Jyoti Gupta
Associate Research ScientistCards
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Research
Publications
2024
GABAergic Interneuron Dysfunction in Neurodevelopmental Disorders: A New Role for the Transcription Factor MEF2C in Regulating Parvalbumin Interneuron Survival and Function
Gupta J. GABAergic Interneuron Dysfunction in Neurodevelopmental Disorders: A New Role for the Transcription Factor MEF2C in Regulating Parvalbumin Interneuron Survival and Function. Biological Psychiatry 2024, 96: e19-e20. PMID: 39415396, DOI: 10.1016/j.biopsych.2024.09.001.Peer-Reviewed Original Research
2023
Masterminding Hippocampal Circuits by Transplanting Human GABAergic Interneurons to Treat Temporal Lobe Epilepsy
Gupta J, Naegele J. Masterminding Hippocampal Circuits by Transplanting Human GABAergic Interneurons to Treat Temporal Lobe Epilepsy. Epilepsy Currents 2023, 23: 268-270. PMID: 37662454, PMCID: PMC10470101, DOI: 10.1177/15357597231175010.Peer-Reviewed Original ResearchModel of epilepsyTemporal lobe epilepsyLong-term efficacySpecific synaptic connectionsAbort seizuresGraft functionMishra AHost neuronsSeizure controlLobe epilepsyIntractable epilepsySeizure activityGABAergic interneuronsMonosynaptic tracingCortical interneuronsHippocampal circuitsOptogenetic activationProlonged efficacyHost inhibitionSynaptic connectionsEpilepsySeizuresEfficacyInterneuronsClinical translationForming new connections: Advances in human stem-cell-derived interneuron therapy for treating epilepsy
Gupta J, Naegele J. Forming new connections: Advances in human stem-cell-derived interneuron therapy for treating epilepsy. Neuron 2023, 111: 758-760. PMID: 36924760, DOI: 10.1016/j.neuron.2023.02.034.Peer-Reviewed Original Research
2018
Pluripotent stem cell-derived interneuron progenitors mature and restore memory deficits but do not suppress seizures in the epileptic mouse brain
Anderson NC, Van Zandt MA, Shrestha S, Lawrence DB, Gupta J, Chen CY, Harrsch FA, Boyi T, Dundes CE, Aaron G, Naegele JR, Grabel L. Pluripotent stem cell-derived interneuron progenitors mature and restore memory deficits but do not suppress seizures in the epileptic mouse brain. Stem Cell Research 2018, 33: 83-94. PMID: 30340090, DOI: 10.1016/j.scr.2018.10.007.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyInterneuron progenitorsHippocampal-dependent spatial memory deficitsMemory deficitsMorris water maze testEpileptic mouse brainMature firing patternMature GABAergic interneuronsWater maze testSpatial memory deficitsGABAergic interneuron dysfunctionHippocampus of rodentsInterneuron dysfunctionLobe epilepsySuppress seizuresGABAergic interneuronsMaze testSeizure suppressionMouse modelMouse brainFiring patternsSeizuresTransplantMiceStem cells
2015
The Art of Setting Limits: Lessons from GABAergic Interneuron Transplantation
Gupta J, Naegele J. The Art of Setting Limits: Lessons from GABAergic Interneuron Transplantation. Epilepsy Currents 2015, 15: 347-348. PMID: 26633960, PMCID: PMC4657776, DOI: 10.5698/1535-7511-15.6.347.Peer-Reviewed Original Research
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