Shakila A Taleb
Associate Research ScientistAbout
Research
Publications
2026
T cell receptors for antigen on intraepithelial cytolytic T lymphocytes in celiac disease engage enterocyte HLA-E and HLA-B
Johnson J, Agrawal K, Al-Lamki R, Zhang F, Wang X, Tobiasova Z, Taleb S, Liburd S, Rodriguez L, Martins A, Flavell R, Robert M, Sefik E, Pober J. T cell receptors for antigen on intraepithelial cytolytic T lymphocytes in celiac disease engage enterocyte HLA-E and HLA-B. Proceedings Of The National Academy Of Sciences Of The United States Of America 2026, 123: e2525433123. PMID: 41642982, PMCID: PMC12890992, DOI: 10.1073/pnas.2525433123.Peer-Reviewed Original ResearchConceptsCytotoxic T lymphocytesT cell receptorHLA-ET lymphocytesProximity ligation assayClass II HLA moleculesT cell receptor for antigenHLA-B mRNACytolytic T lymphocytesT cell subsetsCeliac diseaseReceptor for antigenActive celiac diseaseLigation assayCTL activityHLA-E.T cellsAntigen presentationFrequent bindingHLA moleculesDuodenal biopsiesHLA-BSingle-cell RNA sequencingNormal controlsHLA-B.
2024
Exploring Importance and Regulation of Autophagy in Cancer Stem Cells and Stem Cell-Based Therapies.
Rahman MA, Apu EH, Rakib-Uz-Zaman SM, Chakraborti S, Bhajan SK, Taleb SA, Shaikh MH, Jalouli M, Harrath AH, Kim B. Exploring Importance and Regulation of Autophagy in Cancer Stem Cells and Stem Cell-Based Therapies. Cells 2024, 13 PMID: 38891090, DOI: 10.3390/cells13110958.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsProminent role of gut dysbiosis in the pathogenesis of cystic fibrosis-related liver disease in mice
Bertolini A, Nguyen M, Zehra S, Taleb S, Bauer-Pisani T, Palm N, Strazzabosco M, Fiorotto R. Prominent role of gut dysbiosis in the pathogenesis of cystic fibrosis-related liver disease in mice. Journal Of Hepatology 2024, 81: 429-440. PMID: 38554847, PMCID: PMC11347101, DOI: 10.1016/j.jhep.2024.03.041.Peer-Reviewed Original ResearchCystic fibrosis-related liver diseaseCystic fibrosis transmembrane conductance regulatorCFTR-KO miceDefective cystic fibrosis transmembrane conductance regulatorCFTR-KOIntestinal permeabilityLiver diseaseGut-liver axisGut dysbiosisIncreased morbidityMortality of CF patientsAssociated with increased intestinal permeabilityLiver pathologyDevelopment of cholangiopathyCftr-knockout miceTransmembrane conductance regulatorIncreased intestinal permeabilityTargeted therapeutic strategiesFecal microbiota transferAttenuates liver diseaseExcessive inflammatory responseFITC-dextran assayPresence of neutrophilsActivation of pro-inflammatoryCFTR-knockout
2023
Cell-matrix interactions control biliary organoid polarity, architecture, and differentiation
Fiorotto R, Mariotti V, Taleb S, Zehra S, Nguyen M, Amenduni M, Strazzabosco M. Cell-matrix interactions control biliary organoid polarity, architecture, and differentiation. Hepatology Communications 2023, 7: e0094. PMID: 36972396, PMCID: PMC10503667, DOI: 10.1097/hc9.0000000000000094.Peer-Reviewed Original ResearchConceptsBiliary organoidsNovel organoid modelImmune cell typesOrganotypic culture systemProinflammatory chemokinesStem cell featuresBiliary epitheliumExtracellular matrixEpithelial permeabilityImportant causeBile acidsBiliary differentiationBile transportHuman liverOrganoid modelsDisease modelsCholangiopathyCell featuresTight junctionsLiverCell typesInternal lumenOrganoidsSingle-cell transcriptomicsPathogenic bacteria