Alice Sherrard
Associate Research Scientist in GeneticsCards
About
Research
Publications
2024
A generalized nanogold tagging system for the identification of macromolecules in in situ tomograms
Young L, Sherrard A, Hutchings J, Villa E. A generalized nanogold tagging system for the identification of macromolecules in in situ tomograms. Biophysical Journal 2024, 123: 421a. DOI: 10.1016/j.bpj.2023.11.2561.Peer-Reviewed Original Research
2023
Chromatin expansion microscopy reveals nanoscale organization of transcription and chromatin
Pownall M, Miao L, Vejnar C, M'Saad O, Sherrard A, Frederick M, Benitez M, Boswell C, Zaret K, Bewersdorf J, Giraldez A. Chromatin expansion microscopy reveals nanoscale organization of transcription and chromatin. Science 2023, 381: 92-100. PMID: 37410825, PMCID: PMC10372697, DOI: 10.1126/science.ade5308.Peer-Reviewed Original ResearchConceptsZygotic genome activationTranscriptional elongationExpansion microscopyRNA polymerase IIChromatin regulatory factorsEnhancer-promoter contactsGenome activationChromatin organizationNuclear organizationPolymerase IIPol IIFactor NanogTranscription factorsGene expressionRegulatory factorsChromatinNanoscale organizationNanogTranscriptionElongationNucleosomesUniversal processPromoterEmbryosEnhancerCTLA4 depletes T cell endogenous and trogocytosed B7 ligands via cis-endocytosis
Xu X, Dennett P, Zhang J, Sherrard A, Zhao Y, Masubuchi T, Bui J, Chen X, Hui E. CTLA4 depletes T cell endogenous and trogocytosed B7 ligands via cis-endocytosis. Journal Of Experimental Medicine 2023, 220: e20221391. PMID: 37042938, PMCID: PMC10103642, DOI: 10.1084/jem.20221391.Peer-Reviewed Original ResearchConceptsT cellsMajor histocompatibility complexB7 ligandsHuman regulatory T cellsRegulatory T cellsSurface of T cellsCD28 costimulatory signalsAntigen-presenting-cellsAdaptive immune responsesHuman T cellsT cell coreceptorsCostimulatory signalsLigands CD80CTLA4Cell-intrinsicImmune responseCD28Histocompatibility complexTrogocytosisCD28:B7TregsCD80CD86Extrinsic functionsBlockadeVersatile nanogold tagging system applied to the identification of heterochromatin through cryo-FIB-ET
Young L, Sherrard A, Hutchings J, Giraldez A, Villa E. Versatile nanogold tagging system applied to the identification of heterochromatin through cryo-FIB-ET. Biophysical Journal 2023, 122: 316a. DOI: 10.1016/j.bpj.2022.11.1776.Peer-Reviewed Original Research