David Matuskey, MD

2026

• Widespread synaptic density loss in schizophrenia follows molecular and network architecture

  Chopra S, Worhunsky P, Naganawa M, Zhang X, Segal A, Labache L, Orchard E, Cropley V, Wood S, Angarita G, Cosgrove K, Matuskey D, Nabulsi N, Huang Y, Carson R, Esterlis I, Skosnik P, D’Souza D, Holmes A, Radhakrishnan R. Widespread synaptic density loss in schizophrenia follows molecular and network architecture. Molecular Psychiatry 2026, 1-12. PMID: 42350786, DOI: 10.1038/s41380-026-03717-x.

  Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements

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• Neuroimaging evidence for a dopamine-independent association between motor cortex microstructure and Parkinson’s disease severity

  Honhar P, Tinaz S, Ebrahimian Sadabad F, Dias M, Yang Y, Henry S, Hillmer A, Zakiniaeiz Y, Radhakrishnan R, Comley R, Zhang X, Hooker B, Zhang Y, Finnema S, Carson R, Scheinost D, Matuskey D. Neuroimaging evidence for a dopamine-independent association between motor cortex microstructure and Parkinson’s disease severity. Npj Parkinson's Disease 2026 PMID: 42248873, DOI: 10.1038/s41531-026-01411-x.

  Peer-Reviewed Original Research

• Impulsivity, reward sensitivity, and dopamine 2/3 receptors availability in people with cocaine use disorder: A [11C]PHNO PET study

  Mayeli M, Worhunsky P, Carson R, Potenza M, Angarita G, Matuskey D. Impulsivity, reward sensitivity, and dopamine 2/3 receptors availability in people with cocaine use disorder: A [11C]PHNO PET study. Psychiatry Research 2026, 364: 117239. PMID: 42229023, DOI: 10.1016/j.psychres.2026.117239.

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• Lower synaptic density in mood circuitry underlies depression in Parkinson’s disease

  Cayir S, Naganawa M, Volpi T, Sadabad F, Dias M, Yang Y, Elliott S, Ansari M, Elshahat A, Pittman B, Esterlis I, Nabulsi N, Huang Y, Sanacora G, Comley R, Finnema S, Carson R, Tinaz S, Matuskey D, Holmes S. Lower synaptic density in mood circuitry underlies depression in Parkinson’s disease. Brain Communications 2026, 8: fcag136. PMID: 42109687, PMCID: PMC13152014, DOI: 10.1093/braincomms/fcag136.

  Peer-Reviewed Original Research

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• Optimized reference region and the effect on test-retest reliability and sensitivity to differences between Parkinson’s disease and control groups with [11C]UCB-J

  Khattar N, Matuskey D, Gallezot J, Naganawa M, Holmes S, Sadabad F, Mayeli M, Esterlis I, van Dyck C, Mecca A, D’Souza D, Nabulsi N, Finnema S, Huang Y, Carson R, Toyonaga T. Optimized reference region and the effect on test-retest reliability and sensitivity to differences between Parkinson’s disease and control groups with [11C]UCB-J. Journal Of Cerebral Blood Flow And Metabolism : Official Journal Of The International Society Of Cerebral Blood Flow And Metabolism 2026, 0271678x261441071. PMID: 41960765, PMCID: PMC13068773, DOI: 10.1177/0271678x261441071.

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• Synaptic density imaging in behavioral variant frontotemporal dementia: A comparison of 18F‐SynVesT‐1 and 18F‐FDG PET

  Fesharaki‐Zadeh A, Cayir S, Ibrahim W, Yang Y, Gallezot J, Naganawa M, Wu Y, Toyonaga T, Sadabad F, O'Dell R, Pittman B, Nabulsi N, Strittmatter S, Carson R, Huang Y, van Dyck C, Mecca A, Matuskey D. Synaptic density imaging in behavioral variant frontotemporal dementia: A comparison of 18F‐SynVesT‐1 and 18F‐FDG PET. Alzheimer's & Dementia 2026, 22: e71283. PMID: 41954197, PMCID: PMC13063251, DOI: 10.1002/alz.71283.

  Peer-Reviewed Original Research

  This study investigates synaptic density imaging in behavioral variant frontotemporal dementia, showing that SV2A PET detects more pronounced synaptic loss than glucose hypometabolism using FDG PET, aiding early diagnosis and monitoring.

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• Variance reduction with synaptic density imaging in Parkinson’s disease using direct-4D PET image reconstruction

  Gravel P, Gallezot J, Fontaine K, Matuskey D, Carson R. Variance reduction with synaptic density imaging in Parkinson’s disease using direct-4D PET image reconstruction. Physics In Medicine And Biology 2026, 71: 065007. PMID: 41825140, PMCID: PMC13014069, DOI: 10.1088/1361-6560/ae520a.

  Peer-Reviewed Original Research

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  MeSH Keywords

• Dose Reduction in Dynamic PET Imaging Using Self-Supervised Two-Step Deep Image Prior

  Li A, Syed M, Naganawa M, Matuskey D, Carson R, Tang J. Dose Reduction in Dynamic PET Imaging Using Self-Supervised Two-Step Deep Image Prior. IEEE Transactions On Radiation And Plasma Medical Sciences 2026, PP: 1-1. DOI: 10.1109/trpms.2026.3671590.

  Peer-Reviewed Original Research

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• Dose reduction for synaptic density PET imaging in Parkinson’s disease

  Li A, Naganawa M, Honhar P, Fontaine K, Gravel P, Matuskey D, Carson R, Tang J. Dose reduction for synaptic density PET imaging in Parkinson’s disease. NeuroImage 2026, 331: 121853. PMID: 41833889, DOI: 10.1016/j.neuroimage.2026.121853.

  Peer-Reviewed Original Research

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• Social determinants of brain structure and cognition

  Mayeli M, Matuskey D, Initiative F. Social determinants of brain structure and cognition. Social Science & Medicine 2026, 394: 119045. PMID: 41662789, PMCID: PMC13034436, DOI: 10.1016/j.socscimed.2026.119045.

  Peer-Reviewed Original Research

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