Brian Wojeck, MD, MPH
Assistant Professor of Medicine (Endocrinology)Cards
About
Research
Publications
2025
The impact of obesity on upper airway anatomy as assessed by magnetic resonance imaging and obstructive sleep apnea endotypic traits.
Nokes B, Schueler A, Darquenne C, Schmickl CN, Wojeck BS, Moore S, Deyoung P, McGinnis L, Theilmann RJ, Gruenberg E, Grunvald E, Holloway BM, Alex RM, Sands S, Colvonen P, Owens RL, Malhotra A. The impact of obesity on upper airway anatomy as assessed by magnetic resonance imaging and obstructive sleep apnea endotypic traits. Front Physiol 2025, 16: 1648767. PMID: 41103297, DOI: 10.3389/fphys.2025.1648767.Peer-Reviewed Original ResearchAssociation Between Sleep-Related Leg Movements and Diabetes Prevalence: A Cohort Study From the United States
Ding Q, Xie Y, Koo B, Hass Z, Wojeck B, Sico J, Murray-Kolb L, Bravata D, Zinchuk A. Association Between Sleep-Related Leg Movements and Diabetes Prevalence: A Cohort Study From the United States. Cureus 2025, 17: e84701. PMID: 40557002, PMCID: PMC12185253, DOI: 10.7759/cureus.84701.Peer-Reviewed Original ResearchNational Health and Nutrition Examination SurveyShort sleep durationSleep durationDiabetes prevalenceHealth and Nutrition Examination SurveyNational population-based cohort studyNon-Hispanic white individualsCohort studyPopulation-based cohort studyWeighted logistic regression modelsOdds of diabetesNutrition Examination SurveyUS adult populationPrevalence of diabetesRisk of diabetesLeg movementsDiabetes mellitusLogistic regression modelsDM prevalenceExamination SurveyCardiometabolic healthUnited StatesWhite individualsAdult populationPotential mediators
2024
Understanding the impact of night-to-night sleep variations on glucose regulation in healthy young adults: Insights from Ng et al. (2024)
Ding Q, Wojeck B, Zinchuk A. Understanding the impact of night-to-night sleep variations on glucose regulation in healthy young adults: Insights from Ng et al. (2024). Sleep 2024, 48: zsae253. PMID: 39460669, PMCID: PMC11807883, DOI: 10.1093/sleep/zsae253.Peer-Reviewed Original ResearchEffect of obesity on sleep apnea pathogenesis differs in women versus men: multiple mediation analyses in the retrospective SNOOzzzE cohort
Nokes B, Orr J, White S, Luu S, Chen Z, Alex R, Sands S, Wojeck B, Owens R, Malhotra A, Schmickl C. Effect of obesity on sleep apnea pathogenesis differs in women versus men: multiple mediation analyses in the retrospective SNOOzzzE cohort. Journal Of Applied Physiology 2024, 136: 1516-1525. PMID: 38660729, PMCID: PMC11368527, DOI: 10.1152/japplphysiol.00925.2023.Peer-Reviewed Original ResearchApnea-hypopnea indexObstructive sleep apneaBody mass indexEffect of body mass indexCirculatory delayArousal thresholdAssociated with apnea-hypopnea indexObstructive sleep apnea risk factorsObstructive Sleep Apnea EndotypesIn-laboratory polysomnographyUpper airway collapseEvents per hourHigh arousal thresholdsEffect of obesityHypopnea indexOSA pathogenesisSleep apneaConsecutive adultsSleep clinicEndotypic traitsAirway collapseMass indexPathogenesis differencesRisk factorsPolysomnography signalsChapter 35 Diseases of the pituitary gland
Wojeck B, Kryger M. Chapter 35 Diseases of the pituitary gland. 2024, 374-378.e1. DOI: 10.1016/b978-0-323-65403-6.00044-5.Chapters
2023
Role of metformin in the management of type 2 diabetes: recent advances.
Gonzalez-Lopez C, Wojeck B. Role of metformin in the management of type 2 diabetes: recent advances. Polish Archives Of Internal Medicine 2023, 133 PMID: 37317976, DOI: 10.20452/pamw.16511.Peer-Reviewed Original ResearchConceptsType 2 diabetesAntidiabetic medicationsGlucagon-like peptide-1 receptor agonistsSodium-glucose cotransporter 2 inhibitorsPeptide-1 receptor agonistsCardio-renal protectionCotransporter 2 inhibitorsFirst-line agentsFirst-line therapyPolycystic ovary syndromeRole of metforminRisk of hypoglycemiaTreatment of obesityManagement of diabetesBlood glucose levelsMechanism of actionInitial therapyWay diabetesGestational diabetesOvary syndromeHeart failureRenal diseaseInsulin resistanceInsulin sensitivityReceptor agonistPolysomnographic predictors of incident diabetes and pre-diabetes: an analysis of the DREAM study.
