Curtis William Boswell, PhD
Associate Research Scientist in GeneticsAbout
Research
Publications
2025
In vivo differentiation of embryonic cells devoid of key reprogramming factors
Youlten S, Miao L, Hoppe C, Boswell C, Musaev D, Abdelmessih M, Olowookere D, Weiss L, Krishnaswamy S, Giraldez A, Tornini V. In vivo differentiation of embryonic cells devoid of key reprogramming factors. Cell Reports 2025, 44: 116498. PMID: 41171758, PMCID: PMC12841453, DOI: 10.1016/j.celrep.2025.116498.Peer-Reviewed Original ResearchGenetically encoded affinity reagents are a toolkit for visualizing and manipulating endogenous protein function in vivo
Boswell C, Hoppe C, Sherrard A, Miao L, Kojima M, Martino P, Zhao N, Stasevich T, Nicoli S, Giraldez A. Genetically encoded affinity reagents are a toolkit for visualizing and manipulating endogenous protein function in vivo. Nature Communications 2025, 16: 5503. PMID: 40595661, PMCID: PMC12216260, DOI: 10.1038/s41467-025-61003-w.Peer-Reviewed Original Research
2023
Apollo-NADP+ reveals in vivo adaptation of NADPH/NADP+ metabolism in electrically activated pancreatic β cells
Bui C, Boswell C, Ciruna B, Rocheleau J. Apollo-NADP+ reveals in vivo adaptation of NADPH/NADP+ metabolism in electrically activated pancreatic β cells. Science Advances 2023, 9: eadi8317. PMID: 37792934, PMCID: PMC10550227, DOI: 10.1126/sciadv.adi8317.Peer-Reviewed Original ResearchChromatin expansion microscopy reveals nanoscale organization of transcription and chromatin
Pownall M, Miao L, Vejnar C, M'Saad O, Sherrard A, Frederick M, Benitez M, Boswell C, Zaret K, Bewersdorf J, Giraldez A. Chromatin expansion microscopy reveals nanoscale organization of transcription and chromatin. Science 2023, 381: 92-100. PMID: 37410825, PMCID: PMC10372697, DOI: 10.1126/science.ade5308.Peer-Reviewed Original Research
2022
Live imaging and conditional disruption of native PCP activity using endogenously tagged zebrafish sfGFP-Vangl2
Jussila M, Boswell C, Griffiths N, Pumputis P, Ciruna B. Live imaging and conditional disruption of native PCP activity using endogenously tagged zebrafish sfGFP-Vangl2. Nature Communications 2022, 13: 5598. PMID: 36151137, PMCID: PMC9508082, DOI: 10.1038/s41467-022-33322-9.Peer-Reviewed Original Research
2020
The NEMP family supports metazoan fertility and nuclear envelope stiffness
Tsatskis Y, Rosenfeld R, Pearson J, Boswell C, Qu Y, Kim K, Fabian L, Mohammad A, Wang X, Robson M, Krchma K, Wu J, Gonçalves J, Hodzic D, Wu S, Potter D, Pelletier L, Dunham W, Gingras A, Sun Y, Meng J, Godt D, Schedl T, Ciruna B, Choi K, Perry J, Bremner R, Schirmer E, Brill J, Jurisicova A, McNeill H. The NEMP family supports metazoan fertility and nuclear envelope stiffness. Science Advances 2020, 6: eabb4591. PMID: 32923640, PMCID: PMC7455189, DOI: 10.1126/sciadv.abb4591.Peer-Reviewed Original Research
2018
Neuroinflammatory signals drive spinal curve formation in zebrafish models of idiopathic scoliosis
Van Gennip JLM, Boswell CW, Ciruna B. Neuroinflammatory signals drive spinal curve formation in zebrafish models of idiopathic scoliosis. Science Advances 2018, 4: eaav1781. PMID: 30547092, PMCID: PMC6291318, DOI: 10.1126/sciadv.aav1781.Peer-Reviewed Original ResearchMutations in Kinesin family member 6 reveal specific role in ependymal cell ciliogenesis and human neurological development
Konjikusic MJ, Yeetong P, Boswell CW, Lee C, Roberson EC, Ittiwut R, Suphapeetiporn K, Ciruna B, Gurnett CA, Wallingford JB, Shotelersuk V, Gray RS. Mutations in Kinesin family member 6 reveal specific role in ependymal cell ciliogenesis and human neurological development. PLOS Genetics 2018, 14: e1007817. PMID: 30475797, PMCID: PMC6307780, DOI: 10.1371/journal.pgen.1007817.Peer-Reviewed Original ResearchAmino Acid SequenceAnimalsAnimals, Genetically ModifiedBase SequenceChildCiliaConsanguinityEpendymaFemaleGene ExpressionHomozygoteHumansHydrocephalusIntellectual DisabilityKinesinsMaleMiceMice, TransgenicModels, AnimalMutationNeurodevelopmental DisordersPedigreeSequence DeletionTissue DistributionXenopus laevisZebrafish
2017
Understanding Idiopathic Scoliosis: A New Zebrafish School of Thought
Boswell CW, Ciruna B. Understanding Idiopathic Scoliosis: A New Zebrafish School of Thought. Trends In Genetics 2017, 33: 183-196. PMID: 28174019, DOI: 10.1016/j.tig.2017.01.001.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2016
Zebrafish models of idiopathic scoliosis link cerebrospinal fluid flow defects to spine curvature
Grimes DT, Boswell CW, Morante NF, Henkelman RM, Burdine RD, Ciruna B. Zebrafish models of idiopathic scoliosis link cerebrospinal fluid flow defects to spine curvature. Science 2016, 352: 1341-1344. PMID: 27284198, PMCID: PMC5574193, DOI: 10.1126/science.aaf6419.Peer-Reviewed Original Research