - Biochemical and Cellular Properties of ATP7B Variants

2013

The mechanism of Cu+ transport ATPases: interaction with CU+ chaperones and the role of transient metal-binding sites.

Contacts

Locations

Sterling Hall of Medicine

Events

Yale Pharmacology Series

Yale Pharmacology presents the 2025 Alan C. Sartorelli Lecture: "Both Structural and Signaling Polarity Mechanisms Direct Cell Migration"

Yale Pharmacology presents: "Computation as a Virtual Microscope to Guide Drug Design"

Yale Pharmacology presents: "Illuminating Hidden Protein States and Ligand Escape Pathways with Weighted Ensemble MD"