Wojeck B, Inzucchi S, Qin L, Yaggi H. Polysomnographic predictors of incident diabetes and pre-diabetes: an analysis of the DREAM study. Journal Of Clinical Sleep Medicine 2023, 19: 703-710. PMID: 36689314, PMCID: PMC10071389, DOI: 10.5664/jcsm.10414.Peer-Reviewed Original ResearchConceptsApnea-hypopnea indexBody mass indexIncident diabetesPolysomnographic predictorsMass indexOxygen saturationMean nocturnal oxygen saturationObstructive sleep apnea (OSA) evaluationObstructive sleep apnea populationEpworth Sleepiness Scale scoreSleep apnea populationGlucose-lowering medicationsNocturnal oxygen saturationSleep-disordered breathingIncidence of diabetesPeriodic limb movementsLaboratory-based polysomnographyCheyne-Stokes respirationSleep apnea severitySleep apnea evaluationIncident prediabetesOxygen desaturationCentral apneaHemoglobin A1cPrimary outcome
2022
Ertugliflozin and incident obstructive sleep apnea: an analysis from the VERTIS CV trial
Wojeck BS, Inzucchi SE, Neeland IJ, Mancuso JP, Frederich R, Masiukiewicz U, Cater NB, McGuire DK, Cannon CP, Yaggi HK. Ertugliflozin and incident obstructive sleep apnea: an analysis from the VERTIS CV trial. Sleep And Breathing 2022, 27: 669-672. PMID: 35596030, PMCID: PMC10212814, DOI: 10.1007/s11325-022-02594-2.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaIncident obstructive sleep apneaAtherosclerotic CV diseaseVERTIS CVSleep apneaMultivariable Cox proportional hazards regression modelsIncidence of OSACox proportional hazards regression modelBaseline obstructive sleep apneaMajor adverse CV eventsProportional hazards regression modelsCV outcome trialsEffect of ertugliflozinInvestigator-reported eventsVERTIS-CV trialAdverse CV eventsSleep apnea syndromeRelative risk reductionHazards regression modelsType 2 diabetesCV eventsCV diseasePrimary endpointInhibitor empagliflozinOutcome trials
2021
Polysomnographic Phenotypes of Obstructive Sleep Apnea and Incident Type 2 Diabetes: Results from the DREAM Study.
Ding Q, Qin L, Wojeck B, Inzucchi SE, Ibrahim A, Bravata DM, Strohl KP, Yaggi HK, Zinchuk AV. Polysomnographic Phenotypes of Obstructive Sleep Apnea and Incident Type 2 Diabetes: Results from the DREAM Study. Annals Of The American Thoracic Society 2021, 18: 2067-2078. PMID: 34185617, PMCID: PMC8641817, DOI: 10.1513/annalsats.202012-1556oc.Peer-Reviewed Original ResearchConceptsApnea-hypopnea indexObstructive sleep apneaPolysomnographic phenotypeIncident T2DMRisk of T2DMPredictive valueSleep apneaBlood glucoseRisk factorsCardiovascular diseaseMild obstructive sleep apneaIncident type 2 diabetesMultivariable-adjusted regression modelsCox proportional hazards regressionNew physician diagnosisT2DM risk predictionIncident cardiovascular diseaseIncident type 2Body mass indexProportional hazards regressionT2DM risk factorsBehavioral risk factorsType 2 diabetesMale veteran populationRisk regression modelsLessons Learned From Major Clinical Outcomes Trials Involving Sodium-Glucose Cotransporter 2 Inhibitors.
Wojeck BS, Inzucchi SE. Lessons Learned From Major Clinical Outcomes Trials Involving Sodium-Glucose Cotransporter 2 Inhibitors. Diabetes Spectrum 2021, 34: 235-242. PMID: 34511849, PMCID: PMC8387615, DOI: 10.2337/ds20-0070.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsSodium-glucose cotransporter 2 inhibitorsCotransporter 2 inhibitorsMajor clinical outcome trialsRecent large clinical trialsDiabetes treatment guidelinesGlucose-lowering medicationsChronic kidney diseaseClinical outcome trialsLarge clinical trialsRenal outcomesOutcome trialsTreatment guidelinesKidney diseaseRisk factorsClinical trialsMedicationsTrialsInhibitorsDiabetesDisease
Clinical Care
Overview
Brian Wojeck, MD, MPH, is an assistant professor at Yale School of Medicine (YSM) in the Section of Endocrinology. He received his medical degree from University of Arizona and his master of public health from Emory University. He completed his internal medicine residency at Mayo Clinic and subspecialty fellowships in sleep medicine and endocrinology at YSM. He has additional training in obesity medicine and is a weight management specialist.
Dr. Wojeck's clinical and research focus is the comprehensive management of the interrelated disease processes of diabetes, obesity, and sleep disorders.
Clinical Specialties
Endocrinology; Sleep Medicine; Obesity Medicine
Fact Sheets
Sleep Study
Learn More on Yale MedicineSleep Apnea
Learn More on Yale MedicinePediatric Obstructive Sleep Apnea
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Board Certifications
Endocrinology Diabetes & Metabolism
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2022
Obesity Medicine
- Certification Organization
- AB of Obesity Medicine
- Original Certification Date
- 2020
Sleep Medicine (Internal Medicine)
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2017
Internal Medicine
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2016
Yale Medicine News
News
News
- October 07, 2025
Uncovering Hidden Risk Factors: Sleep-Related Leg Movements and Diabetes
- January 27, 2025
Drawing Connections Between Diabetes, Obesity, and Sleep
- October 18, 2022
Yale Endocrinology Obesity Medicine: Approaching Obesity as a Complex, Chronic Disease
- July 27, 2022
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